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Gene: CYTH1 |
Gene summary for CYTH1 |
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Gene information | Species | Human | Gene symbol | CYTH1 | Gene ID | 9267 |
Gene name | cytohesin 1 | |
Gene Alias | B2-1 | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q15438 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9267 | CYTH1 | P57T-E | Human | Esophagus | ESCC | 1.95e-17 | 3.66e-01 | 0.0926 |
9267 | CYTH1 | P61T-E | Human | Esophagus | ESCC | 7.94e-13 | 2.56e-01 | 0.099 |
9267 | CYTH1 | P62T-E | Human | Esophagus | ESCC | 2.79e-50 | 8.54e-01 | 0.1302 |
9267 | CYTH1 | P65T-E | Human | Esophagus | ESCC | 1.69e-22 | 3.61e-01 | 0.0978 |
9267 | CYTH1 | P74T-E | Human | Esophagus | ESCC | 2.72e-10 | 2.72e-01 | 0.1479 |
9267 | CYTH1 | P75T-E | Human | Esophagus | ESCC | 1.27e-38 | 7.75e-01 | 0.1125 |
9267 | CYTH1 | P76T-E | Human | Esophagus | ESCC | 3.07e-17 | 3.67e-01 | 0.1207 |
9267 | CYTH1 | P79T-E | Human | Esophagus | ESCC | 2.84e-08 | 1.16e-01 | 0.1154 |
9267 | CYTH1 | P80T-E | Human | Esophagus | ESCC | 1.40e-28 | 9.49e-01 | 0.155 |
9267 | CYTH1 | P82T-E | Human | Esophagus | ESCC | 9.78e-14 | 4.34e-01 | 0.1072 |
9267 | CYTH1 | P83T-E | Human | Esophagus | ESCC | 2.53e-17 | 6.06e-01 | 0.1738 |
9267 | CYTH1 | P84T-E | Human | Esophagus | ESCC | 9.48e-10 | 3.98e-01 | 0.0933 |
9267 | CYTH1 | P89T-E | Human | Esophagus | ESCC | 2.87e-06 | 5.50e-01 | 0.1752 |
9267 | CYTH1 | P91T-E | Human | Esophagus | ESCC | 1.20e-07 | 1.11e+00 | 0.1828 |
9267 | CYTH1 | P94T-E | Human | Esophagus | ESCC | 6.56e-05 | 3.98e-01 | 0.0879 |
9267 | CYTH1 | P104T-E | Human | Esophagus | ESCC | 1.11e-06 | 5.05e-01 | 0.0931 |
9267 | CYTH1 | P107T-E | Human | Esophagus | ESCC | 1.17e-23 | 6.69e-01 | 0.171 |
9267 | CYTH1 | P127T-E | Human | Esophagus | ESCC | 2.06e-21 | 3.28e-01 | 0.0826 |
9267 | CYTH1 | P128T-E | Human | Esophagus | ESCC | 8.21e-15 | 6.78e-01 | 0.1241 |
9267 | CYTH1 | P130T-E | Human | Esophagus | ESCC | 1.78e-39 | 8.19e-01 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071639 | Cervix | CC | establishment or maintenance of cell polarity | 63/2311 | 218/18723 | 4.25e-11 | 8.76e-09 | 63 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00300108 | Cervix | CC | establishment of cell polarity | 42/2311 | 143/18723 | 4.30e-08 | 2.62e-06 | 42 |
GO:00465785 | Cervix | CC | regulation of Ras protein signal transduction | 44/2311 | 189/18723 | 2.05e-05 | 3.73e-04 | 44 |
GO:00901627 | Cervix | CC | establishment of epithelial cell polarity | 11/2311 | 31/18723 | 7.87e-04 | 6.96e-03 | 11 |
GO:000716310 | Endometrium | AEH | establishment or maintenance of cell polarity | 54/2100 | 218/18723 | 1.30e-08 | 8.47e-07 | 54 |
GO:00300109 | Endometrium | AEH | establishment of cell polarity | 36/2100 | 143/18723 | 2.19e-06 | 6.49e-05 | 36 |
GO:00510567 | Endometrium | AEH | regulation of small GTPase mediated signal transduction | 59/2100 | 302/18723 | 1.43e-05 | 3.03e-04 | 59 |
GO:00072657 | Endometrium | AEH | Ras protein signal transduction | 63/2100 | 337/18723 | 3.09e-05 | 5.66e-04 | 63 |
GO:00465786 | Endometrium | AEH | regulation of Ras protein signal transduction | 36/2100 | 189/18723 | 1.01e-03 | 8.97e-03 | 36 |
GO:00901628 | Endometrium | AEH | establishment of epithelial cell polarity | 10/2100 | 31/18723 | 1.48e-03 | 1.23e-02 | 10 |
GO:000716315 | Endometrium | EEC | establishment or maintenance of cell polarity | 56/2168 | 218/18723 | 5.41e-09 | 3.57e-07 | 56 |
