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Gene: FDFT1 |
Gene summary for FDFT1 |
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Gene information | Species | Human | Gene symbol | FDFT1 | Gene ID | 2222 |
Gene name | farnesyl-diphosphate farnesyltransferase 1 | |
Gene Alias | DGPT | |
Cytomap | 8p23.1 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | P37268 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2222 | FDFT1 | P23T-E | Human | Esophagus | ESCC | 3.85e-41 | 1.72e+00 | 0.108 |
2222 | FDFT1 | P24T-E | Human | Esophagus | ESCC | 8.23e-26 | 9.15e-01 | 0.1287 |
2222 | FDFT1 | P26T-E | Human | Esophagus | ESCC | 6.30e-25 | 7.61e-01 | 0.1276 |
2222 | FDFT1 | P27T-E | Human | Esophagus | ESCC | 1.13e-32 | 9.43e-01 | 0.1055 |
2222 | FDFT1 | P28T-E | Human | Esophagus | ESCC | 2.30e-63 | 1.83e+00 | 0.1149 |
2222 | FDFT1 | P30T-E | Human | Esophagus | ESCC | 3.36e-40 | 2.40e+00 | 0.137 |
2222 | FDFT1 | P31T-E | Human | Esophagus | ESCC | 2.12e-29 | 8.07e-01 | 0.1251 |
2222 | FDFT1 | P32T-E | Human | Esophagus | ESCC | 1.59e-46 | 1.37e+00 | 0.1666 |
2222 | FDFT1 | P36T-E | Human | Esophagus | ESCC | 7.86e-22 | 1.17e+00 | 0.1187 |
2222 | FDFT1 | P37T-E | Human | Esophagus | ESCC | 1.21e-15 | 6.50e-01 | 0.1371 |
2222 | FDFT1 | P38T-E | Human | Esophagus | ESCC | 1.51e-03 | 5.29e-01 | 0.127 |
2222 | FDFT1 | P39T-E | Human | Esophagus | ESCC | 6.29e-21 | 5.03e-01 | 0.0894 |
2222 | FDFT1 | P40T-E | Human | Esophagus | ESCC | 3.89e-12 | 6.43e-01 | 0.109 |
2222 | FDFT1 | P42T-E | Human | Esophagus | ESCC | 1.34e-29 | 1.51e+00 | 0.1175 |
2222 | FDFT1 | P44T-E | Human | Esophagus | ESCC | 2.29e-07 | 3.51e-01 | 0.1096 |
2222 | FDFT1 | P47T-E | Human | Esophagus | ESCC | 5.33e-31 | 1.05e+00 | 0.1067 |
2222 | FDFT1 | P48T-E | Human | Esophagus | ESCC | 5.87e-37 | 9.95e-01 | 0.0959 |
2222 | FDFT1 | P49T-E | Human | Esophagus | ESCC | 2.52e-04 | 9.72e-01 | 0.1768 |
2222 | FDFT1 | P52T-E | Human | Esophagus | ESCC | 2.76e-12 | 6.57e-01 | 0.1555 |
2222 | FDFT1 | P54T-E | Human | Esophagus | ESCC | 1.02e-29 | 9.67e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00060661 | Colorectum | SER | alcohol metabolic process | 79/2897 | 353/18723 | 3.50e-04 | 5.50e-03 | 79 |
GO:00066441 | Colorectum | SER | phospholipid metabolic process | 79/2897 | 383/18723 | 3.94e-03 | 3.24e-02 | 79 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:00060663 | Colorectum | FAP | alcohol metabolic process | 69/2622 | 353/18723 | 2.29e-03 | 1.85e-02 | 69 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
GO:00060664 | Colorectum | CRC | alcohol metabolic process | 57/2078 | 353/18723 | 2.37e-03 | 2.27e-02 | 57 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:00161263 | Esophagus | ESCC | sterol biosynthetic process | 46/8552 | 64/18723 | 1.91e-05 | 1.67e-04 | 46 |
GO:00066953 | Esophagus | ESCC | cholesterol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
GO:19026533 | Esophagus | ESCC | secondary alcohol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
GO:19026524 | Esophagus | ESCC | secondary alcohol metabolic process | 87/8552 | 147/18723 | 6.58e-04 | 3.50e-03 | 87 |
GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:00082034 | Esophagus | ESCC | cholesterol metabolic process | 79/8552 | 137/18723 | 3.11e-03 | 1.29e-02 | 79 |
GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa001005 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
hsa0010012 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
hsa00100 | Liver | Cirrhotic | Steroid biosynthesis | 12/2530 | 20/8465 | 4.92e-03 | 1.76e-02 | 1.09e-02 | 12 |
hsa001001 | Liver | Cirrhotic | Steroid biosynthesis | 12/2530 | 20/8465 | 4.92e-03 | 1.76e-02 | 1.09e-02 | 12 |
hsa001002 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
hsa001003 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
hsa001004 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
hsa0010011 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
hsa0010021 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
hsa0010031 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FDFT1 | SNV | Missense_Mutation | rs766941596 | c.203C>T | p.Ala68Val | p.A68V | P37268 | protein_coding | tolerated(0.06) | possibly_damaging(0.879) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
FDFT1 | SNV | Missense_Mutation | rs556051417 | c.380N>T | p.Thr127Met | p.T127M | P37268 | protein_coding | tolerated(0.21) | probably_damaging(0.99) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
FDFT1 | deletion | Frame_Shift_Del | c.418_421delNNNN | p.Thr141Ter | p.T141* | P37268 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
FDFT1 | insertion | Frame_Shift_Ins | novel | c.1125_1126insAGGGAGGA | p.Leu376ArgfsTer4 | p.L376Rfs*4 | P37268 | protein_coding | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
FDFT1 | insertion | Frame_Shift_Ins | novel | c.1126_1127insTCCAGGG | p.Ile377GlnfsTer78 | p.I377Qfs*78 | P37268 | protein_coding | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
FDFT1 | insertion | Frame_Shift_Ins | novel | c.361_362insCTTTTCTATT | p.Val121AlafsTer14 | p.V121Afs*14 | P37268 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
FDFT1 | SNV | Missense_Mutation | rs779354465 | c.1136G>A | p.Arg379Gln | p.R379Q | P37268 | protein_coding | tolerated(0.05) | benign(0.023) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
FDFT1 | SNV | Missense_Mutation | c.1043N>C | p.Arg348Thr | p.R348T | P37268 | protein_coding | deleterious(0.02) | benign(0.015) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FDFT1 | SNV | Missense_Mutation | rs139230476 | c.521N>G | p.Tyr174Cys | p.Y174C | P37268 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
FDFT1 | SNV | Missense_Mutation | rs755672538 | c.1103C>T | p.Thr368Met | p.T368M | P37268 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL435224 | LAPAQUISTAT ACETATE | |
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649794 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649735 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649656 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 223365913 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649715 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649789 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649665 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135649788 | ||
2222 | FDFT1 | DRUGGABLE GENOME, ENZYME | inhibitor | 135650240 |
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