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Gene: DNAJC30 |
Gene summary for DNAJC30 |
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Gene information | Species | Human | Gene symbol | DNAJC30 | Gene ID | 84277 |
Gene name | DnaJ heat shock protein family (Hsp40) member C30 | |
Gene Alias | LHONAR | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | B3KSU4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84277 | DNAJC30 | HCC2_Meng | Human | Liver | HCC | 2.46e-11 | 1.37e-02 | 0.0107 |
84277 | DNAJC30 | cirrhotic1 | Human | Liver | Cirrhotic | 2.75e-05 | 1.55e-01 | 0.0202 |
84277 | DNAJC30 | cirrhotic2 | Human | Liver | Cirrhotic | 1.31e-03 | 9.45e-02 | 0.0201 |
84277 | DNAJC30 | HCC2 | Human | Liver | HCC | 1.79e-04 | 2.64e+00 | 0.5341 |
84277 | DNAJC30 | S014 | Human | Liver | HCC | 3.14e-14 | 6.73e-01 | 0.2254 |
84277 | DNAJC30 | S015 | Human | Liver | HCC | 3.03e-15 | 7.90e-01 | 0.2375 |
84277 | DNAJC30 | S016 | Human | Liver | HCC | 5.69e-17 | 6.39e-01 | 0.2243 |
84277 | DNAJC30 | S028 | Human | Liver | HCC | 2.69e-13 | 5.40e-01 | 0.2503 |
84277 | DNAJC30 | S029 | Human | Liver | HCC | 1.88e-11 | 7.69e-01 | 0.2581 |
84277 | DNAJC30 | C04 | Human | Oral cavity | OSCC | 6.67e-14 | 7.29e-01 | 0.2633 |
84277 | DNAJC30 | C21 | Human | Oral cavity | OSCC | 9.22e-19 | 6.57e-01 | 0.2678 |
84277 | DNAJC30 | C30 | Human | Oral cavity | OSCC | 5.34e-19 | 8.73e-01 | 0.3055 |
84277 | DNAJC30 | C38 | Human | Oral cavity | OSCC | 7.17e-04 | 5.24e-01 | 0.172 |
84277 | DNAJC30 | C46 | Human | Oral cavity | OSCC | 1.30e-06 | 3.13e-01 | 0.1673 |
84277 | DNAJC30 | C08 | Human | Oral cavity | OSCC | 4.47e-27 | 6.42e-01 | 0.1919 |
84277 | DNAJC30 | LN46 | Human | Oral cavity | OSCC | 1.80e-03 | 3.17e-01 | 0.1666 |
84277 | DNAJC30 | SYSMH1 | Human | Oral cavity | OSCC | 3.81e-06 | 2.01e-01 | 0.1127 |
84277 | DNAJC30 | SYSMH2 | Human | Oral cavity | OSCC | 5.24e-09 | 2.74e-01 | 0.2326 |
84277 | DNAJC30 | SYSMH3 | Human | Oral cavity | OSCC | 2.69e-14 | 4.32e-01 | 0.2442 |
84277 | DNAJC30 | SYSMH6 | Human | Oral cavity | OSCC | 1.97e-04 | 2.58e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003238618 | Esophagus | ESCC | regulation of intracellular transport | 243/8552 | 337/18723 | 3.20e-23 | 7.25e-21 | 243 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0045333110 | Esophagus | ESCC | cellular respiration | 173/8552 | 230/18723 | 4.53e-20 | 5.99e-18 | 173 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0009060110 | Esophagus | ESCC | aerobic respiration | 145/8552 | 189/18723 | 2.16e-18 | 2.21e-16 | 145 |
GO:0015980110 | Esophagus | ESCC | energy derivation by oxidation of organic compounds | 220/8552 | 318/18723 | 1.20e-17 | 1.09e-15 | 220 |
GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
GO:0006119111 | Esophagus | ESCC | oxidative phosphorylation | 106/8552 | 141/18723 | 8.19e-13 | 3.63e-11 | 106 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:0009141111 | Esophagus | ESCC | nucleoside triphosphate metabolic process | 78/8552 | 112/18723 | 2.36e-07 | 3.59e-06 | 78 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0046390110 | Esophagus | ESCC | ribose phosphate biosynthetic process | 119/8552 | 190/18723 | 1.73e-06 | 2.06e-05 | 119 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:0009144110 | Esophagus | ESCC | purine nucleoside triphosphate metabolic process | 61/8552 | 88/18723 | 6.06e-06 | 6.23e-05 | 61 |
GO:000919918 | Esophagus | ESCC | ribonucleoside triphosphate metabolic process | 61/8552 | 89/18723 | 1.07e-05 | 1.01e-04 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC30 | SNV | Missense_Mutation | c.497C>A | p.Ala166Asp | p.A166D | Q96LL9 | protein_coding | deleterious(0.04) | benign(0.397) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR | |
DNAJC30 | SNV | Missense_Mutation | c.206N>G | p.Tyr69Cys | p.Y69C | Q96LL9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
DNAJC30 | SNV | Missense_Mutation | c.582N>T | p.Glu194Asp | p.E194D | Q96LL9 | protein_coding | deleterious(0.04) | benign(0.079) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
DNAJC30 | SNV | Missense_Mutation | rs137909145 | c.520G>A | p.Glu174Lys | p.E174K | Q96LL9 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-AG-4007-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
DNAJC30 | SNV | Missense_Mutation | rs782201231 | c.169N>T | p.Pro57Ser | p.P57S | Q96LL9 | protein_coding | tolerated(0.62) | benign(0.029) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DNAJC30 | SNV | Missense_Mutation | c.107N>A | p.Arg36Lys | p.R36K | Q96LL9 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
DNAJC30 | SNV | Missense_Mutation | novel | c.233N>T | p.Pro78Leu | p.P78L | Q96LL9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-KP-A3W1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC30 | SNV | Missense_Mutation | novel | c.273N>G | p.Phe91Leu | p.F91L | Q96LL9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-86-7711-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
DNAJC30 | SNV | Missense_Mutation | novel | c.599N>T | p.Gly200Val | p.G200V | Q96LL9 | protein_coding | deleterious(0.02) | possibly_damaging(0.66) | TCGA-37-4132-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DNAJC30 | SNV | Missense_Mutation | novel | c.251N>T | p.Ser84Ile | p.S84I | Q96LL9 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-52-7809-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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