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Gene: DOPEY2 |
Gene summary for DOPEY2 |
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Gene information | Species | Human | Gene symbol | DOPEY2 | Gene ID | 9980 |
Gene name | DOP1 leucine zipper like protein B | |
Gene Alias | 21orf5 | |
Cytomap | 21q22.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9Y3R5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9980 | DOPEY2 | P12T-E | Human | Esophagus | ESCC | 3.57e-09 | 1.04e-01 | 0.1122 |
9980 | DOPEY2 | P15T-E | Human | Esophagus | ESCC | 3.46e-03 | 4.45e-02 | 0.1149 |
9980 | DOPEY2 | P16T-E | Human | Esophagus | ESCC | 9.13e-05 | 4.84e-02 | 0.1153 |
9980 | DOPEY2 | P21T-E | Human | Esophagus | ESCC | 2.08e-08 | 7.45e-02 | 0.1617 |
9980 | DOPEY2 | P22T-E | Human | Esophagus | ESCC | 1.21e-11 | 7.86e-02 | 0.1236 |
9980 | DOPEY2 | P23T-E | Human | Esophagus | ESCC | 1.26e-07 | 1.78e-01 | 0.108 |
9980 | DOPEY2 | P24T-E | Human | Esophagus | ESCC | 4.70e-08 | 5.57e-02 | 0.1287 |
9980 | DOPEY2 | P26T-E | Human | Esophagus | ESCC | 2.12e-09 | 6.37e-02 | 0.1276 |
9980 | DOPEY2 | P27T-E | Human | Esophagus | ESCC | 2.81e-21 | 2.93e-01 | 0.1055 |
9980 | DOPEY2 | P28T-E | Human | Esophagus | ESCC | 9.17e-10 | 2.02e-01 | 0.1149 |
9980 | DOPEY2 | P31T-E | Human | Esophagus | ESCC | 7.74e-09 | 5.00e-02 | 0.1251 |
9980 | DOPEY2 | P32T-E | Human | Esophagus | ESCC | 3.12e-07 | 7.86e-02 | 0.1666 |
9980 | DOPEY2 | P37T-E | Human | Esophagus | ESCC | 3.33e-09 | 1.18e-01 | 0.1371 |
9980 | DOPEY2 | P39T-E | Human | Esophagus | ESCC | 7.94e-10 | 2.04e-01 | 0.0894 |
9980 | DOPEY2 | P40T-E | Human | Esophagus | ESCC | 1.09e-02 | 8.42e-02 | 0.109 |
9980 | DOPEY2 | P44T-E | Human | Esophagus | ESCC | 4.89e-07 | 1.54e-01 | 0.1096 |
9980 | DOPEY2 | P47T-E | Human | Esophagus | ESCC | 4.55e-06 | 1.33e-02 | 0.1067 |
9980 | DOPEY2 | P48T-E | Human | Esophagus | ESCC | 6.06e-05 | 5.96e-02 | 0.0959 |
9980 | DOPEY2 | P52T-E | Human | Esophagus | ESCC | 7.64e-11 | 9.84e-02 | 0.1555 |
9980 | DOPEY2 | P54T-E | Human | Esophagus | ESCC | 2.35e-09 | 2.25e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY2 | SNV | Missense_Mutation | novel | c.6487C>A | p.Pro2163Thr | p.P2163T | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.5416C>G | p.Leu1806Val | p.L1806V | Q9Y3R5 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | novel | c.4835N>G | p.Asn1612Ser | p.N1612S | Q9Y3R5 | protein_coding | tolerated(0.4) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DOPEY2 | SNV | Missense_Mutation | c.5017N>G | p.Leu1673Val | p.L1673V | Q9Y3R5 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.262N>C | p.Glu88Gln | p.E88Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | c.6664N>A | p.Glu2222Lys | p.E2222K | Q9Y3R5 | protein_coding | tolerated(0.57) | benign(0.033) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOPEY2 | SNV | Missense_Mutation | novel | c.404C>A | p.Pro135Gln | p.P135Q | Q9Y3R5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
DOPEY2 | insertion | Nonsense_Mutation | novel | c.6452_6453insCATTTGATAATACTTACTAGTTTTTTAT | p.Ala2152IlefsTer2 | p.A2152Ifs*2 | Q9Y3R5 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DOPEY2 | insertion | Nonsense_Mutation | novel | c.4966_4967insCGCAAATGCATATGCAAATGCATGTATATAATTAAC | p.Gly1656delinsAlaGlnMetHisMetGlnMetHisValTyrAsnTerArg | p.G1656delinsAQMHMQMHVYN*R | Q9Y3R5 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
DOPEY2 | insertion | In_Frame_Ins | novel | c.2865_2866insACTCTGGTTTGGGTGACAGAGCAAGACTCCGTCTCAAAAAATAAA | p.Arg955_Ser956insThrLeuValTrpValThrGluGlnAspSerValSerLysAsnLys | p.R955_S956insTLVWVTEQDSVSKNK | Q9Y3R5 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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