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Gene: ETV5 |
Gene summary for ETV5 |
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Gene information | Species | Human | Gene symbol | ETV5 | Gene ID | 2119 |
Gene name | ETS variant transcription factor 5 | |
Gene Alias | ERM | |
Cytomap | 3q27.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P41161 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2119 | ETV5 | C21 | Human | Oral cavity | OSCC | 5.76e-05 | 2.67e-01 | 0.2678 |
2119 | ETV5 | C30 | Human | Oral cavity | OSCC | 3.92e-10 | 5.13e-01 | 0.3055 |
2119 | ETV5 | C43 | Human | Oral cavity | OSCC | 1.58e-10 | 1.97e-01 | 0.1704 |
2119 | ETV5 | C06 | Human | Oral cavity | OSCC | 1.31e-09 | 7.19e-01 | 0.2699 |
2119 | ETV5 | C08 | Human | Oral cavity | OSCC | 9.80e-18 | 4.09e-01 | 0.1919 |
2119 | ETV5 | C09 | Human | Oral cavity | OSCC | 6.56e-11 | 4.08e-01 | 0.1431 |
2119 | ETV5 | LN38 | Human | Oral cavity | OSCC | 4.33e-03 | 8.69e-01 | 0.168 |
2119 | ETV5 | LP15 | Human | Oral cavity | LP | 2.65e-04 | 8.24e-01 | 0.2174 |
2119 | ETV5 | LP17 | Human | Oral cavity | LP | 2.12e-09 | 7.34e-01 | 0.2349 |
2119 | ETV5 | SYSMH2 | Human | Oral cavity | OSCC | 9.56e-03 | 7.46e-02 | 0.2326 |
2119 | ETV5 | male-WTA | Human | Thyroid | PTC | 3.79e-26 | 2.68e-01 | 0.1037 |
2119 | ETV5 | PTC01 | Human | Thyroid | PTC | 7.54e-13 | 2.72e-01 | 0.1899 |
2119 | ETV5 | PTC03 | Human | Thyroid | PTC | 2.12e-04 | 1.42e-01 | 0.1784 |
2119 | ETV5 | PTC04 | Human | Thyroid | PTC | 1.56e-13 | 3.53e-01 | 0.1927 |
2119 | ETV5 | PTC05 | Human | Thyroid | PTC | 1.36e-16 | 5.54e-01 | 0.2065 |
2119 | ETV5 | PTC06 | Human | Thyroid | PTC | 4.06e-22 | 5.67e-01 | 0.2057 |
2119 | ETV5 | PTC07 | Human | Thyroid | PTC | 1.16e-24 | 3.45e-01 | 0.2044 |
2119 | ETV5 | ATC11 | Human | Thyroid | ATC | 4.19e-02 | 2.58e-01 | 0.3386 |
2119 | ETV5 | ATC12 | Human | Thyroid | ATC | 2.91e-04 | 7.23e-02 | 0.34 |
2119 | ETV5 | ATC2 | Human | Thyroid | ATC | 1.01e-07 | 5.27e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00140091 | Esophagus | ESCC | glial cell proliferation | 37/8552 | 51/18723 | 9.01e-05 | 6.50e-04 | 37 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:00602511 | Esophagus | ESCC | regulation of glial cell proliferation | 25/8552 | 36/18723 | 3.39e-03 | 1.39e-02 | 25 |
GO:00140151 | Esophagus | ESCC | positive regulation of gliogenesis | 41/8552 | 66/18723 | 5.22e-03 | 1.97e-02 | 41 |
GO:00602521 | Esophagus | ESCC | positive regulation of glial cell proliferation | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:00140131 | Esophagus | ESCC | regulation of gliogenesis | 59/8552 | 103/18723 | 1.17e-02 | 3.91e-02 | 59 |
GO:0008356 | Esophagus | ESCC | asymmetric cell division | 14/8552 | 19/18723 | 1.27e-02 | 4.21e-02 | 14 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
GO:001072011 | Liver | HCC | positive regulation of cell development | 155/7958 | 298/18723 | 5.39e-04 | 3.48e-03 | 155 |
GO:00507674 | Liver | HCC | regulation of neurogenesis | 181/7958 | 364/18723 | 3.00e-03 | 1.40e-02 | 181 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0521516 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0521517 | Esophagus | ESCC | Prostate cancer | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0521510 | Oral cavity | OSCC | Prostate cancer | 66/3704 | 97/8465 | 1.05e-06 | 5.89e-06 | 3.00e-06 | 66 |
hsa0521515 | Oral cavity | OSCC | Prostate cancer | 66/3704 | 97/8465 | 1.05e-06 | 5.89e-06 | 3.00e-06 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ETV5 | SNV | Missense_Mutation | c.819T>A | p.His273Gln | p.H273Q | P41161 | protein_coding | tolerated(1) | benign(0.007) | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |
ETV5 | SNV | Missense_Mutation | rs763950262 | c.766N>T | p.Pro256Ser | p.P256S | P41161 | protein_coding | tolerated(0.07) | benign(0.225) | TCGA-AR-A24L-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | PD |
ETV5 | SNV | Missense_Mutation | novel | c.1291G>A | p.Glu431Lys | p.E431K | P41161 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
ETV5 | SNV | Missense_Mutation | c.16N>C | p.Asp6His | p.D6H | P41161 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ETV5 | SNV | Missense_Mutation | rs777358489 | c.1175N>A | p.Arg392Gln | p.R392Q | P41161 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E9-A1NA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ETV5 | SNV | Missense_Mutation | rs201874364 | c.901G>A | p.Val301Ile | p.V301I | P41161 | protein_coding | tolerated(0.27) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ETV5 | SNV | Missense_Mutation | c.313N>A | p.Glu105Lys | p.E105K | P41161 | protein_coding | tolerated(0.73) | possibly_damaging(0.562) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ETV5 | SNV | Missense_Mutation | c.1207N>A | p.Glu403Lys | p.E403K | P41161 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EK-A2R7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ETV5 | SNV | Missense_Mutation | novel | c.1415N>G | p.Glu472Gly | p.E472G | P41161 | protein_coding | deleterious(0) | benign(0.015) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ETV5 | SNV | Missense_Mutation | c.1514C>T | p.Ala505Val | p.A505V | P41161 | protein_coding | tolerated(0.11) | benign(0.017) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2119 | ETV5 | DRUG RESISTANCE, CLINICALLY ACTIONABLE | TRAMETINIB | TRAMETINIB | 28178529 |
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