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Gene: DCUN1D5 |
Gene summary for DCUN1D5 |
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Gene information | Species | Human | Gene symbol | DCUN1D5 | Gene ID | 84259 |
Gene name | defective in cullin neddylation 1 domain containing 5 | |
Gene Alias | DCNL5 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | B4DP84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84259 | DCUN1D5 | P91T-E | Human | Esophagus | ESCC | 4.08e-14 | 1.69e+00 | 0.1828 |
84259 | DCUN1D5 | P107T-E | Human | Esophagus | ESCC | 1.48e-103 | 5.01e+00 | 0.171 |
84259 | DCUN1D5 | P127T-E | Human | Esophagus | ESCC | 1.96e-22 | 1.90e-01 | 0.0826 |
84259 | DCUN1D5 | P128T-E | Human | Esophagus | ESCC | 1.73e-71 | 3.84e+00 | 0.1241 |
84259 | DCUN1D5 | P130T-E | Human | Esophagus | ESCC | 7.96e-111 | 2.86e+00 | 0.1676 |
84259 | DCUN1D5 | HCC1_Meng | Human | Liver | HCC | 3.34e-82 | 5.02e-01 | 0.0246 |
84259 | DCUN1D5 | HCC2_Meng | Human | Liver | HCC | 6.96e-03 | -4.95e-02 | 0.0107 |
84259 | DCUN1D5 | cirrhotic1 | Human | Liver | Cirrhotic | 1.97e-02 | 6.55e-02 | 0.0202 |
84259 | DCUN1D5 | cirrhotic3 | Human | Liver | Cirrhotic | 2.19e-04 | 1.27e-01 | 0.0215 |
84259 | DCUN1D5 | HCC2 | Human | Liver | HCC | 4.72e-13 | 2.82e+00 | 0.5341 |
84259 | DCUN1D5 | Pt13.b | Human | Liver | HCC | 1.07e-07 | 1.60e-01 | 0.0251 |
84259 | DCUN1D5 | Pt14.b | Human | Liver | HCC | 7.32e-04 | 2.64e-01 | 0.018 |
84259 | DCUN1D5 | S014 | Human | Liver | HCC | 5.62e-30 | 1.06e+00 | 0.2254 |
84259 | DCUN1D5 | S015 | Human | Liver | HCC | 2.08e-27 | 1.23e+00 | 0.2375 |
84259 | DCUN1D5 | S016 | Human | Liver | HCC | 2.77e-39 | 1.25e+00 | 0.2243 |
84259 | DCUN1D5 | S027 | Human | Liver | HCC | 9.60e-11 | 8.52e-01 | 0.2446 |
84259 | DCUN1D5 | S028 | Human | Liver | HCC | 2.16e-21 | 1.08e+00 | 0.2503 |
84259 | DCUN1D5 | S029 | Human | Liver | HCC | 5.67e-19 | 9.56e-01 | 0.2581 |
84259 | DCUN1D5 | C04 | Human | Oral cavity | OSCC | 6.55e-41 | 2.36e+00 | 0.2633 |
84259 | DCUN1D5 | C21 | Human | Oral cavity | OSCC | 1.61e-92 | 4.99e+00 | 0.2678 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332027 | Esophagus | HGIN | regulation of protein modification by small protein conjugation or removal | 78/2587 | 242/18723 | 1.40e-13 | 2.26e-11 | 78 |
GO:003139627 | Esophagus | HGIN | regulation of protein ubiquitination | 64/2587 | 210/18723 | 3.02e-10 | 2.71e-08 | 64 |
GO:19033228 | Esophagus | HGIN | positive regulation of protein modification by small protein conjugation or removal | 35/2587 | 138/18723 | 2.11e-04 | 3.88e-03 | 35 |
GO:001604919 | Esophagus | HGIN | cell growth | 93/2587 | 482/18723 | 4.49e-04 | 6.62e-03 | 93 |
GO:00451166 | Esophagus | HGIN | protein neddylation | 8/2587 | 18/18723 | 1.58e-03 | 1.79e-02 | 8 |
GO:00313987 | Esophagus | HGIN | positive regulation of protein ubiquitination | 28/2587 | 119/18723 | 2.89e-03 | 2.81e-02 | 28 |
GO:000155818 | Esophagus | HGIN | regulation of cell growth | 76/2587 | 414/18723 | 5.40e-03 | 4.42e-02 | 76 |
GO:1903320111 | Esophagus | ESCC | regulation of protein modification by small protein conjugation or removal | 181/8552 | 242/18723 | 1.80e-20 | 2.60e-18 | 181 |
