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Gene: HIST1H2BC |
Gene summary for HIST1H2BC |
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Gene information | Species | Human | Gene symbol | HIST1H2BC | Gene ID | 8347 |
Gene name | H2B clustered histone 4 | |
Gene Alias | H2B.1 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0002227 | UniProtAcc | B2R4S9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8347 | HIST1H2BC | P107T-E | Human | Esophagus | ESCC | 2.14e-15 | 6.97e-01 | 0.171 |
8347 | HIST1H2BC | P126T-E | Human | Esophagus | ESCC | 3.80e-16 | 1.34e+00 | 0.1125 |
8347 | HIST1H2BC | P127T-E | Human | Esophagus | ESCC | 2.35e-87 | 1.82e+00 | 0.0826 |
8347 | HIST1H2BC | P128T-E | Human | Esophagus | ESCC | 1.47e-05 | 3.61e-01 | 0.1241 |
8347 | HIST1H2BC | P130T-E | Human | Esophagus | ESCC | 4.07e-44 | 1.19e+00 | 0.1676 |
8347 | HIST1H2BC | HCC1_Meng | Human | Liver | HCC | 1.54e-56 | 2.42e-01 | 0.0246 |
8347 | HIST1H2BC | Pt13.a | Human | Liver | HCC | 4.93e-06 | 1.53e-01 | 0.021 |
8347 | HIST1H2BC | Pt13.b | Human | Liver | HCC | 4.52e-15 | 2.45e-01 | 0.0251 |
8347 | HIST1H2BC | S014 | Human | Liver | HCC | 2.83e-27 | 9.42e-01 | 0.2254 |
8347 | HIST1H2BC | S015 | Human | Liver | HCC | 6.77e-12 | 4.92e-01 | 0.2375 |
8347 | HIST1H2BC | S016 | Human | Liver | HCC | 6.13e-33 | 8.97e-01 | 0.2243 |
8347 | HIST1H2BC | S027 | Human | Liver | HCC | 1.88e-10 | 6.19e-01 | 0.2446 |
8347 | HIST1H2BC | S028 | Human | Liver | HCC | 7.67e-31 | 1.27e+00 | 0.2503 |
8347 | HIST1H2BC | S029 | Human | Liver | HCC | 4.67e-39 | 1.80e+00 | 0.2581 |
8347 | HIST1H2BC | C04 | Human | Oral cavity | OSCC | 7.16e-18 | 8.25e-01 | 0.2633 |
8347 | HIST1H2BC | C21 | Human | Oral cavity | OSCC | 5.37e-20 | 6.58e-01 | 0.2678 |
8347 | HIST1H2BC | C30 | Human | Oral cavity | OSCC | 3.14e-40 | 2.06e+00 | 0.3055 |
8347 | HIST1H2BC | C38 | Human | Oral cavity | OSCC | 2.38e-04 | 3.01e-01 | 0.172 |
8347 | HIST1H2BC | C51 | Human | Oral cavity | OSCC | 1.79e-02 | 1.94e-01 | 0.2674 |
8347 | HIST1H2BC | C06 | Human | Oral cavity | OSCC | 5.31e-08 | 6.59e-01 | 0.2699 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2BC | SNV | Missense_Mutation | c.214G>C | p.Glu72Gln | p.E72Q | P62807 | protein_coding | deleterious_low_confidence(0.02) | benign(0.172) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
HIST1H2BC | SNV | Missense_Mutation | c.161N>C | p.Gly54Ala | p.G54A | P62807 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.813) | TCGA-A8-A09V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
HIST1H2BC | SNV | Missense_Mutation | c.340N>A | p.Glu114Lys | p.E114K | P62807 | protein_coding | tolerated_low_confidence(0.07) | benign(0.031) | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
HIST1H2BC | SNV | Missense_Mutation | c.308N>C | p.Leu103Pro | p.L103P | P62807 | protein_coding | deleterious_low_confidence(0.01) | benign(0.43) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
HIST1H2BC | SNV | Missense_Mutation | c.259N>A | p.Arg87Ser | p.R87S | P62807 | protein_coding | deleterious_low_confidence(0.01) | benign(0.14) | TCGA-D8-A1XF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
HIST1H2BC | SNV | Missense_Mutation | c.374C>T | p.Ser125Phe | p.S125F | P62807 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.95) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
HIST1H2BC | SNV | Missense_Mutation | c.133N>C | p.Val45Leu | p.V45L | P62807 | protein_coding | deleterious_low_confidence(0.02) | benign(0.033) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD | |
HIST1H2BC | SNV | Missense_Mutation | c.214N>C | p.Glu72Gln | p.E72Q | P62807 | protein_coding | deleterious_low_confidence(0.02) | benign(0.172) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
HIST1H2BC | SNV | Missense_Mutation | novel | c.108N>C | p.Glu36Asp | p.E36D | P62807 | protein_coding | deleterious_low_confidence(0.02) | benign(0.047) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2BC | SNV | Missense_Mutation | c.222N>G | p.Ile74Met | p.I74M | P62807 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.957) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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