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Gene: HBEGF |
Gene summary for HBEGF |
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Gene information | Species | Human | Gene symbol | HBEGF | Gene ID | 1839 |
Gene name | heparin binding EGF like growth factor | |
Gene Alias | DTR | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | Q99075 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1839 | HBEGF | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 6.18e-05 | 1.12e+00 | -0.23 |
1839 | HBEGF | 047563_1562-all-cells | Human | Prostate | BPH | 5.47e-18 | -5.08e-01 | 0.0791 |
1839 | HBEGF | 052095_1628-all-cells | Human | Prostate | BPH | 8.93e-17 | -5.88e-01 | 0.1032 |
1839 | HBEGF | 052097_1595-all-cells | Human | Prostate | BPH | 4.53e-05 | -2.72e-01 | 0.0972 |
1839 | HBEGF | Dong_P1 | Human | Prostate | Tumor | 3.14e-27 | -2.93e-01 | 0.035 |
1839 | HBEGF | Dong_P3 | Human | Prostate | Tumor | 1.12e-15 | -6.47e-01 | 0.0278 |
1839 | HBEGF | Dong_P4 | Human | Prostate | Tumor | 3.58e-06 | -2.95e-01 | 0.0292 |
1839 | HBEGF | Dong_P5 | Human | Prostate | Tumor | 2.80e-27 | -7.17e-01 | 0.053 |
1839 | HBEGF | P7 | Human | Prostate | Tumor | 9.79e-04 | 2.96e-01 | -0.1025 |
1839 | HBEGF | P1_S1_AK | Human | Skin | AK | 7.53e-07 | 3.93e-01 | -0.3399 |
1839 | HBEGF | P2_S3_AK | Human | Skin | AK | 1.89e-02 | 2.46e-01 | -0.3287 |
1839 | HBEGF | P2_S4_SCCIS | Human | Skin | SCCIS | 1.34e-26 | 7.06e-01 | -0.3043 |
1839 | HBEGF | P4_S8_cSCC | Human | Skin | cSCC | 4.98e-08 | 4.49e-01 | -0.3095 |
1839 | HBEGF | P5_S10_cSCC | Human | Skin | cSCC | 6.41e-48 | 8.55e-01 | -0.299 |
1839 | HBEGF | cSCC_p10 | Human | Skin | cSCC | 1.29e-05 | 2.70e-01 | -0.2095 |
1839 | HBEGF | Adj_PTCwithHT_6 | Human | Thyroid | HT | 2.46e-10 | -6.34e-01 | 0.02 |
1839 | HBEGF | Adj_PTCwithHT_8 | Human | Thyroid | HT | 4.19e-02 | -5.07e-01 | 0.0267 |
1839 | HBEGF | PTCwithHT_6 | Human | Thyroid | HT | 6.76e-06 | -4.74e-01 | 0.02 |
1839 | HBEGF | male-WTA | Human | Thyroid | PTC | 1.52e-26 | -4.48e-01 | 0.1037 |
1839 | HBEGF | PTC06 | Human | Thyroid | PTC | 2.59e-04 | 7.07e-01 | 0.2057 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
GO:00603267 | Cervix | CC | cell chemotaxis | 73/2311 | 310/18723 | 2.82e-08 | 1.96e-06 | 73 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
GO:00443193 | Cervix | CC | wound healing, spreading of cells | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
GO:00905053 | Cervix | CC | epiboly involved in wound healing | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
GO:00905043 | Cervix | CC | epiboly | 17/2311 | 35/18723 | 1.70e-07 | 7.93e-06 | 17 |
GO:00106349 | Cervix | CC | positive regulation of epithelial cell migration | 47/2311 | 176/18723 | 1.73e-07 | 8.01e-06 | 47 |
GO:19030349 | Cervix | CC | regulation of response to wounding | 44/2311 | 167/18723 | 6.33e-07 | 2.31e-05 | 44 |
GO:00020111 | Cervix | CC | morphogenesis of an epithelial sheet | 21/2311 | 57/18723 | 1.91e-06 | 5.97e-05 | 21 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00610418 | Cervix | CC | regulation of wound healing | 34/2311 | 134/18723 | 2.70e-05 | 4.52e-04 | 34 |
GO:19030368 | Cervix | CC | positive regulation of response to wounding | 21/2311 | 72/18723 | 1.10e-04 | 1.39e-03 | 21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0491520 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa051207 | Cervix | CC | Epithelial cell signaling in Helicobacter pylori infection | 24/1267 | 70/8465 | 4.35e-05 | 3.09e-04 | 1.83e-04 | 24 |
hsa04915110 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa0512014 | Cervix | CC | Epithelial cell signaling in Helicobacter pylori infection | 24/1267 | 70/8465 | 4.35e-05 | 3.09e-04 | 1.83e-04 | 24 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0491524 | Cervix | HSIL_HPV | Estrogen signaling pathway | 19/459 | 138/8465 | 1.54e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0491534 | Cervix | HSIL_HPV | Estrogen signaling pathway | 19/459 | 138/8465 | 1.54e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa0517139 | Esophagus | HGIN | Coronavirus disease - COVID-19 | 105/1383 | 232/8465 | 7.84e-26 | 5.11e-24 | 4.06e-24 | 105 |
hsa0520528 | Esophagus | HGIN | Proteoglycans in cancer | 47/1383 | 205/8465 | 8.23e-03 | 4.71e-02 | 3.74e-02 | 47 |
