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Gene: GPR87 |
Gene summary for GPR87 |
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Gene information | Species | Human | Gene symbol | GPR87 | Gene ID | 53836 |
Gene name | G protein-coupled receptor 87 | |
Gene Alias | FKSG78 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q9BY21 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
53836 | GPR87 | P107T-E | Human | Esophagus | ESCC | 1.96e-24 | 8.49e-01 | 0.171 |
53836 | GPR87 | P127T-E | Human | Esophagus | ESCC | 2.90e-14 | 3.39e-01 | 0.0826 |
53836 | GPR87 | P128T-E | Human | Esophagus | ESCC | 4.80e-15 | 4.94e-01 | 0.1241 |
53836 | GPR87 | P130T-E | Human | Esophagus | ESCC | 5.22e-38 | 1.23e+00 | 0.1676 |
53836 | GPR87 | C04 | Human | Oral cavity | OSCC | 1.16e-22 | 1.56e+00 | 0.2633 |
53836 | GPR87 | C21 | Human | Oral cavity | OSCC | 9.31e-73 | 2.23e+00 | 0.2678 |
53836 | GPR87 | C30 | Human | Oral cavity | OSCC | 8.27e-58 | 2.78e+00 | 0.3055 |
53836 | GPR87 | C38 | Human | Oral cavity | OSCC | 1.85e-06 | 9.50e-01 | 0.172 |
53836 | GPR87 | C43 | Human | Oral cavity | OSCC | 2.73e-35 | 6.81e-01 | 0.1704 |
53836 | GPR87 | C46 | Human | Oral cavity | OSCC | 7.16e-14 | 4.29e-01 | 0.1673 |
53836 | GPR87 | C51 | Human | Oral cavity | OSCC | 1.02e-22 | 1.24e+00 | 0.2674 |
53836 | GPR87 | C57 | Human | Oral cavity | OSCC | 1.87e-31 | 1.00e+00 | 0.1679 |
53836 | GPR87 | C06 | Human | Oral cavity | OSCC | 3.94e-11 | 2.01e+00 | 0.2699 |
53836 | GPR87 | C08 | Human | Oral cavity | OSCC | 1.04e-49 | 1.18e+00 | 0.1919 |
53836 | GPR87 | C09 | Human | Oral cavity | OSCC | 8.11e-06 | 3.58e-01 | 0.1431 |
53836 | GPR87 | LN22 | Human | Oral cavity | OSCC | 1.75e-04 | 8.40e-01 | 0.1733 |
53836 | GPR87 | LN38 | Human | Oral cavity | OSCC | 8.39e-03 | 7.49e-01 | 0.168 |
53836 | GPR87 | LN46 | Human | Oral cavity | OSCC | 4.78e-07 | 4.55e-01 | 0.1666 |
53836 | GPR87 | LP15 | Human | Oral cavity | LP | 4.41e-10 | 2.08e+00 | 0.2174 |
53836 | GPR87 | LP17 | Human | Oral cavity | LP | 5.47e-04 | 8.01e-01 | 0.2349 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR87 | SNV | Missense_Mutation | rs765905861 | c.17C>T | p.Thr6Met | p.T6M | Q9BY21 | protein_coding | deleterious_low_confidence(0.02) | benign(0.178) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
GPR87 | SNV | Missense_Mutation | c.299A>G | p.His100Arg | p.H100R | Q9BY21 | protein_coding | tolerated(0.34) | benign(0) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GPR87 | SNV | Missense_Mutation | novel | c.853N>C | p.Asp285His | p.D285H | Q9BY21 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GPR87 | insertion | Frame_Shift_Ins | novel | c.359_360insAA | p.Phe121SerfsTer15 | p.F121Sfs*15 | Q9BY21 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GPR87 | SNV | Missense_Mutation | c.168N>A | p.Ser56Arg | p.S56R | Q9BY21 | protein_coding | deleterious(0) | possibly_damaging(0.806) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GPR87 | SNV | Missense_Mutation | c.371N>G | p.Asn124Ser | p.N124S | Q9BY21 | protein_coding | tolerated(0.27) | benign(0.026) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
GPR87 | SNV | Missense_Mutation | c.929N>C | p.Asp310Ala | p.D310A | Q9BY21 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GPR87 | SNV | Missense_Mutation | rs778550664 | c.911C>T | p.Ala304Val | p.A304V | Q9BY21 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-A01Z-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GPR87 | SNV | Missense_Mutation | novel | c.890N>G | p.Glu297Gly | p.E297G | Q9BY21 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GPR87 | SNV | Missense_Mutation | rs777076331 | c.652N>A | p.Val218Met | p.V218M | Q9BY21 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
53836 | GPR87 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650457 | ||
53836 | GPR87 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650190 | ||
53836 | GPR87 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651509 |
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