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Gene: CPVL |
Gene summary for CPVL |
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Gene information | Species | Human | Gene symbol | CPVL | Gene ID | 54504 |
Gene name | carboxypeptidase vitellogenic like | |
Gene Alias | HVLP | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024RA40 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54504 | CPVL | ATC09 | Human | Thyroid | ATC | 4.83e-05 | -4.70e-01 | 0.2871 |
54504 | CPVL | ATC12 | Human | Thyroid | ATC | 3.53e-27 | -7.59e-01 | 0.34 |
54504 | CPVL | ATC13 | Human | Thyroid | ATC | 1.02e-04 | 3.97e-01 | 0.34 |
54504 | CPVL | ATC1 | Human | Thyroid | ATC | 4.28e-07 | -4.53e-01 | 0.2878 |
54504 | CPVL | ATC4 | Human | Thyroid | ATC | 2.49e-16 | -7.58e-01 | 0.34 |
54504 | CPVL | ATC5 | Human | Thyroid | ATC | 2.00e-05 | 5.00e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPVL | SNV | Missense_Mutation | rs775870649 | c.694G>A | p.Gly232Arg | p.G232R | Q9H3G5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPVL | SNV | Missense_Mutation | novel | c.533N>T | p.Asp178Val | p.D178V | Q9H3G5 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BH-A209-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CPVL | SNV | Missense_Mutation | c.385G>T | p.Val129Phe | p.V129F | Q9H3G5 | protein_coding | deleterious(0.04) | probably_damaging(0.938) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPVL | SNV | Missense_Mutation | c.279N>A | p.Phe93Leu | p.F93L | Q9H3G5 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CPVL | deletion | Frame_Shift_Del | novel | c.726delN | p.Glu243AsnfsTer4 | p.E243Nfs*4 | Q9H3G5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CPVL | deletion | Frame_Shift_Del | novel | c.94delN | p.Ser32ProfsTer29 | p.S32Pfs*29 | Q9H3G5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CPVL | SNV | Missense_Mutation | c.574G>A | p.Glu192Lys | p.E192K | Q9H3G5 | protein_coding | tolerated(0.1) | benign(0.281) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CPVL | deletion | Frame_Shift_Del | c.794delN | p.Lys265SerfsTer11 | p.K265Sfs*11 | Q9H3G5 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
CPVL | SNV | Missense_Mutation | c.23N>C | p.Val8Ala | p.V8A | Q9H3G5 | protein_coding | tolerated(0.54) | benign(0) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CPVL | SNV | Missense_Mutation | c.949N>G | p.Phe317Val | p.F317V | Q9H3G5 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-AA-3818-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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