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Gene: EEA1 |
Gene summary for EEA1 |
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Gene information | Species | Human | Gene symbol | EEA1 | Gene ID | 8411 |
Gene name | early endosome antigen 1 | |
Gene Alias | MST105 | |
Cytomap | 12q22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q15075 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8411 | EEA1 | P19T-E | Human | Esophagus | ESCC | 4.50e-18 | 1.10e+00 | 0.1662 |
8411 | EEA1 | P20T-E | Human | Esophagus | ESCC | 8.71e-29 | 7.03e-01 | 0.1124 |
8411 | EEA1 | P21T-E | Human | Esophagus | ESCC | 5.19e-47 | 8.97e-01 | 0.1617 |
8411 | EEA1 | P22T-E | Human | Esophagus | ESCC | 6.70e-20 | 4.79e-01 | 0.1236 |
8411 | EEA1 | P23T-E | Human | Esophagus | ESCC | 3.94e-33 | 1.08e+00 | 0.108 |
8411 | EEA1 | P24T-E | Human | Esophagus | ESCC | 2.55e-24 | 5.86e-01 | 0.1287 |
8411 | EEA1 | P26T-E | Human | Esophagus | ESCC | 3.04e-36 | 6.65e-01 | 0.1276 |
8411 | EEA1 | P27T-E | Human | Esophagus | ESCC | 1.50e-43 | 8.91e-01 | 0.1055 |
8411 | EEA1 | P28T-E | Human | Esophagus | ESCC | 3.31e-26 | 5.29e-01 | 0.1149 |
8411 | EEA1 | P30T-E | Human | Esophagus | ESCC | 5.81e-30 | 1.17e+00 | 0.137 |
8411 | EEA1 | P31T-E | Human | Esophagus | ESCC | 1.30e-11 | 2.95e-01 | 0.1251 |
8411 | EEA1 | P32T-E | Human | Esophagus | ESCC | 9.10e-28 | 5.75e-01 | 0.1666 |
8411 | EEA1 | P36T-E | Human | Esophagus | ESCC | 9.34e-30 | 8.32e-01 | 0.1187 |
8411 | EEA1 | P37T-E | Human | Esophagus | ESCC | 1.26e-17 | 4.87e-01 | 0.1371 |
8411 | EEA1 | P38T-E | Human | Esophagus | ESCC | 1.43e-08 | 3.91e-01 | 0.127 |
8411 | EEA1 | P39T-E | Human | Esophagus | ESCC | 2.12e-13 | 3.63e-01 | 0.0894 |
8411 | EEA1 | P40T-E | Human | Esophagus | ESCC | 5.20e-09 | 3.28e-01 | 0.109 |
8411 | EEA1 | P42T-E | Human | Esophagus | ESCC | 4.35e-32 | 8.53e-01 | 0.1175 |
8411 | EEA1 | P44T-E | Human | Esophagus | ESCC | 3.09e-27 | 7.93e-01 | 0.1096 |
8411 | EEA1 | P47T-E | Human | Esophagus | ESCC | 5.38e-14 | 3.10e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603210 | Cervix | CC | viral process | 109/2311 | 415/18723 | 5.40e-15 | 6.46e-12 | 109 |
GO:001905810 | Cervix | CC | viral life cycle | 87/2311 | 317/18723 | 2.20e-13 | 1.20e-10 | 87 |
GO:001907910 | Cervix | CC | viral genome replication | 35/2311 | 131/18723 | 6.11e-06 | 1.49e-04 | 35 |
GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
GO:00995322 | Cervix | CC | synaptic vesicle endosomal processing | 6/2311 | 10/18723 | 4.73e-04 | 4.68e-03 | 6 |
GO:00160506 | Cervix | CC | vesicle organization | 54/2311 | 300/18723 | 2.71e-03 | 1.85e-02 | 54 |
GO:00164827 | Cervix | CC | cytosolic transport | 33/2311 | 168/18723 | 4.43e-03 | 2.70e-02 | 33 |
GO:001603225 | Cervix | N_HPV | viral process | 33/534 | 415/18723 | 1.23e-07 | 1.15e-05 | 33 |
GO:001905825 | Cervix | N_HPV | viral life cycle | 23/534 | 317/18723 | 4.35e-05 | 1.03e-03 | 23 |
GO:001907924 | Cervix | N_HPV | viral genome replication | 10/534 | 131/18723 | 4.34e-03 | 3.30e-02 | 10 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0019079 | Colorectum | AD | viral genome replication | 51/3918 | 131/18723 | 1.83e-06 | 5.51e-05 | 51 |
