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Gene: IFITM3 |
Gene summary for IFITM3 |
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Gene information | Species | Human | Gene symbol | IFITM3 | Gene ID | 10410 |
Gene name | interferon induced transmembrane protein 3 | |
Gene Alias | 1-8U | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q01628 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10410 | IFITM3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.40e-08 | 5.92e-01 | -0.0179 |
10410 | IFITM3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.92e-82 | 2.00e+00 | 0.096 |
10410 | IFITM3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.80e-11 | 1.02e+00 | 0.0446 |
10410 | IFITM3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.66e-04 | 6.45e-01 | 0.0451 |
10410 | IFITM3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.01e-04 | 5.60e-01 | 0.0528 |
10410 | IFITM3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.55e-17 | 1.16e+00 | 0.0131 |
10410 | IFITM3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.93e-07 | 4.83e-01 | -0.0177 |
10410 | IFITM3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.34e-06 | 8.56e-01 | 0.0171 |
10410 | IFITM3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.40e-16 | 7.54e-01 | 0.0338 |
10410 | IFITM3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.08e-64 | 1.29e+00 | 0.0674 |
10410 | IFITM3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 6.41e-12 | 6.79e-01 | 0.0112 |
10410 | IFITM3 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.67e-05 | 8.97e-01 | -0.0124 |
10410 | IFITM3 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.10e-17 | 1.40e+00 | 0.0397 |
10410 | IFITM3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.32e-20 | 9.23e-01 | 0.0588 |
10410 | IFITM3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.98e-104 | 2.86e+00 | 0.294 |
10410 | IFITM3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 6.22e-15 | 2.98e+00 | 0.3487 |
10410 | IFITM3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.57e-55 | 2.30e+00 | 0.281 |
10410 | IFITM3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.47e-79 | 2.01e+00 | 0.3859 |
10410 | IFITM3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.27e-66 | 3.27e+00 | 0.2585 |
10410 | IFITM3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.61e-100 | 2.01e+00 | 0.3005 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160329 | Breast | Precancer | viral process | 58/1080 | 415/18723 | 3.42e-10 | 3.16e-08 | 58 |
GO:00190589 | Breast | Precancer | viral life cycle | 47/1080 | 317/18723 | 2.42e-09 | 1.99e-07 | 47 |
GO:00444039 | Breast | Precancer | biological process involved in symbiotic interaction | 42/1080 | 290/18723 | 3.40e-08 | 2.11e-06 | 42 |
GO:00521269 | Breast | Precancer | movement in host environment | 29/1080 | 175/18723 | 2.59e-07 | 1.28e-05 | 29 |
GO:00517019 | Breast | Precancer | biological process involved in interaction with host | 31/1080 | 203/18723 | 6.52e-07 | 2.71e-05 | 31 |
GO:00507929 | Breast | Precancer | regulation of viral process | 27/1080 | 164/18723 | 7.59e-07 | 3.05e-05 | 27 |
GO:00444099 | Breast | Precancer | entry into host | 25/1080 | 151/18723 | 1.74e-06 | 6.19e-05 | 25 |
GO:00467189 | Breast | Precancer | viral entry into host cell | 24/1080 | 144/18723 | 2.46e-06 | 8.35e-05 | 24 |
GO:00190799 | Breast | Precancer | viral genome replication | 22/1080 | 131/18723 | 5.63e-06 | 1.66e-04 | 22 |
GO:00439039 | Breast | Precancer | regulation of biological process involved in symbiotic interaction | 15/1080 | 72/18723 | 1.23e-05 | 3.17e-04 | 15 |
GO:19039009 | Breast | Precancer | regulation of viral life cycle | 23/1080 | 148/18723 | 1.31e-05 | 3.30e-04 | 23 |
GO:00523727 | Breast | Precancer | modulation by symbiont of entry into host | 12/1080 | 49/18723 | 1.61e-05 | 3.93e-04 | 12 |
GO:00465964 | Breast | Precancer | regulation of viral entry into host cell | 11/1080 | 42/18723 | 1.83e-05 | 4.35e-04 | 11 |
GO:19039014 | Breast | Precancer | negative regulation of viral life cycle | 7/1080 | 25/18723 | 4.00e-04 | 5.42e-03 | 7 |
GO:0046597 | Breast | Precancer | negative regulation of viral entry into host cell | 6/1080 | 21/18723 | 9.31e-04 | 1.06e-02 | 6 |
GO:00450697 | Breast | Precancer | regulation of viral genome replication | 13/1080 | 85/18723 | 1.12e-03 | 1.23e-02 | 13 |
GO:00485255 | Breast | Precancer | negative regulation of viral process | 12/1080 | 92/18723 | 6.51e-03 | 4.51e-02 | 12 |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:001907914 | Breast | IDC | viral genome replication | 32/1434 | 131/18723 | 2.82e-09 | 2.46e-07 | 32 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFITM3 | SNV | Missense_Mutation | c.24N>A | p.Phe8Leu | p.F8L | Q01628 | protein_coding | tolerated(0.1) | benign(0.053) | TCGA-E2-A154-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
IFITM3 | SNV | Missense_Mutation | c.349N>T | p.Met117Leu | p.M117L | Q01628 | protein_coding | tolerated(0.99) | benign(0) | TCGA-E9-A1N5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
IFITM3 | SNV | Missense_Mutation | c.151N>C | p.Glu51Gln | p.E51Q | Q01628 | protein_coding | deleterious(0.02) | possibly_damaging(0.511) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
IFITM3 | SNV | Missense_Mutation | novel | c.212N>A | p.Cys71Tyr | p.C71Y | Q01628 | protein_coding | deleterious(0.01) | benign(0.091) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFITM3 | SNV | Missense_Mutation | c.94C>A | p.Leu32Met | p.L32M | Q01628 | protein_coding | tolerated(0.11) | possibly_damaging(0.542) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
IFITM3 | SNV | Missense_Mutation | c.245T>C | p.Val82Ala | p.V82A | Q01628 | protein_coding | deleterious(0.01) | possibly_damaging(0.519) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IFITM3 | insertion | Frame_Shift_Ins | novel | c.122_123insC | p.Thr42AspfsTer44 | p.T42Dfs*44 | Q01628 | protein_coding | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IFITM3 | SNV | Missense_Mutation | novel | c.5N>G | p.Asn2Ser | p.N2S | Q01628 | protein_coding | tolerated(0.33) | benign(0.018) | TCGA-CN-A498-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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