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Gene: DCTN4 |
Gene summary for DCTN4 |
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Gene information | Species | Human | Gene symbol | DCTN4 | Gene ID | 51164 |
Gene name | dynactin subunit 4 | |
Gene Alias | DYN4 | |
Cytomap | 5q33.1 | |
Gene Type | protein-coding | GO ID | GO:0000775 | UniProtAcc | Q9NSJ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51164 | DCTN4 | P127T-E | Human | Esophagus | ESCC | 1.30e-09 | 1.02e-01 | 0.0826 |
51164 | DCTN4 | P128T-E | Human | Esophagus | ESCC | 2.73e-36 | 1.16e+00 | 0.1241 |
51164 | DCTN4 | P130T-E | Human | Esophagus | ESCC | 1.33e-35 | 6.44e-01 | 0.1676 |
51164 | DCTN4 | HCC1_Meng | Human | Liver | HCC | 3.55e-59 | 4.21e-02 | 0.0246 |
51164 | DCTN4 | HCC2_Meng | Human | Liver | HCC | 6.02e-22 | 8.87e-02 | 0.0107 |
51164 | DCTN4 | HCC1 | Human | Liver | HCC | 1.03e-04 | 3.84e+00 | 0.5336 |
51164 | DCTN4 | HCC2 | Human | Liver | HCC | 1.58e-10 | 3.61e+00 | 0.5341 |
51164 | DCTN4 | Pt13.b | Human | Liver | HCC | 4.33e-03 | 4.82e-02 | 0.0251 |
51164 | DCTN4 | S014 | Human | Liver | HCC | 1.56e-05 | 4.02e-01 | 0.2254 |
51164 | DCTN4 | S015 | Human | Liver | HCC | 9.86e-07 | 3.86e-01 | 0.2375 |
51164 | DCTN4 | S016 | Human | Liver | HCC | 3.89e-09 | 3.69e-01 | 0.2243 |
51164 | DCTN4 | S028 | Human | Liver | HCC | 1.21e-07 | 4.77e-01 | 0.2503 |
51164 | DCTN4 | S029 | Human | Liver | HCC | 4.07e-09 | 5.78e-01 | 0.2581 |
51164 | DCTN4 | C21 | Human | Oral cavity | OSCC | 1.34e-16 | 5.80e-01 | 0.2678 |
51164 | DCTN4 | C30 | Human | Oral cavity | OSCC | 9.12e-09 | 6.25e-01 | 0.3055 |
51164 | DCTN4 | C43 | Human | Oral cavity | OSCC | 5.41e-12 | 1.54e-01 | 0.1704 |
51164 | DCTN4 | C46 | Human | Oral cavity | OSCC | 1.11e-05 | 2.75e-01 | 0.1673 |
51164 | DCTN4 | C51 | Human | Oral cavity | OSCC | 1.76e-05 | 3.29e-01 | 0.2674 |
51164 | DCTN4 | C08 | Human | Oral cavity | OSCC | 2.19e-12 | 2.58e-01 | 0.1919 |
51164 | DCTN4 | EOLP-1 | Human | Oral cavity | EOLP | 2.02e-15 | 3.65e-01 | -0.0202 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501630 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa0501430 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa0502230 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa049627 | Esophagus | HGIN | Vasopressin-regulated water reabsorption | 14/1383 | 44/8465 | 8.21e-03 | 4.71e-02 | 3.74e-02 | 14 |
hsa05016113 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa05014113 | Esophagus | HGIN | Amyotrophic lateral sclerosis | 140/1383 | 364/8465 | 2.13e-25 | 1.16e-23 | 9.19e-24 | 140 |
hsa05022113 | Esophagus | HGIN | Pathways of neurodegeneration - multiple diseases | 153/1383 | 476/8465 | 1.22e-18 | 4.41e-17 | 3.50e-17 | 153 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa0496214 | Esophagus | HGIN | Vasopressin-regulated water reabsorption | 14/1383 | 44/8465 | 8.21e-03 | 4.71e-02 | 3.74e-02 | 14 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0496223 | Esophagus | ESCC | Vasopressin-regulated water reabsorption | 33/4205 | 44/8465 | 5.27e-04 | 1.78e-03 | 9.13e-04 | 33 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0496233 | Esophagus | ESCC | Vasopressin-regulated water reabsorption | 33/4205 | 44/8465 | 5.27e-04 | 1.78e-03 | 9.13e-04 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCTN4 | SNV | Missense_Mutation | c.665N>C | p.Lys222Thr | p.K222T | Q9UJW0 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
DCTN4 | SNV | Missense_Mutation | c.201G>C | p.Lys67Asn | p.K67N | Q9UJW0 | protein_coding | deleterious(0) | benign(0.31) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DCTN4 | SNV | Missense_Mutation | c.262N>T | p.Thr88Ser | p.T88S | Q9UJW0 | protein_coding | tolerated(0.18) | possibly_damaging(0.71) | TCGA-BH-A202-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
DCTN4 | SNV | Missense_Mutation | c.1189N>C | p.Asp397His | p.D397H | Q9UJW0 | protein_coding | tolerated(0.06) | possibly_damaging(0.838) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
DCTN4 | SNV | Missense_Mutation | novel | c.1285N>G | p.Lys429Glu | p.K429E | Q9UJW0 | protein_coding | tolerated(0.11) | benign(0.117) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DCTN4 | SNV | Missense_Mutation | c.847C>T | p.Arg283Cys | p.R283C | Q9UJW0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DCTN4 | SNV | Missense_Mutation | novel | c.491N>A | p.Arg164His | p.R164H | Q9UJW0 | protein_coding | tolerated(0.12) | benign(0.165) | TCGA-DS-A7WF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
DCTN4 | SNV | Missense_Mutation | c.847N>T | p.Arg283Cys | p.R283C | Q9UJW0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DCTN4 | SNV | Missense_Mutation | c.35A>T | p.Tyr12Phe | p.Y12F | Q9UJW0 | protein_coding | deleterious(0.04) | possibly_damaging(0.647) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DCTN4 | SNV | Missense_Mutation | novel | c.973N>T | p.Arg325Cys | p.R325C | Q9UJW0 | protein_coding | tolerated(0.12) | possibly_damaging(0.764) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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