hsa05171115 | Esophagus | HGIN | Coronavirus disease - COVID-19 | 105/1383 | 232/8465 | 7.84e-26 | 5.11e-24 | 4.06e-24 | 105 |
hsa05205112 | Esophagus | HGIN | Proteoglycans in cancer | 47/1383 | 205/8465 | 8.23e-03 | 4.71e-02 | 3.74e-02 | 47 |
hsa05171211 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0521910 | Esophagus | ESCC | Bladder cancer | 35/4205 | 41/8465 | 1.91e-06 | 1.15e-05 | 5.87e-06 | 35 |
hsa0512018 | Esophagus | ESCC | Epithelial cell signaling in Helicobacter pylori infection | 52/4205 | 70/8465 | 2.17e-05 | 1.07e-04 | 5.47e-05 | 52 |
hsa0401218 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa015227 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa05171310 | Esophagus | ESCC | Coronavirus disease - COVID-19 | 156/4205 | 232/8465 | 3.18e-08 | 2.68e-07 | 1.37e-07 | 156 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
HBEGF | EGFR | HBEGF_EGFR | EGF | Breast | ADJ |
HBEGF | EGFR | HBEGF_EGFR | EGF | Breast | DCIS |
HBEGF | EGFR_ERBB2 | HBEGF_EGFR_ERBB2 | EGF | Breast | DCIS |
HBEGF | EGFR | HBEGF_EGFR | EGF | Breast | Healthy |
HBEGF | EGFR | HBEGF_EGFR | EGF | Breast | Precancer |
HBEGF | EGFR | HBEGF_EGFR | EGF | Cervix | ADJ |
HBEGF | EGFR | HBEGF_EGFR | EGF | Cervix | CC |
HBEGF | EGFR_ERBB2 | HBEGF_EGFR_ERBB2 | EGF | Cervix | CC |
HBEGF | ERBB4 | HBEGF_ERBB4 | EGF | Cervix | CC |
HBEGF | ERBB2_ERBB4 | HBEGF_ERBB2_ERBB4 | EGF | Cervix | CC |
HBEGF | EGFR | HBEGF_EGFR | EGF | Cervix | Healthy |
HBEGF | EGFR | HBEGF_EGFR | EGF | Cervix | Precancer |
HBEGF | EGFR | HBEGF_EGFR | EGF | CRC | MSS |
HBEGF | EGFR_ERBB2 | HBEGF_EGFR_ERBB2 | EGF | CRC | MSS |
HBEGF | EGFR | HBEGF_EGFR | EGF | Endometrium | ADJ |
HBEGF | ERBB4 | HBEGF_ERBB4 | EGF | Endometrium | ADJ |
HBEGF | EGFR | HBEGF_EGFR | EGF | Endometrium | AEH |
HBEGF | ERBB4 | HBEGF_ERBB4 | EGF | Endometrium | AEH |
HBEGF | EGFR | HBEGF_EGFR | EGF | Endometrium | EEC |
HBEGF | ERBB4 | HBEGF_ERBB4 | EGF | Endometrium | EEC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HBEGF | SNV | Missense_Mutation | novel | c.70N>A | p.Glu24Lys | p.E24K | Q99075 | protein_coding | tolerated(0.08) | benign(0.054) | TCGA-E9-A1R4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
HBEGF | SNV | Missense_Mutation | c.466N>G | p.Thr156Ala | p.T156A | Q99075 | protein_coding | tolerated(0.52) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HBEGF | SNV | Missense_Mutation | novel | c.458G>A | p.Arg153His | p.R153H | Q99075 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HBEGF | SNV | Missense_Mutation | c.473N>G | p.Asp158Gly | p.D158G | Q99075 | protein_coding | deleterious(0.01) | possibly_damaging(0.696) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HBEGF | SNV | Missense_Mutation | novel | c.298N>T | p.Gly100Trp | p.G100W | Q99075 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HBEGF | SNV | Missense_Mutation | novel | c.298N>T | p.Gly100Trp | p.G100W | Q99075 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HBEGF | SNV | Missense_Mutation | novel | c.5N>C | p.Lys2Thr | p.K2T | Q99075 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.981) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HBEGF | SNV | Missense_Mutation | c.160N>A | p.Gly54Arg | p.G54R | Q99075 | protein_coding | tolerated(0.37) | benign(0.134) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HBEGF | SNV | Missense_Mutation | novel | c.41N>T | p.Ala14Val | p.A14V | Q99075 | protein_coding | tolerated(0.13) | benign(0.432) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HBEGF | SNV | Missense_Mutation | c.382N>T | p.Arg128Trp | p.R128W | Q99075 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1839 | HBEGF | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME | cetuximab | CETUXIMAB | ||
1839 | HBEGF | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME | ANTISERUM | 7538797 | ||
1839 | HBEGF | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME | U3-1565 | |||
1839 | HBEGF | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME | panitumumab | PANITUMUMAB | ||
1839 | HBEGF | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME | KHK-2866 | KHK-2866 |
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