Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: G3BP1

Gene summary for G3BP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

G3BP1

Gene ID

10146

Gene nameG3BP stress granule assembly factor 1
Gene AliasG3BP
Cytomap5q33.1
Gene Typeprotein-coding
GO ID

GO:0001816

UniProtAcc

Q13283


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10146G3BP1P37T-EHumanEsophagusESCC1.90e-197.39e-010.1371
10146G3BP1P38T-EHumanEsophagusESCC2.86e-044.19e-010.127
10146G3BP1P39T-EHumanEsophagusESCC5.14e-082.87e-010.0894
10146G3BP1P40T-EHumanEsophagusESCC1.89e-075.08e-010.109
10146G3BP1P42T-EHumanEsophagusESCC8.91e-279.10e-010.1175
10146G3BP1P44T-EHumanEsophagusESCC2.59e-094.53e-010.1096
10146G3BP1P47T-EHumanEsophagusESCC7.89e-173.84e-010.1067
10146G3BP1P48T-EHumanEsophagusESCC1.73e-235.38e-010.0959
10146G3BP1P49T-EHumanEsophagusESCC3.86e-121.93e+000.1768
10146G3BP1P52T-EHumanEsophagusESCC1.89e-279.68e-010.1555
10146G3BP1P54T-EHumanEsophagusESCC8.74e-281.01e+000.0975
10146G3BP1P56T-EHumanEsophagusESCC9.11e-121.68e+000.1613
10146G3BP1P57T-EHumanEsophagusESCC9.47e-154.01e-010.0926
10146G3BP1P61T-EHumanEsophagusESCC3.62e-084.61e-010.099
10146G3BP1P62T-EHumanEsophagusESCC6.92e-711.56e+000.1302
10146G3BP1P65T-EHumanEsophagusESCC3.11e-213.60e-010.0978
10146G3BP1P74T-EHumanEsophagusESCC2.31e-331.46e+000.1479
10146G3BP1P75T-EHumanEsophagusESCC8.11e-298.06e-010.1125
10146G3BP1P76T-EHumanEsophagusESCC2.29e-298.16e-010.1207
10146G3BP1P79T-EHumanEsophagusESCC5.17e-409.06e-010.1154
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0030111ColorectumADregulation of Wnt signaling pathway102/3918328/187238.51e-062.03e-04102
GO:0007265ColorectumADRas protein signal transduction104/3918337/187231.01e-052.35e-04104
GO:0016055ColorectumADWnt signaling pathway130/3918444/187231.60e-053.37e-04130
GO:0198738ColorectumADcell-cell signaling by wnt130/3918446/187232.02e-054.10e-04130
GO:0060070ColorectumADcanonical Wnt signaling pathway90/3918303/187231.76e-042.38e-0390
GO:0060828ColorectumADregulation of canonical Wnt signaling pathway77/3918253/187232.19e-042.87e-0377
GO:0032481ColorectumADpositive regulation of type I interferon production23/391858/187238.82e-048.53e-0323
GO:0032392ColorectumADDNA geometric change31/391890/187232.02e-031.63e-0231
GO:00301112ColorectumMSSregulation of Wnt signaling pathway98/3467328/187233.37e-071.36e-0598
GO:00160552ColorectumMSSWnt signaling pathway124/3467444/187236.06e-072.26e-05124
GO:01987382ColorectumMSScell-cell signaling by wnt124/3467446/187237.83e-072.77e-05124
GO:00600702ColorectumMSScanonical Wnt signaling pathway86/3467303/187231.58e-053.56e-0486
GO:00608282ColorectumMSSregulation of canonical Wnt signaling pathway74/3467253/187231.99e-054.26e-0474
GO:00072651ColorectumMSSRas protein signal transduction91/3467337/187237.20e-051.21e-0391
GO:0030178ColorectumMSSnegative regulation of Wnt signaling pathway48/3467170/187231.23e-031.18e-0248
GO:00323921ColorectumMSSDNA geometric change29/346790/187231.26e-031.20e-0229
GO:00324811ColorectumMSSpositive regulation of type I interferon production20/346758/187232.82e-032.20e-0220
GO:0032508ColorectumMSSDNA duplex unwinding25/346784/187238.27e-034.99e-0225
GO:00160553ColorectumFAPWnt signaling pathway104/2622444/187234.92e-083.92e-06104
GO:01987383ColorectumFAPcell-cell signaling by wnt104/2622446/187236.26e-084.54e-06104
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
G3BP1SNVMissense_Mutationc.865N>Ap.Glu289Lysp.E289KQ13283protein_codingtolerated(0.06)benign(0.007)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
G3BP1SNVMissense_Mutationc.1247N>Ap.Arg416Glnp.R416QQ13283protein_codingtolerated(0.06)benign(0.058)TCGA-BH-A0B3-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
G3BP1SNVMissense_Mutationnovelc.460N>Cp.Glu154Glnp.E154QQ13283protein_codingdeleterious(0.02)probably_damaging(0.96)TCGA-BH-A0BA-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
G3BP1SNVMissense_Mutationc.1391N>Tp.Pro464Leup.P464LQ13283protein_codingdeleterious_low_confidence(0.01)benign(0.051)TCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
G3BP1SNVMissense_Mutationc.775C>Gp.Leu259Valp.L259VQ13283protein_codingtolerated(0.11)possibly_damaging(0.883)TCGA-E2-A159-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
G3BP1SNVMissense_Mutationc.901N>Gp.Gln301Glup.Q301EQ13283protein_codingtolerated(0.09)benign(0.001)TCGA-EW-A1PB-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
G3BP1SNVMissense_Mutationnovelc.649C>Gp.Pro217Alap.P217AQ13283protein_codingtolerated(0.45)benign(0)TCGA-5M-AAT4-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownPD
G3BP1SNVMissense_Mutationnovelc.488N>Ap.Pro163Hisp.P163HQ13283protein_codingdeleterious(0)probably_damaging(0.98)TCGA-A6-2672-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
G3BP1SNVMissense_Mutationc.344C>Tp.Ala115Valp.A115VQ13283protein_codingtolerated(0.08)benign(0.232)TCGA-AA-3663-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
G3BP1SNVMissense_Mutationc.1280G>Ap.Arg427Hisp.R427HQ13283protein_codingtolerated(0.28)benign(0.003)TCGA-AA-3864-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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