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Gene: DNAAF5 |
Gene summary for DNAAF5 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DNAAF5 | Gene ID | 54919 |
Gene name | dynein axonemal assembly factor 5 | |
Gene Alias | CILD18 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B3KPE2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54919 | DNAAF5 | C43 | Human | Oral cavity | OSCC | 5.01e-09 | 2.54e-01 | 0.1704 |
54919 | DNAAF5 | C46 | Human | Oral cavity | OSCC | 9.14e-11 | 2.64e-01 | 0.1673 |
54919 | DNAAF5 | C51 | Human | Oral cavity | OSCC | 1.62e-04 | 3.49e-01 | 0.2674 |
54919 | DNAAF5 | C08 | Human | Oral cavity | OSCC | 1.90e-14 | 4.34e-01 | 0.1919 |
54919 | DNAAF5 | SYSMH2 | Human | Oral cavity | OSCC | 8.65e-06 | 2.88e-01 | 0.2326 |
54919 | DNAAF5 | SYSMH3 | Human | Oral cavity | OSCC | 3.38e-12 | 3.36e-01 | 0.2442 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAAF5 | SNV | Missense_Mutation | novel | c.2419N>A | p.Asp807Asn | p.D807N | Q86Y56 | protein_coding | tolerated(0.24) | benign(0.038) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DNAAF5 | SNV | Missense_Mutation | novel | c.898N>C | p.Glu300Gln | p.E300Q | Q86Y56 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A2-A0YH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
DNAAF5 | SNV | Missense_Mutation | novel | c.949C>A | p.Gln317Lys | p.Q317K | Q86Y56 | protein_coding | deleterious(0.01) | benign(0.214) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
DNAAF5 | SNV | Missense_Mutation | rs773744343 | c.1507N>T | p.Ala503Ser | p.A503S | Q86Y56 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
DNAAF5 | SNV | Missense_Mutation | c.2311C>G | p.Leu771Val | p.L771V | Q86Y56 | protein_coding | deleterious(0.01) | possibly_damaging(0.902) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
DNAAF5 | SNV | Missense_Mutation | c.2417N>C | p.Gln806Pro | p.Q806P | Q86Y56 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DNAAF5 | SNV | Missense_Mutation | c.2366A>G | p.Tyr789Cys | p.Y789C | Q86Y56 | protein_coding | tolerated(0.11) | possibly_damaging(0.49) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DNAAF5 | SNV | Missense_Mutation | novel | c.2081N>G | p.Gln694Arg | p.Q694R | Q86Y56 | protein_coding | tolerated(0.11) | benign(0.218) | TCGA-AG-3584-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD |
DNAAF5 | SNV | Missense_Mutation | rs534027051 | c.1714G>A | p.Ala572Thr | p.A572T | Q86Y56 | protein_coding | tolerated(0.32) | benign(0.127) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
DNAAF5 | SNV | Missense_Mutation | rs749838774 | c.829N>T | p.Arg277Cys | p.R277C | Q86Y56 | protein_coding | deleterious(0) | possibly_damaging(0.891) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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