GO:003001014 | Endometrium | EEC | establishment of cell polarity | 36/2168 | 143/18723 | 4.57e-06 | 1.15e-04 | 36 |
GO:005105612 | Endometrium | EEC | regulation of small GTPase mediated signal transduction | 61/2168 | 302/18723 | 9.42e-06 | 2.08e-04 | 61 |
GO:000726513 | Endometrium | EEC | Ras protein signal transduction | 64/2168 | 337/18723 | 4.31e-05 | 7.10e-04 | 64 |
GO:004657813 | Endometrium | EEC | regulation of Ras protein signal transduction | 37/2168 | 189/18723 | 9.23e-04 | 8.32e-03 | 37 |
GO:009016213 | Endometrium | EEC | establishment of epithelial cell polarity | 10/2168 | 31/18723 | 1.89e-03 | 1.45e-02 | 10 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513020 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa05130110 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0513126 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0513026 | Endometrium | AEH | Pathogenic Escherichia coli infection | 50/1197 | 197/8465 | 1.72e-05 | 1.86e-04 | 1.36e-04 | 50 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa05131111 | Endometrium | AEH | Shigellosis | 78/1197 | 247/8465 | 9.23e-13 | 2.00e-11 | 1.46e-11 | 78 |
hsa05132112 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa05130112 | Endometrium | AEH | Pathogenic Escherichia coli infection | 50/1197 | 197/8465 | 1.72e-05 | 1.86e-04 | 1.36e-04 | 50 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0513127 | Endometrium | EEC | Shigellosis | 79/1237 | 247/8465 | 1.80e-12 | 3.95e-11 | 2.95e-11 | 79 |
hsa0513227 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0513027 | Endometrium | EEC | Pathogenic Escherichia coli infection | 51/1237 | 197/8465 | 1.98e-05 | 2.28e-04 | 1.70e-04 | 51 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYTH1 | insertion | Frame_Shift_Ins | novel | c.1142_1143insGTTTGTTTGTTTTTGCC | p.Phe381LeufsTer65 | p.F381Lfs*65 | Q15438 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CYTH1 | deletion | In_Frame_Del | c.1093_1095delNNN | p.Lys365del | p.K365del | Q15438 | protein_coding | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
CYTH1 | SNV | Missense_Mutation | novel | c.52C>G | p.Gln18Glu | p.Q18E | Q15438 | protein_coding | tolerated(1) | benign(0) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CYTH1 | SNV | Missense_Mutation | c.973G>C | p.Glu325Gln | p.E325Q | Q15438 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CYTH1 | SNV | Missense_Mutation | c.215N>C | p.Lys72Thr | p.K72T | Q15438 | protein_coding | deleterious(0) | possibly_damaging(0.887) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CYTH1 | SNV | Missense_Mutation | c.734A>C | p.Lys245Thr | p.K245T | Q15438 | protein_coding | deleterious(0.01) | benign(0.245) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CYTH1 | SNV | Missense_Mutation | novel | c.554N>A | p.Thr185Asn | p.T185N | Q15438 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CYTH1 | SNV | Missense_Mutation | rs778692007 | c.811G>A | p.Gly271Arg | p.G271R | Q15438 | protein_coding | tolerated(0.2) | possibly_damaging(0.807) | TCGA-DY-A1H8-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CYTH1 | insertion | Frame_Shift_Ins | novel | c.639dupG | p.Phe214ValfsTer10 | p.F214Vfs*10 | Q15438 | protein_coding | TCGA-AA-3860-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | ||
CYTH1 | insertion | Frame_Shift_Ins | novel | c.728_729insTAAGTCTCAG | p.Phe244LysfsTer5 | p.F244Kfs*5 | Q15438 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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