|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: H3F3B |
Gene summary for H3F3B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | H3F3B | Gene ID | 3021 |
| Gene name | H3.3 histone B | |
| Gene Alias | H3-3A | |
| Cytomap | 17q25.1 | |
| Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | B2R4P9 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3021 | H3F3B | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.94e-11 | -2.98e-01 | 0.0674 |
| 3021 | H3F3B | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.81e-03 | -2.98e-01 | 0.0588 |
| 3021 | H3F3B | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.63e-48 | 1.56e+00 | 0.294 |
| 3021 | H3F3B | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.09e-13 | 2.01e+00 | 0.3487 |
| 3021 | H3F3B | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.65e-40 | 2.10e+00 | 0.281 |
| 3021 | H3F3B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.60e-46 | 1.56e+00 | 0.3859 |
| 3021 | H3F3B | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.35e-21 | 1.28e+00 | 0.2585 |
| 3021 | H3F3B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.48e-54 | 1.37e+00 | 0.3005 |
| 3021 | H3F3B | A015-C-203 | Human | Colorectum | FAP | 9.65e-04 | -1.66e-01 | -0.1294 |
| 3021 | H3F3B | A001-C-119 | Human | Colorectum | FAP | 2.98e-02 | -2.27e-01 | -0.1557 |
| 3021 | H3F3B | A001-C-108 | Human | Colorectum | FAP | 2.17e-03 | -1.85e-01 | -0.0272 |
| 3021 | H3F3B | A002-C-205 | Human | Colorectum | FAP | 1.26e-03 | -1.99e-01 | -0.1236 |
| 3021 | H3F3B | A015-C-006 | Human | Colorectum | FAP | 8.13e-03 | -2.09e-01 | -0.0994 |
| 3021 | H3F3B | A002-C-114 | Human | Colorectum | FAP | 1.66e-03 | -2.16e-01 | -0.1561 |
| 3021 | H3F3B | A015-C-104 | Human | Colorectum | FAP | 5.95e-05 | -1.35e-01 | -0.1899 |
| 3021 | H3F3B | A015-C-202 | Human | Colorectum | FAP | 2.10e-03 | -2.52e-01 | -0.0849 |
| 3021 | H3F3B | A001-C-203 | Human | Colorectum | FAP | 2.47e-03 | -2.01e-01 | -0.0481 |
| 3021 | H3F3B | A002-C-116 | Human | Colorectum | FAP | 1.55e-02 | -1.17e-01 | -0.0452 |
| 3021 | H3F3B | A014-C-008 | Human | Colorectum | FAP | 6.33e-03 | -2.58e-01 | -0.191 |
| 3021 | H3F3B | A018-E-020 | Human | Colorectum | FAP | 1.08e-02 | -1.27e-01 | -0.2034 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
| hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
| hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
| hsa0513125 | Cervix | HSIL_HPV | Shigellosis | 27/459 | 247/8465 | 3.78e-04 | 3.49e-03 | 2.82e-03 | 27 |
| hsa053221 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
| hsa0513135 | Cervix | HSIL_HPV | Shigellosis | 27/459 | 247/8465 | 3.78e-04 | 3.49e-03 | 2.82e-03 | 27 |
| hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| H3F3B | SNV | Missense_Mutation | novel | c.292N>A | p.Glu98Lys | p.E98K | P84243 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.817) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
| H3F3B | SNV | Missense_Mutation | rs11547396 | c.122G>A | p.Arg41His | p.R41H | P84243 | protein_coding | tolerated_low_confidence(0.09) | benign(0.001) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| H3F3B | SNV | Missense_Mutation | c.142N>A | p.Ala48Thr | p.A48T | P84243 | protein_coding | deleterious_low_confidence(0.03) | benign(0.011) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| H3F3B | SNV | Missense_Mutation | novel | c.200N>T | p.Pro67Leu | p.P67L | P84243 | protein_coding | deleterious_low_confidence(0.01) | benign(0.111) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| H3F3B | SNV | Missense_Mutation | novel | c.176N>T | p.Thr59Ile | p.T59I | P84243 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.792) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| H3F3B | SNV | Missense_Mutation | novel | c.199N>T | p.Pro67Ser | p.P67S | P84243 | protein_coding | deleterious_low_confidence(0.02) | benign(0.047) | TCGA-D1-A2G0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| H3F3B | SNV | Missense_Mutation | c.262G>A | p.Ala88Thr | p.A88T | P84243 | protein_coding | tolerated_low_confidence(0.16) | benign(0.023) | TCGA-44-6778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| H3F3B | SNV | Missense_Mutation | novel | c.379N>G | p.Leu127Val | p.L127V | P84243 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.999) | TCGA-50-6591-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| H3F3B | SNV | Missense_Mutation | c.79N>G | p.Arg27Gly | p.R27G | P84243 | protein_coding | deleterious_low_confidence(0.03) | benign(0.001) | TCGA-21-5784-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| H3F3B | SNV | Missense_Mutation | novel | c.258G>T | p.Gln86His | p.Q86H | P84243 | protein_coding | deleterious_low_confidence(0) | benign(0.091) | TCGA-37-3792-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |