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Gene: ICAM3 |
Gene summary for ICAM3 |
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Gene information | Species | Human | Gene symbol | ICAM3 | Gene ID | 3385 |
Gene name | intercellular adhesion molecule 3 | |
Gene Alias | CD50 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | K7ERN2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3385 | ICAM3 | PTC05 | Human | Thyroid | PTC | 5.37e-07 | 1.60e-01 | 0.2065 |
3385 | ICAM3 | PTC06 | Human | Thyroid | PTC | 4.96e-06 | 2.29e-01 | 0.2057 |
3385 | ICAM3 | PTC07 | Human | Thyroid | PTC | 5.54e-17 | 2.09e-01 | 0.2044 |
3385 | ICAM3 | ATC12 | Human | Thyroid | ATC | 9.07e-10 | 2.44e-01 | 0.34 |
3385 | ICAM3 | ATC13 | Human | Thyroid | ATC | 5.54e-06 | 1.68e-01 | 0.34 |
3385 | ICAM3 | ATC2 | Human | Thyroid | ATC | 1.62e-10 | 9.75e-01 | 0.34 |
3385 | ICAM3 | ATC4 | Human | Thyroid | ATC | 9.73e-15 | 3.77e-01 | 0.34 |
3385 | ICAM3 | ATC5 | Human | Thyroid | ATC | 3.11e-15 | 1.87e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ICAM3 | SNV | Missense_Mutation | c.749C>T | p.Ser250Leu | p.S250L | P32942 | protein_coding | tolerated(0.1) | benign(0.19) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
ICAM3 | SNV | Missense_Mutation | c.162T>A | p.Ser54Arg | p.S54R | P32942 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
ICAM3 | SNV | Missense_Mutation | novel | c.619A>C | p.Thr207Pro | p.T207P | P32942 | protein_coding | deleterious(0.04) | possibly_damaging(0.719) | TCGA-D8-A27F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
ICAM3 | SNV | Missense_Mutation | novel | c.599G>A | p.Gly200Glu | p.G200E | P32942 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ICAM3 | SNV | Missense_Mutation | c.352N>A | p.Glu118Lys | p.E118K | P32942 | protein_coding | tolerated(0.08) | possibly_damaging(0.602) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ICAM3 | SNV | Missense_Mutation | c.1204N>C | p.Ile402Leu | p.I402L | P32942 | protein_coding | tolerated(0.83) | benign(0.03) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ICAM3 | SNV | Missense_Mutation | c.1363A>C | p.Thr455Pro | p.T455P | P32942 | protein_coding | tolerated(0.14) | benign(0.425) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ICAM3 | SNV | Missense_Mutation | c.1189N>A | p.Leu397Met | p.L397M | P32942 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ICAM3 | SNV | Missense_Mutation | rs768855498 | c.871N>A | p.Glu291Lys | p.E291K | P32942 | protein_coding | tolerated(0.26) | benign(0.031) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ICAM3 | SNV | Missense_Mutation | c.844G>A | p.Ala282Thr | p.A282T | P32942 | protein_coding | tolerated(0.05) | possibly_damaging(0.579) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3385 | ICAM3 | DRUGGABLE GENOME | CSA | CYCLOSPORINE | 15732868 | |
3385 | ICAM3 | DRUGGABLE GENOME | INTERFERONS | 14989786 | ||
3385 | ICAM3 | DRUGGABLE GENOME | VITAMIN D | 10891379 | ||
3385 | ICAM3 | DRUGGABLE GENOME | inhibitor | CHEMBL2109481 | ICM3 | |
3385 | ICAM3 | DRUGGABLE GENOME | GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR | 12600815 | ||
3385 | ICAM3 | DRUGGABLE GENOME | PMA | 7525295 | ||
3385 | ICAM3 | DRUGGABLE GENOME | GM-CSF | REGRAMOSTIM | 12600815 | |
3385 | ICAM3 | DRUGGABLE GENOME | METHOTREXATE | METHOTREXATE | 16215763 |
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