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Gene: GTPBP3 |
Gene summary for GTPBP3 |
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Gene information | Species | Human | Gene symbol | GTPBP3 | Gene ID | 84705 |
Gene name | GTP binding protein 3, mitochondrial | |
Gene Alias | COXPD23 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | B7Z563 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84705 | GTPBP3 | C21 | Human | Oral cavity | OSCC | 8.03e-09 | 3.64e-01 | 0.2678 |
84705 | GTPBP3 | C30 | Human | Oral cavity | OSCC | 1.19e-21 | 8.88e-01 | 0.3055 |
84705 | GTPBP3 | C38 | Human | Oral cavity | OSCC | 1.07e-03 | 4.94e-01 | 0.172 |
84705 | GTPBP3 | C43 | Human | Oral cavity | OSCC | 3.86e-16 | 2.76e-01 | 0.1704 |
84705 | GTPBP3 | C46 | Human | Oral cavity | OSCC | 7.24e-11 | 3.49e-01 | 0.1673 |
84705 | GTPBP3 | C08 | Human | Oral cavity | OSCC | 8.06e-11 | 2.48e-01 | 0.1919 |
84705 | GTPBP3 | LN46 | Human | Oral cavity | OSCC | 9.40e-03 | 2.25e-01 | 0.1666 |
84705 | GTPBP3 | SYSMH1 | Human | Oral cavity | OSCC | 4.32e-03 | 1.45e-01 | 0.1127 |
84705 | GTPBP3 | SYSMH2 | Human | Oral cavity | OSCC | 2.17e-04 | 2.71e-01 | 0.2326 |
84705 | GTPBP3 | SYSMH3 | Human | Oral cavity | OSCC | 7.12e-20 | 4.78e-01 | 0.2442 |
84705 | GTPBP3 | SYSMH5 | Human | Oral cavity | OSCC | 2.76e-03 | 1.33e-01 | 0.0647 |
84705 | GTPBP3 | SYSMH6 | Human | Oral cavity | OSCC | 4.37e-03 | 9.89e-02 | 0.1275 |
84705 | GTPBP3 | male-WTA | Human | Thyroid | PTC | 2.63e-05 | 1.02e-01 | 0.1037 |
84705 | GTPBP3 | PTC01 | Human | Thyroid | PTC | 2.35e-02 | 6.64e-02 | 0.1899 |
84705 | GTPBP3 | PTC05 | Human | Thyroid | PTC | 3.22e-06 | 2.22e-01 | 0.2065 |
84705 | GTPBP3 | PTC06 | Human | Thyroid | PTC | 7.65e-10 | 2.70e-01 | 0.2057 |
84705 | GTPBP3 | PTC07 | Human | Thyroid | PTC | 6.92e-11 | 1.86e-01 | 0.2044 |
84705 | GTPBP3 | ATC12 | Human | Thyroid | ATC | 6.59e-05 | 1.40e-01 | 0.34 |
84705 | GTPBP3 | ATC13 | Human | Thyroid | ATC | 7.41e-18 | 2.74e-01 | 0.34 |
84705 | GTPBP3 | ATC2 | Human | Thyroid | ATC | 4.20e-08 | 6.46e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:0030488 | Liver | HCC | tRNA methylation | 29/7958 | 41/18723 | 2.38e-04 | 1.79e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP3 | SNV | Missense_Mutation | c.18N>C | p.Trp6Cys | p.W6C | Q969Y2 | protein_coding | deleterious_low_confidence(0.04) | benign(0.443) | TCGA-A2-A04X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
GTPBP3 | SNV | Missense_Mutation | novel | c.905N>T | p.Ser302Ile | p.S302I | Q969Y2 | protein_coding | tolerated(0.07) | possibly_damaging(0.843) | TCGA-A2-A25E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
GTPBP3 | SNV | Missense_Mutation | novel | c.104N>A | p.Thr35Asn | p.T35N | Q969Y2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A2-A4S1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTPBP3 | SNV | Missense_Mutation | novel | c.1054N>T | p.Arg352Trp | p.R352W | Q969Y2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
GTPBP3 | SNV | Missense_Mutation | rs751380465 | c.1063N>T | p.Arg355Trp | p.R355W | Q969Y2 | protein_coding | deleterious(0.04) | benign(0.027) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP3 | SNV | Missense_Mutation | c.448N>G | p.Asn150Asp | p.N150D | Q969Y2 | protein_coding | tolerated(0.23) | benign(0.135) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
GTPBP3 | SNV | Missense_Mutation | c.579N>C | p.Glu193Asp | p.E193D | Q969Y2 | protein_coding | tolerated(0.17) | benign(0.009) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP3 | deletion | Frame_Shift_Del | novel | c.654delN | p.Leu219TrpfsTer66 | p.L219Wfs*66 | Q969Y2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GTPBP3 | SNV | Missense_Mutation | novel | c.1496N>G | p.His499Arg | p.H499R | Q969Y2 | protein_coding | tolerated(0.07) | benign(0.242) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
GTPBP3 | SNV | Missense_Mutation | c.1259N>A | p.Pro420His | p.P420H | Q969Y2 | protein_coding | tolerated(0.11) | possibly_damaging(0.78) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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