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Gene: IMPA1 |
Gene summary for IMPA1 |
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Gene information | Species | Human | Gene symbol | IMPA1 | Gene ID | 3612 |
Gene name | inositol monophosphatase 1 | |
Gene Alias | IMP | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | A0A140VJL8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3612 | IMPA1 | NAFLD1 | Human | Liver | NAFLD | 6.52e-04 | 5.37e-01 | -0.04 |
3612 | IMPA1 | S43 | Human | Liver | Cirrhotic | 3.17e-04 | -7.66e-02 | -0.0187 |
3612 | IMPA1 | HCC1_Meng | Human | Liver | HCC | 4.13e-71 | 2.02e-01 | 0.0246 |
3612 | IMPA1 | HCC2_Meng | Human | Liver | HCC | 1.78e-19 | 9.37e-02 | 0.0107 |
3612 | IMPA1 | HCC1 | Human | Liver | HCC | 2.59e-08 | 4.02e+00 | 0.5336 |
3612 | IMPA1 | HCC2 | Human | Liver | HCC | 1.17e-19 | 4.10e+00 | 0.5341 |
3612 | IMPA1 | Pt13.b | Human | Liver | HCC | 1.87e-04 | 1.41e-01 | 0.0251 |
3612 | IMPA1 | S014 | Human | Liver | HCC | 3.88e-25 | 9.52e-01 | 0.2254 |
3612 | IMPA1 | S015 | Human | Liver | HCC | 1.61e-29 | 1.29e+00 | 0.2375 |
3612 | IMPA1 | S016 | Human | Liver | HCC | 5.38e-38 | 1.13e+00 | 0.2243 |
3612 | IMPA1 | S027 | Human | Liver | HCC | 2.09e-06 | 7.62e-01 | 0.2446 |
3612 | IMPA1 | S028 | Human | Liver | HCC | 1.02e-16 | 8.29e-01 | 0.2503 |
3612 | IMPA1 | S029 | Human | Liver | HCC | 3.09e-24 | 1.24e+00 | 0.2581 |
3612 | IMPA1 | C04 | Human | Oral cavity | OSCC | 4.90e-08 | 4.68e-01 | 0.2633 |
3612 | IMPA1 | C21 | Human | Oral cavity | OSCC | 1.11e-21 | 7.26e-01 | 0.2678 |
3612 | IMPA1 | C30 | Human | Oral cavity | OSCC | 5.33e-14 | 8.33e-01 | 0.3055 |
3612 | IMPA1 | C43 | Human | Oral cavity | OSCC | 2.00e-07 | 2.85e-01 | 0.1704 |
3612 | IMPA1 | C46 | Human | Oral cavity | OSCC | 5.31e-05 | 1.36e-01 | 0.1673 |
3612 | IMPA1 | C51 | Human | Oral cavity | OSCC | 2.54e-08 | 4.84e-01 | 0.2674 |
3612 | IMPA1 | C57 | Human | Oral cavity | OSCC | 1.98e-04 | 1.80e-01 | 0.1679 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00442626 | Esophagus | ESCC | cellular carbohydrate metabolic process | 160/8552 | 283/18723 | 1.43e-04 | 9.66e-04 | 160 |
GO:00160514 | Esophagus | ESCC | carbohydrate biosynthetic process | 117/8552 | 202/18723 | 2.96e-04 | 1.79e-03 | 117 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
GO:00442827 | Esophagus | ESCC | small molecule catabolic process | 201/8552 | 376/18723 | 1.35e-03 | 6.41e-03 | 201 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:00346372 | Esophagus | ESCC | cellular carbohydrate biosynthetic process | 46/8552 | 78/18723 | 1.24e-02 | 4.13e-02 | 46 |
GO:00066611 | Esophagus | ESCC | phosphatidylinositol biosynthetic process | 73/8552 | 131/18723 | 1.31e-02 | 4.28e-02 | 73 |
GO:00442825 | Liver | NAFLD | small molecule catabolic process | 91/1882 | 376/18723 | 8.96e-16 | 1.31e-12 | 91 |
GO:00442623 | Liver | NAFLD | cellular carbohydrate metabolic process | 55/1882 | 283/18723 | 1.27e-06 | 6.01e-05 | 55 |
GO:0016051 | Liver | NAFLD | carbohydrate biosynthetic process | 43/1882 | 202/18723 | 1.55e-06 | 6.96e-05 | 43 |
GO:00060666 | Liver | NAFLD | alcohol metabolic process | 62/1882 | 353/18723 | 9.01e-06 | 2.96e-04 | 62 |
GO:00464863 | Liver | NAFLD | glycerolipid metabolic process | 66/1882 | 392/18723 | 1.94e-05 | 5.52e-04 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IMPA1 | SNV | Missense_Mutation | c.122N>C | p.Ser41Thr | p.S41T | P29218 | protein_coding | tolerated_low_confidence(0.42) | benign(0.001) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
IMPA1 | SNV | Missense_Mutation | c.116N>C | p.Gly39Ala | p.G39A | P29218 | protein_coding | deleterious_low_confidence(0.04) | benign(0.081) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IMPA1 | deletion | Frame_Shift_Del | c.970delG | p.Glu324LysfsTer15 | p.E324Kfs*15 | P29218 | protein_coding | TCGA-A7-A4SA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |||
IMPA1 | deletion | In_Frame_Del | novel | c.746_748delNNN | p.Ile249del | p.I249del | P29218 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IMPA1 | SNV | Missense_Mutation | novel | c.788C>G | p.Ala263Gly | p.A263G | P29218 | protein_coding | deleterious(0) | probably_damaging(0.914) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
IMPA1 | SNV | Missense_Mutation | c.959N>T | p.Arg320Met | p.R320M | P29218 | protein_coding | tolerated(0.06) | benign(0.061) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
IMPA1 | SNV | Missense_Mutation | c.703N>A | p.Leu235Ile | p.L235I | P29218 | protein_coding | tolerated(0.13) | benign(0.184) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IMPA1 | SNV | Missense_Mutation | novel | c.689N>A | p.Thr230Asn | p.T230N | P29218 | protein_coding | tolerated(0.16) | benign(0.011) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IMPA1 | SNV | Missense_Mutation | novel | c.259N>C | p.Lys87Gln | p.K87Q | P29218 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IMPA1 | SNV | Missense_Mutation | rs767783535 | c.1000G>A | p.Asp334Asn | p.D334N | P29218 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3612 | IMPA1 | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL2103738 | LITHIUM CITRATE | |
3612 | IMPA1 | ENZYME, DRUGGABLE GENOME | inhibitor | 178101897 | ||
3612 | IMPA1 | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL1200826 | LITHIUM CARBONATE |
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