GO:0007032 | Colorectum | AD | endosome organization | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0098927 | Colorectum | AD | vesicle-mediated transport between endosomal compartments | 19/3918 | 43/18723 | 5.03e-04 | 5.43e-03 | 19 |
GO:0045022 | Colorectum | AD | early endosome to late endosome transport | 17/3918 | 40/18723 | 1.66e-03 | 1.38e-02 | 17 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414520 | Cervix | CC | Phagosome | 47/1267 | 152/8465 | 3.95e-07 | 4.26e-06 | 2.52e-06 | 47 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa05152 | Cervix | CC | Tuberculosis | 42/1267 | 180/8465 | 1.78e-03 | 7.21e-03 | 4.26e-03 | 42 |
hsa04145110 | Cervix | CC | Phagosome | 47/1267 | 152/8465 | 3.95e-07 | 4.26e-06 | 2.52e-06 | 47 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa051521 | Cervix | CC | Tuberculosis | 42/1267 | 180/8465 | 1.78e-03 | 7.21e-03 | 4.26e-03 | 42 |
hsa0414542 | Cervix | N_HPV | Phagosome | 24/349 | 152/8465 | 1.17e-08 | 2.88e-07 | 2.25e-07 | 24 |
hsa051524 | Cervix | N_HPV | Tuberculosis | 16/349 | 180/8465 | 3.05e-03 | 1.73e-02 | 1.35e-02 | 16 |
hsa0414552 | Cervix | N_HPV | Phagosome | 24/349 | 152/8465 | 1.17e-08 | 2.88e-07 | 2.25e-07 | 24 |
hsa051525 | Cervix | N_HPV | Tuberculosis | 16/349 | 180/8465 | 3.05e-03 | 1.73e-02 | 1.35e-02 | 16 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EEA1 | SNV | Missense_Mutation | c.1153G>C | p.Glu385Gln | p.E385Q | Q15075 | protein_coding | deleterious(0.01) | possibly_damaging(0.666) | TCGA-A2-A04X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
EEA1 | SNV | Missense_Mutation | c.3172C>G | p.Leu1058Val | p.L1058V | Q15075 | protein_coding | tolerated(0.21) | probably_damaging(0.978) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
EEA1 | SNV | Missense_Mutation | novel | c.3706N>C | p.Glu1236Gln | p.E1236Q | Q15075 | protein_coding | deleterious(0) | benign(0.229) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
EEA1 | SNV | Missense_Mutation | c.3889N>C | p.Glu1297Gln | p.E1297Q | Q15075 | protein_coding | deleterious(0) | possibly_damaging(0.868) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EEA1 | SNV | Missense_Mutation | c.1252N>G | p.Gln418Glu | p.Q418E | Q15075 | protein_coding | deleterious(0.03) | probably_damaging(0.93) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
EEA1 | SNV | Missense_Mutation | rs748549413 | c.2176G>A | p.Glu726Lys | p.E726K | Q15075 | protein_coding | tolerated(0.13) | probably_damaging(0.981) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EEA1 | SNV | Missense_Mutation | c.1106A>G | p.Glu369Gly | p.E369G | Q15075 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EEA1 | SNV | Missense_Mutation | c.1820N>T | p.Ala607Val | p.A607V | Q15075 | protein_coding | tolerated(0.06) | probably_damaging(0.985) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EEA1 | SNV | Missense_Mutation | novel | c.661G>A | p.Glu221Lys | p.E221K | Q15075 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-E2-A573-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
EEA1 | SNV | Missense_Mutation | novel | c.3995N>A | p.Arg1332Lys | p.R1332K | Q15075 | protein_coding | deleterious(0) | possibly_damaging(0.811) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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