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Gene: GPR108 |
Gene summary for GPR108 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GPR108 | Gene ID | 56927 |
Gene name | G protein-coupled receptor 108 | |
Gene Alias | LUSTR2 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0002221 | UniProtAcc | Q9NPR9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56927 | GPR108 | P40T-E | Human | Esophagus | ESCC | 4.47e-16 | 2.67e-01 | 0.109 |
56927 | GPR108 | P42T-E | Human | Esophagus | ESCC | 3.08e-26 | 7.29e-01 | 0.1175 |
56927 | GPR108 | P44T-E | Human | Esophagus | ESCC | 1.32e-16 | 4.83e-01 | 0.1096 |
56927 | GPR108 | P47T-E | Human | Esophagus | ESCC | 1.21e-16 | 3.12e-01 | 0.1067 |
56927 | GPR108 | P48T-E | Human | Esophagus | ESCC | 1.13e-24 | 4.16e-01 | 0.0959 |
56927 | GPR108 | P49T-E | Human | Esophagus | ESCC | 2.95e-11 | 9.92e-01 | 0.1768 |
56927 | GPR108 | P52T-E | Human | Esophagus | ESCC | 1.71e-26 | 5.25e-01 | 0.1555 |
56927 | GPR108 | P54T-E | Human | Esophagus | ESCC | 7.15e-30 | 6.37e-01 | 0.0975 |
56927 | GPR108 | P56T-E | Human | Esophagus | ESCC | 7.10e-04 | 7.72e-01 | 0.1613 |
56927 | GPR108 | P57T-E | Human | Esophagus | ESCC | 4.36e-23 | 4.69e-01 | 0.0926 |
56927 | GPR108 | P61T-E | Human | Esophagus | ESCC | 9.40e-26 | 7.07e-01 | 0.099 |
56927 | GPR108 | P62T-E | Human | Esophagus | ESCC | 8.76e-71 | 1.27e+00 | 0.1302 |
56927 | GPR108 | P65T-E | Human | Esophagus | ESCC | 3.98e-14 | 3.96e-01 | 0.0978 |
56927 | GPR108 | P74T-E | Human | Esophagus | ESCC | 6.40e-31 | 8.54e-01 | 0.1479 |
56927 | GPR108 | P75T-E | Human | Esophagus | ESCC | 8.86e-51 | 8.61e-01 | 0.1125 |
56927 | GPR108 | P76T-E | Human | Esophagus | ESCC | 1.52e-30 | 5.35e-01 | 0.1207 |
56927 | GPR108 | P79T-E | Human | Esophagus | ESCC | 7.94e-15 | 2.46e-01 | 0.1154 |
56927 | GPR108 | P80T-E | Human | Esophagus | ESCC | 1.26e-33 | 9.79e-01 | 0.155 |
56927 | GPR108 | P82T-E | Human | Esophagus | ESCC | 1.30e-17 | 1.22e+00 | 0.1072 |
56927 | GPR108 | P83T-E | Human | Esophagus | ESCC | 6.74e-41 | 1.16e+00 | 0.1738 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002221 | Colorectum | MSS | pattern recognition receptor signaling pathway | 45/3467 | 172/18723 | 8.06e-03 | 4.91e-02 | 45 |
GO:00022211 | Liver | HCC | pattern recognition receptor signaling pathway | 107/7958 | 172/18723 | 1.37e-07 | 2.58e-06 | 107 |
GO:0002224 | Liver | HCC | toll-like receptor signaling pathway | 67/7958 | 121/18723 | 2.87e-03 | 1.34e-02 | 67 |
GO:00622072 | Liver | HCC | regulation of pattern recognition receptor signaling pathway | 59/7958 | 105/18723 | 3.18e-03 | 1.47e-02 | 59 |
GO:00022214 | Oral cavity | OSCC | pattern recognition receptor signaling pathway | 95/7305 | 172/18723 | 1.11e-05 | 1.15e-04 | 95 |
GO:00622076 | Oral cavity | OSCC | regulation of pattern recognition receptor signaling pathway | 56/7305 | 105/18723 | 1.99e-03 | 9.23e-03 | 56 |
GO:00022243 | Oral cavity | OSCC | toll-like receptor signaling pathway | 63/7305 | 121/18723 | 2.36e-03 | 1.04e-02 | 63 |
GO:00027646 | Oral cavity | OSCC | immune response-regulating signaling pathway | 212/7305 | 468/18723 | 2.93e-03 | 1.27e-02 | 212 |
GO:00022215 | Thyroid | PTC | pattern recognition receptor signaling pathway | 77/5968 | 172/18723 | 2.56e-04 | 1.84e-03 | 77 |
GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GPR108 | SNV | Missense_Mutation | rs757468810 | c.1363N>A | p.Val455Ile | p.V455I | Q9NPR9 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
GPR108 | SNV | Missense_Mutation | rs376404694 | c.625N>A | p.Val209Met | p.V209M | Q9NPR9 | protein_coding | tolerated(0.44) | benign(0.048) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GPR108 | SNV | Missense_Mutation | novel | c.951N>G | p.Ile317Met | p.I317M | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
GPR108 | deletion | Frame_Shift_Del | novel | c.683delN | p.Asn228ThrfsTer15 | p.N228Tfs*15 | Q9NPR9 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GPR108 | SNV | Missense_Mutation | novel | c.1095N>C | p.Lys365Asn | p.K365N | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GPR108 | SNV | Missense_Mutation | novel | c.1264N>T | p.Arg422Trp | p.R422W | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
GPR108 | SNV | Missense_Mutation | c.209G>A | p.Gly70Asp | p.G70D | Q9NPR9 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
GPR108 | SNV | Missense_Mutation | c.1568A>G | p.Asp523Gly | p.D523G | Q9NPR9 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GPR108 | SNV | Missense_Mutation | rs746123266 | c.857N>T | p.Thr286Met | p.T286M | Q9NPR9 | protein_coding | deleterious(0.02) | possibly_damaging(0.806) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GPR108 | SNV | Missense_Mutation | rs769102342 | c.973N>A | p.Glu325Lys | p.E325K | Q9NPR9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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