|
Gene: GALNT4 |
Gene summary for GALNT4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GALNT4 | Gene ID | 8693 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 4 | |
Gene Alias | GALNAC-T4 | |
Cytomap | 12q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N4A0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8693 | GALNT4 | Pat17-B | Human | Stomach | GC | 8.81e-05 | 1.89e-01 | 0.3109 |
8693 | GALNT4 | Pat18-B | Human | Stomach | GC | 3.21e-21 | 4.05e-01 | -0.0432 |
8693 | GALNT4 | Pat19-B | Human | Stomach | GC | 6.57e-14 | 3.98e-01 | 0.0826 |
8693 | GALNT4 | Pat22-B | Human | Stomach | GC | 8.64e-17 | 3.09e-01 | -0.1042 |
8693 | GALNT4 | Pat24-B | Human | Stomach | GC | 2.57e-21 | 5.79e-01 | -0.1184 |
8693 | GALNT4 | Pat25-A | Human | Stomach | CAG with IM | 1.59e-22 | 3.95e-01 | -0.1648 |
8693 | GALNT4 | Pat26-A | Human | Stomach | CSG | 1.22e-15 | 3.32e-01 | -0.2402 |
8693 | GALNT4 | Pat28-A | Human | Stomach | CSG | 1.46e-12 | 3.44e-01 | -0.2594 |
8693 | GALNT4 | Pat29-A | Human | Stomach | CAG with IM | 6.84e-24 | 6.77e-01 | -0.2769 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0018210 | Colorectum | AD | peptidyl-threonine modification | 40/3918 | 125/18723 | 2.44e-03 | 1.88e-02 | 40 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:0006486 | Colorectum | AD | protein glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0043413 | Colorectum | AD | macromolecule glycosylation | 64/3918 | 226/18723 | 4.86e-03 | 3.27e-02 | 64 |
GO:0070085 | Colorectum | AD | glycosylation | 67/3918 | 240/18723 | 5.78e-03 | 3.67e-02 | 67 |
GO:00182091 | Colorectum | MSS | peptidyl-serine modification | 84/3467 | 338/18723 | 2.12e-03 | 1.79e-02 | 84 |
GO:00182101 | Colorectum | MSS | peptidyl-threonine modification | 36/3467 | 125/18723 | 3.28e-03 | 2.49e-02 | 36 |
GO:00182107 | Endometrium | AEH | peptidyl-threonine modification | 25/2100 | 125/18723 | 2.84e-03 | 2.04e-02 | 25 |
GO:001821013 | Endometrium | EEC | peptidyl-threonine modification | 28/2168 | 125/18723 | 4.23e-04 | 4.42e-03 | 28 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GALNT4 | insertion | Nonsense_Mutation | novel | c.1356_1357insTGAATGAATGACTGAATGAATGA | p.Ile453Ter | p.I453* | Q8N4A0 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GALNT4 | insertion | Frame_Shift_Ins | novel | c.1354_1355insCTTTCAGTAAGTG | p.Gly452AlafsTer9 | p.G452Afs*9 | Q8N4A0 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
GALNT4 | insertion | In_Frame_Ins | novel | c.855_856insCACATTAAA | p.Gln285_Trp286insHisIleLys | p.Q285_W286insHIK | Q8N4A0 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GALNT4 | SNV | Missense_Mutation | rs201726968 | c.5N>T | p.Ala2Val | p.A2V | Q8N4A0 | protein_coding | tolerated_low_confidence(0.18) | benign(0.011) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GALNT4 | SNV | Missense_Mutation | c.935N>A | p.Gly312Glu | p.G312E | Q8N4A0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GALNT4 | SNV | Missense_Mutation | c.912N>G | p.Ile304Met | p.I304M | Q8N4A0 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GALNT4 | SNV | Missense_Mutation | c.211N>G | p.Ser71Ala | p.S71A | Q8N4A0 | protein_coding | tolerated(0.2) | benign(0) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
GALNT4 | SNV | Missense_Mutation | novel | c.798N>A | p.Phe266Leu | p.F266L | Q8N4A0 | protein_coding | deleterious(0) | benign(0.411) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GALNT4 | SNV | Missense_Mutation | c.409N>G | p.Thr137Ala | p.T137A | Q8N4A0 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
GALNT4 | SNV | Missense_Mutation | c.361A>C | p.Met121Leu | p.M121L | Q8N4A0 | protein_coding | tolerated(0.69) | benign(0.001) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |