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Gene: ISG20 |
Gene summary for ISG20 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ISG20 | Gene ID | 3669 |
| Gene name | interferon stimulated exonuclease gene 20 | |
| Gene Alias | CD25 | |
| Cytomap | 15q26.1 | |
| Gene Type | protein-coding | GO ID | GO:0000738 | UniProtAcc | Q96AZ6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3669 | ISG20 | P84T-E | Human | Esophagus | ESCC | 5.97e-05 | 1.21e+00 | 0.0933 |
| 3669 | ISG20 | P89T-E | Human | Esophagus | ESCC | 6.87e-13 | 1.54e+00 | 0.1752 |
| 3669 | ISG20 | P91T-E | Human | Esophagus | ESCC | 4.35e-14 | 2.35e+00 | 0.1828 |
| 3669 | ISG20 | P94T-E | Human | Esophagus | ESCC | 5.63e-07 | 1.40e+00 | 0.0879 |
| 3669 | ISG20 | P104T-E | Human | Esophagus | ESCC | 1.12e-03 | 6.67e-01 | 0.0931 |
| 3669 | ISG20 | P107T-E | Human | Esophagus | ESCC | 4.22e-18 | 1.54e+00 | 0.171 |
| 3669 | ISG20 | P126T-E | Human | Esophagus | ESCC | 6.23e-03 | 1.45e+00 | 0.1125 |
| 3669 | ISG20 | P127T-E | Human | Esophagus | ESCC | 2.73e-07 | 4.01e-01 | 0.0826 |
| 3669 | ISG20 | P128T-E | Human | Esophagus | ESCC | 8.05e-57 | 3.03e+00 | 0.1241 |
| 3669 | ISG20 | P130T-E | Human | Esophagus | ESCC | 1.31e-22 | 1.32e+00 | 0.1676 |
| 3669 | ISG20 | S43 | Human | Liver | Cirrhotic | 1.37e-03 | -2.33e-01 | -0.0187 |
| 3669 | ISG20 | HCC1_Meng | Human | Liver | HCC | 1.67e-74 | 7.21e-02 | 0.0246 |
| 3669 | ISG20 | HCC2_Meng | Human | Liver | HCC | 6.45e-40 | 2.33e-01 | 0.0107 |
| 3669 | ISG20 | cirrhotic1 | Human | Liver | Cirrhotic | 5.76e-06 | 5.56e-02 | 0.0202 |
| 3669 | ISG20 | cirrhotic2 | Human | Liver | Cirrhotic | 1.27e-11 | 8.88e-02 | 0.0201 |
| 3669 | ISG20 | cirrhotic3 | Human | Liver | Cirrhotic | 9.57e-04 | -3.86e-02 | 0.0215 |
| 3669 | ISG20 | Pt13.b | Human | Liver | HCC | 5.24e-14 | 1.51e-01 | 0.0251 |
| 3669 | ISG20 | S027 | Human | Liver | HCC | 1.14e-12 | 2.41e+00 | 0.2446 |
| 3669 | ISG20 | S028 | Human | Liver | HCC | 2.54e-21 | 2.07e+00 | 0.2503 |
| 3669 | ISG20 | S029 | Human | Liver | HCC | 5.55e-26 | 3.35e+00 | 0.2581 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
| GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
| GO:00064019 | Cervix | CC | RNA catabolic process | 62/2311 | 278/18723 | 2.18e-06 | 6.56e-05 | 62 |
| GO:001907910 | Cervix | CC | viral genome replication | 35/2311 | 131/18723 | 6.11e-06 | 1.49e-04 | 35 |
| GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
| GO:00096158 | Cervix | CC | response to virus | 73/2311 | 367/18723 | 2.22e-05 | 3.95e-04 | 73 |
| GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
| GO:005079210 | Cervix | CC | regulation of viral process | 38/2311 | 164/18723 | 8.12e-05 | 1.10e-03 | 38 |
| GO:00467008 | Cervix | CC | heterocycle catabolic process | 80/2311 | 445/18723 | 3.23e-04 | 3.42e-03 | 80 |
| GO:00346559 | Cervix | CC | nucleobase-containing compound catabolic process | 74/2311 | 407/18723 | 3.77e-04 | 3.88e-03 | 74 |
| GO:190390010 | Cervix | CC | regulation of viral life cycle | 33/2311 | 148/18723 | 4.86e-04 | 4.76e-03 | 33 |
| GO:00485256 | Cervix | CC | negative regulation of viral process | 23/2311 | 92/18723 | 6.39e-04 | 5.97e-03 | 23 |
| GO:00442709 | Cervix | CC | cellular nitrogen compound catabolic process | 79/2311 | 451/18723 | 7.80e-04 | 6.91e-03 | 79 |
| GO:00450698 | Cervix | CC | regulation of viral genome replication | 21/2311 | 85/18723 | 1.27e-03 | 1.01e-02 | 21 |
| GO:00194398 | Cervix | CC | aromatic compound catabolic process | 79/2311 | 467/18723 | 2.14e-03 | 1.54e-02 | 79 |
| GO:00450714 | Cervix | CC | negative regulation of viral genome replication | 15/2311 | 56/18723 | 2.60e-03 | 1.80e-02 | 15 |
| GO:19013618 | Cervix | CC | organic cyclic compound catabolic process | 80/2311 | 495/18723 | 6.77e-03 | 3.72e-02 | 80 |
| GO:00160727 | Cervix | CC | rRNA metabolic process | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
| GO:00516072 | Cervix | CC | defense response to virus | 46/2311 | 265/18723 | 1.04e-02 | 4.97e-02 | 46 |
| GO:01405462 | Cervix | CC | defense response to symbiont | 46/2311 | 265/18723 | 1.04e-02 | 4.97e-02 | 46 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ISG20 | SNV | Missense_Mutation | rs371941091 | c.182N>A | p.Pro61His | p.P61H | Q96AZ6 | protein_coding | tolerated(0.08) | benign(0.222) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | novel | c.439N>T | p.Leu147Phe | p.L147F | Q96AZ6 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | rs549880749 | c.353N>A | p.Arg118His | p.R118H | Q96AZ6 | protein_coding | tolerated(0.2) | benign(0.006) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR |
| ISG20 | SNV | Missense_Mutation | rs149381576 | c.380G>A | p.Arg127His | p.R127H | Q96AZ6 | protein_coding | tolerated(0.14) | benign(0.148) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | c.209N>G | p.Phe70Cys | p.F70C | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ISG20 | SNV | Missense_Mutation | c.325N>A | p.Asp109Asn | p.D109N | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ISG20 | SNV | Missense_Mutation | rs772920253 | c.329C>T | p.Thr110Met | p.T110M | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| ISG20 | SNV | Missense_Mutation | novel | c.464N>T | p.Ala155Val | p.A155V | Q96AZ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | rs760289978 | c.406N>T | p.Arg136Cys | p.R136C | Q96AZ6 | protein_coding | deleterious(0.01) | possibly_damaging(0.882) | TCGA-EY-A549-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ISG20 | SNV | Missense_Mutation | novel | c.378N>C | p.Arg126Ser | p.R126S | Q96AZ6 | protein_coding | tolerated(0.52) | benign(0.014) | TCGA-69-8254-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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