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Gene: EIF1AD |
Gene summary for EIF1AD |
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Gene information | Species | Human | Gene symbol | EIF1AD | Gene ID | 84285 |
Gene name | eukaryotic translation initiation factor 1A domain containing | |
Gene Alias | OBELIX | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024R5B9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84285 | EIF1AD | C43 | Human | Oral cavity | OSCC | 3.49e-21 | 3.84e-01 | 0.1704 |
84285 | EIF1AD | C51 | Human | Oral cavity | OSCC | 1.75e-09 | 5.32e-01 | 0.2674 |
84285 | EIF1AD | C57 | Human | Oral cavity | OSCC | 2.95e-15 | 4.62e-01 | 0.1679 |
84285 | EIF1AD | C08 | Human | Oral cavity | OSCC | 2.78e-13 | 3.03e-01 | 0.1919 |
84285 | EIF1AD | C09 | Human | Oral cavity | OSCC | 1.03e-04 | 1.59e-01 | 0.1431 |
84285 | EIF1AD | LN22 | Human | Oral cavity | OSCC | 5.62e-03 | 5.32e-01 | 0.1733 |
84285 | EIF1AD | LN46 | Human | Oral cavity | OSCC | 9.01e-03 | 2.01e-01 | 0.1666 |
84285 | EIF1AD | LP15 | Human | Oral cavity | LP | 2.22e-03 | 6.84e-01 | 0.2174 |
84285 | EIF1AD | SYSMH1 | Human | Oral cavity | OSCC | 3.50e-08 | 2.35e-01 | 0.1127 |
84285 | EIF1AD | SYSMH2 | Human | Oral cavity | OSCC | 2.31e-11 | 3.28e-01 | 0.2326 |
84285 | EIF1AD | SYSMH3 | Human | Oral cavity | OSCC | 7.20e-10 | 2.73e-01 | 0.2442 |
84285 | EIF1AD | SYSMH5 | Human | Oral cavity | OSCC | 1.51e-04 | 1.34e-01 | 0.0647 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:000641318 | Oral cavity | OSCC | translational initiation | 96/7305 | 118/18723 | 4.02e-21 | 7.06e-19 | 96 |
GO:000641319 | Oral cavity | LP | translational initiation | 75/4623 | 118/18723 | 3.96e-19 | 7.52e-17 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF1AD | SNV | Missense_Mutation | c.13A>G | p.Thr5Ala | p.T5A | Q8N9N8 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EIF1AD | SNV | Missense_Mutation | rs763730593 | c.143N>A | p.Arg48His | p.R48H | Q8N9N8 | protein_coding | tolerated(0.09) | benign(0.018) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
EIF1AD | SNV | Missense_Mutation | novel | c.49G>A | p.Glu17Lys | p.E17K | Q8N9N8 | protein_coding | deleterious(0.04) | benign(0.412) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
EIF1AD | SNV | Missense_Mutation | rs201148001 | c.281N>A | p.Arg94His | p.R94H | Q8N9N8 | protein_coding | tolerated(0.05) | possibly_damaging(0.649) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF1AD | SNV | Missense_Mutation | rs377762380 | c.280N>T | p.Arg94Cys | p.R94C | Q8N9N8 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
EIF1AD | SNV | Missense_Mutation | novel | c.387N>T | p.Gln129His | p.Q129H | Q8N9N8 | protein_coding | tolerated(0.24) | benign(0) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
EIF1AD | SNV | Missense_Mutation | novel | c.421N>G | p.Ser141Ala | p.S141A | Q8N9N8 | protein_coding | tolerated(0.2) | benign(0.344) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF1AD | SNV | Missense_Mutation | c.452N>T | p.Gln151Leu | p.Q151L | Q8N9N8 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
EIF1AD | SNV | Missense_Mutation | c.305G>T | p.Trp102Leu | p.W102L | Q8N9N8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD | |
EIF1AD | SNV | Missense_Mutation | novel | c.455N>G | p.Tyr152Cys | p.Y152C | Q8N9N8 | protein_coding | deleterious(0.01) | benign(0) | TCGA-68-8250-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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