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Gene: G3BP1 |
Gene summary for G3BP1 |
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Gene information | Species | Human | Gene symbol | G3BP1 | Gene ID | 10146 |
Gene name | G3BP stress granule assembly factor 1 | |
Gene Alias | G3BP | |
Cytomap | 5q33.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q13283 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10146 | G3BP1 | P37T-E | Human | Esophagus | ESCC | 1.90e-19 | 7.39e-01 | 0.1371 |
10146 | G3BP1 | P38T-E | Human | Esophagus | ESCC | 2.86e-04 | 4.19e-01 | 0.127 |
10146 | G3BP1 | P39T-E | Human | Esophagus | ESCC | 5.14e-08 | 2.87e-01 | 0.0894 |
10146 | G3BP1 | P40T-E | Human | Esophagus | ESCC | 1.89e-07 | 5.08e-01 | 0.109 |
10146 | G3BP1 | P42T-E | Human | Esophagus | ESCC | 8.91e-27 | 9.10e-01 | 0.1175 |
10146 | G3BP1 | P44T-E | Human | Esophagus | ESCC | 2.59e-09 | 4.53e-01 | 0.1096 |
10146 | G3BP1 | P47T-E | Human | Esophagus | ESCC | 7.89e-17 | 3.84e-01 | 0.1067 |
10146 | G3BP1 | P48T-E | Human | Esophagus | ESCC | 1.73e-23 | 5.38e-01 | 0.0959 |
10146 | G3BP1 | P49T-E | Human | Esophagus | ESCC | 3.86e-12 | 1.93e+00 | 0.1768 |
10146 | G3BP1 | P52T-E | Human | Esophagus | ESCC | 1.89e-27 | 9.68e-01 | 0.1555 |
10146 | G3BP1 | P54T-E | Human | Esophagus | ESCC | 8.74e-28 | 1.01e+00 | 0.0975 |
10146 | G3BP1 | P56T-E | Human | Esophagus | ESCC | 9.11e-12 | 1.68e+00 | 0.1613 |
10146 | G3BP1 | P57T-E | Human | Esophagus | ESCC | 9.47e-15 | 4.01e-01 | 0.0926 |
10146 | G3BP1 | P61T-E | Human | Esophagus | ESCC | 3.62e-08 | 4.61e-01 | 0.099 |
10146 | G3BP1 | P62T-E | Human | Esophagus | ESCC | 6.92e-71 | 1.56e+00 | 0.1302 |
10146 | G3BP1 | P65T-E | Human | Esophagus | ESCC | 3.11e-21 | 3.60e-01 | 0.0978 |
10146 | G3BP1 | P74T-E | Human | Esophagus | ESCC | 2.31e-33 | 1.46e+00 | 0.1479 |
10146 | G3BP1 | P75T-E | Human | Esophagus | ESCC | 8.11e-29 | 8.06e-01 | 0.1125 |
10146 | G3BP1 | P76T-E | Human | Esophagus | ESCC | 2.29e-29 | 8.16e-01 | 0.1207 |
10146 | G3BP1 | P79T-E | Human | Esophagus | ESCC | 5.17e-40 | 9.06e-01 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030111 | Colorectum | AD | regulation of Wnt signaling pathway | 102/3918 | 328/18723 | 8.51e-06 | 2.03e-04 | 102 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0060070 | Colorectum | AD | canonical Wnt signaling pathway | 90/3918 | 303/18723 | 1.76e-04 | 2.38e-03 | 90 |
GO:0060828 | Colorectum | AD | regulation of canonical Wnt signaling pathway | 77/3918 | 253/18723 | 2.19e-04 | 2.87e-03 | 77 |
GO:0032481 | Colorectum | AD | positive regulation of type I interferon production | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:00600702 | Colorectum | MSS | canonical Wnt signaling pathway | 86/3467 | 303/18723 | 1.58e-05 | 3.56e-04 | 86 |
GO:00608282 | Colorectum | MSS | regulation of canonical Wnt signaling pathway | 74/3467 | 253/18723 | 1.99e-05 | 4.26e-04 | 74 |
GO:00072651 | Colorectum | MSS | Ras protein signal transduction | 91/3467 | 337/18723 | 7.20e-05 | 1.21e-03 | 91 |
GO:0030178 | Colorectum | MSS | negative regulation of Wnt signaling pathway | 48/3467 | 170/18723 | 1.23e-03 | 1.18e-02 | 48 |
GO:00323921 | Colorectum | MSS | DNA geometric change | 29/3467 | 90/18723 | 1.26e-03 | 1.20e-02 | 29 |
GO:00324811 | Colorectum | MSS | positive regulation of type I interferon production | 20/3467 | 58/18723 | 2.82e-03 | 2.20e-02 | 20 |
GO:0032508 | Colorectum | MSS | DNA duplex unwinding | 25/3467 | 84/18723 | 8.27e-03 | 4.99e-02 | 25 |
GO:00160553 | Colorectum | FAP | Wnt signaling pathway | 104/2622 | 444/18723 | 4.92e-08 | 3.92e-06 | 104 |
GO:01987383 | Colorectum | FAP | cell-cell signaling by wnt | 104/2622 | 446/18723 | 6.26e-08 | 4.54e-06 | 104 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
G3BP1 | SNV | Missense_Mutation | c.865N>A | p.Glu289Lys | p.E289K | Q13283 | protein_coding | tolerated(0.06) | benign(0.007) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
G3BP1 | SNV | Missense_Mutation | c.1247N>A | p.Arg416Gln | p.R416Q | Q13283 | protein_coding | tolerated(0.06) | benign(0.058) | TCGA-BH-A0B3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
G3BP1 | SNV | Missense_Mutation | novel | c.460N>C | p.Glu154Gln | p.E154Q | Q13283 | protein_coding | deleterious(0.02) | probably_damaging(0.96) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
G3BP1 | SNV | Missense_Mutation | c.1391N>T | p.Pro464Leu | p.P464L | Q13283 | protein_coding | deleterious_low_confidence(0.01) | benign(0.051) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
G3BP1 | SNV | Missense_Mutation | c.775C>G | p.Leu259Val | p.L259V | Q13283 | protein_coding | tolerated(0.11) | possibly_damaging(0.883) | TCGA-E2-A159-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
G3BP1 | SNV | Missense_Mutation | c.901N>G | p.Gln301Glu | p.Q301E | Q13283 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-EW-A1PB-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
G3BP1 | SNV | Missense_Mutation | novel | c.649C>G | p.Pro217Ala | p.P217A | Q13283 | protein_coding | tolerated(0.45) | benign(0) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
G3BP1 | SNV | Missense_Mutation | novel | c.488N>A | p.Pro163His | p.P163H | Q13283 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
G3BP1 | SNV | Missense_Mutation | c.344C>T | p.Ala115Val | p.A115V | Q13283 | protein_coding | tolerated(0.08) | benign(0.232) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
G3BP1 | SNV | Missense_Mutation | c.1280G>A | p.Arg427His | p.R427H | Q13283 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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