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Gene: GORASP2 |
Gene summary for GORASP2 |
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Gene information | Species | Human | Gene symbol | GORASP2 | Gene ID | 26003 |
Gene name | golgi reassembly stacking protein 2 | |
Gene Alias | GOLPH6 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H8Y8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26003 | GORASP2 | P42T-E | Human | Esophagus | ESCC | 6.25e-28 | 1.01e+00 | 0.1175 |
26003 | GORASP2 | P44T-E | Human | Esophagus | ESCC | 5.59e-16 | 6.44e-01 | 0.1096 |
26003 | GORASP2 | P47T-E | Human | Esophagus | ESCC | 1.81e-29 | 7.24e-01 | 0.1067 |
26003 | GORASP2 | P48T-E | Human | Esophagus | ESCC | 1.11e-19 | 5.11e-01 | 0.0959 |
26003 | GORASP2 | P49T-E | Human | Esophagus | ESCC | 2.00e-20 | 2.09e+00 | 0.1768 |
26003 | GORASP2 | P52T-E | Human | Esophagus | ESCC | 1.28e-28 | 8.58e-01 | 0.1555 |
26003 | GORASP2 | P54T-E | Human | Esophagus | ESCC | 2.41e-21 | 6.70e-01 | 0.0975 |
26003 | GORASP2 | P56T-E | Human | Esophagus | ESCC | 3.96e-10 | 1.93e+00 | 0.1613 |
26003 | GORASP2 | P57T-E | Human | Esophagus | ESCC | 1.00e-24 | 6.11e-01 | 0.0926 |
26003 | GORASP2 | P61T-E | Human | Esophagus | ESCC | 1.29e-22 | 7.91e-01 | 0.099 |
26003 | GORASP2 | P62T-E | Human | Esophagus | ESCC | 1.93e-81 | 1.30e+00 | 0.1302 |
26003 | GORASP2 | P65T-E | Human | Esophagus | ESCC | 2.22e-25 | 6.48e-01 | 0.0978 |
26003 | GORASP2 | P74T-E | Human | Esophagus | ESCC | 2.07e-42 | 1.23e+00 | 0.1479 |
26003 | GORASP2 | P75T-E | Human | Esophagus | ESCC | 1.52e-62 | 1.58e+00 | 0.1125 |
26003 | GORASP2 | P76T-E | Human | Esophagus | ESCC | 1.07e-51 | 1.11e+00 | 0.1207 |
26003 | GORASP2 | P79T-E | Human | Esophagus | ESCC | 2.56e-59 | 1.21e+00 | 0.1154 |
26003 | GORASP2 | P80T-E | Human | Esophagus | ESCC | 5.27e-50 | 1.51e+00 | 0.155 |
26003 | GORASP2 | P82T-E | Human | Esophagus | ESCC | 1.42e-28 | 1.61e+00 | 0.1072 |
26003 | GORASP2 | P83T-E | Human | Esophagus | ESCC | 1.12e-51 | 1.54e+00 | 0.1738 |
26003 | GORASP2 | P84T-E | Human | Esophagus | ESCC | 5.95e-17 | 8.78e-01 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0061951 | Colorectum | AD | establishment of protein localization to plasma membrane | 31/3918 | 60/18723 | 1.37e-07 | 6.42e-06 | 31 |
GO:00349763 | Colorectum | MSI-H | response to endoplasmic reticulum stress | 39/1319 | 256/18723 | 4.12e-06 | 2.20e-04 | 39 |
GO:00726593 | Colorectum | MSI-H | protein localization to plasma membrane | 38/1319 | 284/18723 | 1.03e-04 | 3.18e-03 | 38 |
GO:19907783 | Colorectum | MSI-H | protein localization to cell periphery | 40/1319 | 333/18723 | 6.61e-04 | 1.27e-02 | 40 |
GO:00901503 | Colorectum | MSI-H | establishment of protein localization to membrane | 32/1319 | 260/18723 | 1.47e-03 | 2.23e-02 | 32 |
GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00619513 | Colorectum | FAP | establishment of protein localization to plasma membrane | 24/2622 | 60/18723 | 6.30e-07 | 3.09e-05 | 24 |
GO:00349764 | Colorectum | FAP | response to endoplasmic reticulum stress | 61/2622 | 256/18723 | 1.58e-05 | 4.10e-04 | 61 |
GO:00726595 | Colorectum | CRC | protein localization to plasma membrane | 80/2078 | 284/18723 | 1.36e-15 | 4.07e-12 | 80 |
GO:19907785 | Colorectum | CRC | protein localization to cell periphery | 85/2078 | 333/18723 | 8.75e-14 | 1.05e-10 | 85 |
GO:00619514 | Colorectum | CRC | establishment of protein localization to plasma membrane | 22/2078 | 60/18723 | 1.89e-07 | 1.92e-05 | 22 |
GO:00901505 | Colorectum | CRC | establishment of protein localization to membrane | 51/2078 | 260/18723 | 3.59e-05 | 9.05e-04 | 51 |
GO:003497625 | Esophagus | HGIN | response to endoplasmic reticulum stress | 81/2587 | 256/18723 | 1.47e-13 | 2.32e-11 | 81 |
GO:009015020 | Esophagus | HGIN | establishment of protein localization to membrane | 67/2587 | 260/18723 | 1.96e-07 | 9.57e-06 | 67 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GORASP2 | SNV | Missense_Mutation | c.553N>A | p.Gly185Ser | p.G185S | Q9H8Y8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
GORASP2 | SNV | Missense_Mutation | novel | c.1091N>C | p.Phe364Ser | p.F364S | Q9H8Y8 | protein_coding | tolerated(0.13) | benign(0.051) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GORASP2 | deletion | Frame_Shift_Del | c.1246delN | p.Thr418LeufsTer74 | p.T418Lfs*74 | Q9H8Y8 | protein_coding | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |||
GORASP2 | deletion | Frame_Shift_Del | novel | c.547delN | p.Ala183HisfsTer8 | p.A183Hfs*8 | Q9H8Y8 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
GORASP2 | SNV | Missense_Mutation | novel | c.302G>A | p.Arg101His | p.R101H | Q9H8Y8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GORASP2 | SNV | Missense_Mutation | c.65N>C | p.Val22Ala | p.V22A | Q9H8Y8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GORASP2 | SNV | Missense_Mutation | novel | c.106N>C | p.Phe36Leu | p.F36L | Q9H8Y8 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GORASP2 | SNV | Missense_Mutation | rs778067597 | c.1177G>A | p.Ala393Thr | p.A393T | Q9H8Y8 | protein_coding | tolerated_low_confidence(0.39) | benign(0.009) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GORASP2 | SNV | Missense_Mutation | c.397A>G | p.Ser133Gly | p.S133G | Q9H8Y8 | protein_coding | deleterious(0.01) | benign(0.088) | TCGA-AY-A71X-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GORASP2 | SNV | Missense_Mutation | novel | c.641N>A | p.Ser214Tyr | p.S214Y | Q9H8Y8 | protein_coding | deleterious(0.02) | benign(0.066) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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