GO:0031396111 | Esophagus | ESCC | regulation of protein ubiquitination | 154/8552 | 210/18723 | 2.70e-16 | 2.04e-14 | 154 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:190332216 | Esophagus | ESCC | positive regulation of protein modification by small protein conjugation or removal | 99/8552 | 138/18723 | 4.39e-10 | 1.16e-08 | 99 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:005143819 | Esophagus | ESCC | regulation of ubiquitin-protein transferase activity | 38/8552 | 53/18723 | 1.10e-04 | 7.69e-04 | 38 |
GO:004511614 | Esophagus | ESCC | protein neddylation | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
GO:00514433 | Esophagus | ESCC | positive regulation of ubiquitin-protein transferase activity | 21/8552 | 31/18723 | 1.10e-02 | 3.70e-02 | 21 |
GO:190332012 | Liver | Cirrhotic | regulation of protein modification by small protein conjugation or removal | 105/4634 | 242/18723 | 1.43e-10 | 7.43e-09 | 105 |
GO:003139612 | Liver | Cirrhotic | regulation of protein ubiquitination | 89/4634 | 210/18723 | 1.40e-08 | 5.30e-07 | 89 |
GO:001604911 | Liver | Cirrhotic | cell growth | 160/4634 | 482/18723 | 1.50e-05 | 2.07e-04 | 160 |
GO:19033222 | Liver | Cirrhotic | positive regulation of protein modification by small protein conjugation or removal | 52/4634 | 138/18723 | 4.91e-04 | 3.94e-03 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCUN1D5 | SNV | Missense_Mutation | c.643G>A | p.Asp215Asn | p.D215N | Q9BTE7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
DCUN1D5 | SNV | Missense_Mutation | novel | c.400G>A | p.Asp134Asn | p.D134N | Q9BTE7 | protein_coding | tolerated(0.05) | possibly_damaging(0.856) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
DCUN1D5 | SNV | Missense_Mutation | c.184N>A | p.Asp62Asn | p.D62N | Q9BTE7 | protein_coding | tolerated(0.11) | benign(0.259) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
DCUN1D5 | SNV | Missense_Mutation | rs774048924 | c.407N>T | p.Ser136Leu | p.S136L | Q9BTE7 | protein_coding | tolerated(0.67) | benign(0.005) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCUN1D5 | SNV | Missense_Mutation | rs778617984 | c.26C>T | p.Ser9Phe | p.S9F | Q9BTE7 | protein_coding | deleterious(0.03) | benign(0.092) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DCUN1D5 | SNV | Missense_Mutation | rs774048924 | c.407C>T | p.Ser136Leu | p.S136L | Q9BTE7 | protein_coding | tolerated(0.67) | benign(0.005) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCUN1D5 | SNV | Missense_Mutation | novel | c.131A>G | p.Glu44Gly | p.E44G | Q9BTE7 | protein_coding | deleterious(0.04) | benign(0.044) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
DCUN1D5 | SNV | Missense_Mutation | novel | c.98N>A | p.Ser33Tyr | p.S33Y | Q9BTE7 | protein_coding | deleterious(0.02) | possibly_damaging(0.615) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
DCUN1D5 | SNV | Missense_Mutation | novel | c.389N>T | p.Ser130Leu | p.S130L | Q9BTE7 | protein_coding | deleterious(0.04) | benign(0.02) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DCUN1D5 | SNV | Missense_Mutation | c.487N>G | p.Lys163Glu | p.K163E | Q9BTE7 | protein_coding | tolerated(0.29) | possibly_damaging(0.842) | TCGA-D1-A17R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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