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Gene: FBLIM1 |
Gene summary for FBLIM1 |
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Gene information | Species | Human | Gene symbol | FBLIM1 | Gene ID | 54751 |
Gene name | filamin binding LIM protein 1 | |
Gene Alias | CAL | |
Cytomap | 1p36.21 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8WUP2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54751 | FBLIM1 | P26T-E | Human | Esophagus | ESCC | 3.78e-25 | 4.64e-01 | 0.1276 |
54751 | FBLIM1 | P27T-E | Human | Esophagus | ESCC | 1.53e-21 | 4.14e-01 | 0.1055 |
54751 | FBLIM1 | P28T-E | Human | Esophagus | ESCC | 2.79e-16 | 3.25e-01 | 0.1149 |
54751 | FBLIM1 | P30T-E | Human | Esophagus | ESCC | 4.17e-11 | 5.99e-01 | 0.137 |
54751 | FBLIM1 | P31T-E | Human | Esophagus | ESCC | 1.70e-21 | 4.00e-01 | 0.1251 |
54751 | FBLIM1 | P32T-E | Human | Esophagus | ESCC | 4.35e-26 | 5.39e-01 | 0.1666 |
54751 | FBLIM1 | P36T-E | Human | Esophagus | ESCC | 2.97e-13 | 7.70e-01 | 0.1187 |
54751 | FBLIM1 | P37T-E | Human | Esophagus | ESCC | 7.52e-32 | 8.11e-01 | 0.1371 |
54751 | FBLIM1 | P38T-E | Human | Esophagus | ESCC | 2.78e-16 | 8.31e-01 | 0.127 |
54751 | FBLIM1 | P39T-E | Human | Esophagus | ESCC | 3.52e-16 | -2.50e-02 | 0.0894 |
54751 | FBLIM1 | P40T-E | Human | Esophagus | ESCC | 7.98e-13 | 4.97e-01 | 0.109 |
54751 | FBLIM1 | P42T-E | Human | Esophagus | ESCC | 3.98e-26 | 8.90e-01 | 0.1175 |
54751 | FBLIM1 | P44T-E | Human | Esophagus | ESCC | 1.77e-03 | 3.69e-01 | 0.1096 |
54751 | FBLIM1 | P47T-E | Human | Esophagus | ESCC | 1.09e-25 | 4.80e-01 | 0.1067 |
54751 | FBLIM1 | P48T-E | Human | Esophagus | ESCC | 1.81e-20 | 4.12e-01 | 0.0959 |
54751 | FBLIM1 | P49T-E | Human | Esophagus | ESCC | 1.65e-16 | 1.71e+00 | 0.1768 |
54751 | FBLIM1 | P52T-E | Human | Esophagus | ESCC | 1.27e-32 | 7.61e-01 | 0.1555 |
54751 | FBLIM1 | P54T-E | Human | Esophagus | ESCC | 2.87e-13 | 4.03e-01 | 0.0975 |
54751 | FBLIM1 | P56T-E | Human | Esophagus | ESCC | 1.22e-05 | 1.11e+00 | 0.1613 |
54751 | FBLIM1 | P57T-E | Human | Esophagus | ESCC | 1.25e-10 | 2.22e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0008360 | Colorectum | AD | regulation of cell shape | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:00226041 | Colorectum | SER | regulation of cell morphogenesis | 89/2897 | 309/18723 | 1.51e-09 | 1.52e-07 | 89 |
GO:00083601 | Colorectum | SER | regulation of cell shape | 43/2897 | 154/18723 | 5.47e-05 | 1.30e-03 | 43 |
GO:00226044 | Colorectum | FAP | regulation of cell morphogenesis | 87/2622 | 309/18723 | 4.89e-11 | 1.87e-08 | 87 |
GO:00432544 | Colorectum | FAP | regulation of protein-containing complex assembly | 101/2622 | 428/18723 | 5.18e-08 | 4.07e-06 | 101 |
GO:00083603 | Colorectum | FAP | regulation of cell shape | 43/2622 | 154/18723 | 4.55e-06 | 1.52e-04 | 43 |
GO:00226045 | Colorectum | CRC | regulation of cell morphogenesis | 74/2078 | 309/18723 | 9.25e-11 | 5.04e-08 | 74 |
GO:00432545 | Colorectum | CRC | regulation of protein-containing complex assembly | 87/2078 | 428/18723 | 1.38e-08 | 2.67e-06 | 87 |
GO:00083604 | Colorectum | CRC | regulation of cell shape | 38/2078 | 154/18723 | 1.51e-06 | 8.15e-05 | 38 |
GO:0043254111 | Esophagus | ESCC | regulation of protein-containing complex assembly | 278/8552 | 428/18723 | 3.81e-16 | 2.77e-14 | 278 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:000836018 | Esophagus | ESCC | regulation of cell shape | 92/8552 | 154/18723 | 3.00e-04 | 1.81e-03 | 92 |
GO:004325412 | Liver | Cirrhotic | regulation of protein-containing complex assembly | 169/4634 | 428/18723 | 7.40e-12 | 4.99e-10 | 169 |
GO:002260412 | Liver | Cirrhotic | regulation of cell morphogenesis | 127/4634 | 309/18723 | 1.45e-10 | 7.44e-09 | 127 |
GO:000836012 | Liver | Cirrhotic | regulation of cell shape | 69/4634 | 154/18723 | 4.21e-08 | 1.36e-06 | 69 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBLIM1 | SNV | Missense_Mutation | c.145N>G | p.Met49Val | p.M49V | Q8WUP2 | protein_coding | tolerated(0.31) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FBLIM1 | SNV | Missense_Mutation | c.992C>G | p.Ser331Cys | p.S331C | Q8WUP2 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.924) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBLIM1 | SNV | Missense_Mutation | rs145692215 | c.32C>T | p.Ser11Leu | p.S11L | Q8WUP2 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | c.962G>T | p.Ser321Ile | p.S321I | Q8WUP2 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
FBLIM1 | SNV | Missense_Mutation | c.722N>A | p.Cys241Tyr | p.C241Y | Q8WUP2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FBLIM1 | insertion | Frame_Shift_Ins | novel | c.1094_1095insCT | p.Arg366Ter | p.R366* | Q8WUP2 | protein_coding | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
FBLIM1 | SNV | Missense_Mutation | novel | c.817N>A | p.Ala273Thr | p.A273T | Q8WUP2 | protein_coding | deleterious(0.03) | possibly_damaging(0.844) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | rs750253844 | c.112C>T | p.Arg38Trp | p.R38W | Q8WUP2 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | novel | c.727N>G | p.Ile243Val | p.I243V | Q8WUP2 | protein_coding | tolerated(1) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBLIM1 | SNV | Missense_Mutation | novel | c.158N>G | p.Glu53Gly | p.E53G | Q8WUP2 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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