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Gene: DRAP1 |
Gene summary for DRAP1 |
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Gene information | Species | Human | Gene symbol | DRAP1 | Gene ID | 10589 |
Gene name | DR1 associated protein 1 | |
Gene Alias | NC2-alpha | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q14919 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10589 | DRAP1 | P10T-E | Human | Esophagus | ESCC | 1.28e-47 | 1.15e+00 | 0.116 |
10589 | DRAP1 | P11T-E | Human | Esophagus | ESCC | 4.02e-28 | 1.67e+00 | 0.1426 |
10589 | DRAP1 | P12T-E | Human | Esophagus | ESCC | 7.21e-73 | 1.43e+00 | 0.1122 |
10589 | DRAP1 | P15T-E | Human | Esophagus | ESCC | 6.17e-55 | 1.61e+00 | 0.1149 |
10589 | DRAP1 | P16T-E | Human | Esophagus | ESCC | 9.71e-65 | 1.35e+00 | 0.1153 |
10589 | DRAP1 | P17T-E | Human | Esophagus | ESCC | 3.66e-30 | 1.50e+00 | 0.1278 |
10589 | DRAP1 | P19T-E | Human | Esophagus | ESCC | 8.49e-17 | 1.74e+00 | 0.1662 |
10589 | DRAP1 | P20T-E | Human | Esophagus | ESCC | 2.44e-49 | 1.32e+00 | 0.1124 |
10589 | DRAP1 | P21T-E | Human | Esophagus | ESCC | 9.72e-81 | 2.17e+00 | 0.1617 |
10589 | DRAP1 | P22T-E | Human | Esophagus | ESCC | 1.31e-58 | 1.16e+00 | 0.1236 |
10589 | DRAP1 | P23T-E | Human | Esophagus | ESCC | 1.16e-51 | 1.55e+00 | 0.108 |
10589 | DRAP1 | P24T-E | Human | Esophagus | ESCC | 1.83e-69 | 1.54e+00 | 0.1287 |
10589 | DRAP1 | P26T-E | Human | Esophagus | ESCC | 4.02e-56 | 1.18e+00 | 0.1276 |
10589 | DRAP1 | P27T-E | Human | Esophagus | ESCC | 2.11e-43 | 9.88e-01 | 0.1055 |
10589 | DRAP1 | P28T-E | Human | Esophagus | ESCC | 5.74e-88 | 1.91e+00 | 0.1149 |
10589 | DRAP1 | P30T-E | Human | Esophagus | ESCC | 6.87e-47 | 2.18e+00 | 0.137 |
10589 | DRAP1 | P31T-E | Human | Esophagus | ESCC | 1.08e-69 | 1.65e+00 | 0.1251 |
10589 | DRAP1 | P32T-E | Human | Esophagus | ESCC | 2.50e-104 | 2.56e+00 | 0.1666 |
10589 | DRAP1 | P36T-E | Human | Esophagus | ESCC | 5.85e-32 | 1.57e+00 | 0.1187 |
10589 | DRAP1 | P37T-E | Human | Esophagus | ESCC | 1.07e-62 | 1.96e+00 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DRAP1 | SNV | Missense_Mutation | c.239T>A | p.Phe80Tyr | p.F80Y | Q14919 | protein_coding | deleterious(0.01) | possibly_damaging(0.804) | TCGA-OL-A66N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
DRAP1 | SNV | Missense_Mutation | c.326N>A | p.Arg109His | p.R109H | Q14919 | protein_coding | tolerated(0.11) | benign(0.027) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DRAP1 | SNV | Missense_Mutation | novel | c.8N>T | p.Ser3Ile | p.S3I | Q14919 | protein_coding | deleterious(0.03) | possibly_damaging(0.497) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
DRAP1 | SNV | Missense_Mutation | c.179N>A | p.Arg60Gln | p.R60Q | Q14919 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
DRAP1 | SNV | Missense_Mutation | rs781734189 | c.598G>A | p.Glu200Lys | p.E200K | Q14919 | protein_coding | deleterious_low_confidence(0.01) | benign(0.269) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DRAP1 | SNV | Missense_Mutation | rs143922438 | c.580G>A | p.Ala194Thr | p.A194T | Q14919 | protein_coding | tolerated_low_confidence(0.15) | benign(0.11) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DRAP1 | insertion | Frame_Shift_Ins | rs751570365 | c.513-1_513insC | p.Thr174AspfsTer23 | p.T174Dfs*23 | Q14919 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
DRAP1 | SNV | Missense_Mutation | c.266C>A | p.Ser89Tyr | p.S89Y | Q14919 | protein_coding | deleterious(0) | possibly_damaging(0.79) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
DRAP1 | SNV | Missense_Mutation | rs777331540 | c.538G>A | p.Ala180Thr | p.A180T | Q14919 | protein_coding | tolerated_low_confidence(0.65) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
DRAP1 | SNV | Missense_Mutation | rs777331540 | c.538G>A | p.Ala180Thr | p.A180T | Q14919 | protein_coding | tolerated_low_confidence(0.65) | benign(0) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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