![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FAU |
Gene summary for FAU |
![]() |
Gene information | Species | Human | Gene symbol | FAU | Gene ID | 2197 |
Gene name | FAU ubiquitin like and ribosomal protein S30 fusion | |
Gene Alias | FAU1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P35544 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2197 | FAU | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.27e-20 | 1.75e+00 | 0.0131 |
2197 | FAU | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.22e-31 | 1.72e+00 | -0.0177 |
2197 | FAU | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.79e-20 | 1.83e+00 | 0.0171 |
2197 | FAU | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.69e-51 | 1.86e+00 | 0.0338 |
2197 | FAU | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.14e-75 | 1.67e+00 | 0.0674 |
2197 | FAU | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.58e-25 | 1.62e+00 | 0.0112 |
2197 | FAU | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.55e-20 | 1.99e+00 | -0.0124 |
2197 | FAU | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.24e-14 | 1.52e+00 | 0.0397 |
2197 | FAU | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.78e-39 | 1.70e+00 | 0.0588 |
2197 | FAU | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.75e-57 | 1.52e+00 | 0.294 |
2197 | FAU | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.25e-15 | 2.59e+00 | 0.3487 |
2197 | FAU | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.16e-30 | 1.45e+00 | 0.281 |
2197 | FAU | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.44e-92 | 2.42e+00 | 0.3859 |
2197 | FAU | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.82e-34 | 1.80e+00 | 0.2585 |
2197 | FAU | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.37e-87 | 1.98e+00 | 0.3005 |
2197 | FAU | A014-C-108 | Human | Colorectum | FAP | 1.58e-02 | -1.45e-01 | -0.124 |
2197 | FAU | A015-C-104 | Human | Colorectum | FAP | 2.98e-02 | -1.33e-01 | -0.1899 |
2197 | FAU | F034 | Human | Colorectum | FAP | 1.53e-02 | -1.35e-01 | -0.0665 |
2197 | FAU | AEH-subject1 | Human | Endometrium | AEH | 1.55e-58 | -6.03e-01 | -0.3059 |
2197 | FAU | AEH-subject2 | Human | Endometrium | AEH | 1.17e-37 | -6.21e-01 | -0.2525 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa051712 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
hsa051713 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
Page: 1 2 3 4 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAU | SNV | Missense_Mutation | c.271N>T | p.Pro91Ser | p.P91S | P62861,P35544 | protein_coding | deleterious(0.02) | benign(0.134) | TCGA-BH-A0B0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
FAU | insertion | Frame_Shift_Ins | novel | c.125_126insG | p.Leu43ProfsTer9 | p.L43Pfs*9 | P62861,P35544 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAU | insertion | Frame_Shift_Ins | novel | c.123_124insTTGGGAGCATGGCCTCGTTTGTACCTCTGTGA | p.Leu43GlyfsTer31 | p.L43Gfs*31 | P62861,P35544 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FAU | deletion | Frame_Shift_Del | novel | c.22delC | p.Gln8ArgfsTer8 | p.Q8Rfs*8 | P62861,P35544 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FAU | SNV | Missense_Mutation | rs767227130 | c.322N>T | p.Arg108Trp | p.R108W | P62861,P35544 | protein_coding | tolerated(0.11) | benign(0.048) | TCGA-AA-3968-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAU | SNV | Missense_Mutation | c.391N>A | p.Ala131Thr | p.A131T | P62861,P35544 | protein_coding | deleterious(0.04) | probably_damaging(0.949) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
FAU | SNV | Missense_Mutation | rs372080439 | c.325C>T | p.Arg109Trp | p.R109W | P62861,P35544 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AF-3400-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
FAU | SNV | Missense_Mutation | c.335N>G | p.Tyr112Cys | p.Y112C | P62861,P35544 | protein_coding | deleterious(0) | possibly_damaging(0.86) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAU | SNV | Missense_Mutation | novel | c.232N>T | p.Gly78Cys | p.G78C | P62861,P35544 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
FAU | SNV | Missense_Mutation | novel | c.232N>T | p.Gly78Cys | p.G78C | P62861,P35544 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |