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Gene: COG1 |
Gene summary for COG1 |
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Gene information | Species | Human | Gene symbol | COG1 | Gene ID | 9382 |
Gene name | component of oligomeric golgi complex 1 | |
Gene Alias | CDG2G | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8WTW3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9382 | COG1 | HCC1_Meng | Human | Liver | HCC | 5.33e-44 | 6.60e-02 | 0.0246 |
9382 | COG1 | HCC2_Meng | Human | Liver | HCC | 2.20e-04 | 1.88e-02 | 0.0107 |
9382 | COG1 | S015 | Human | Liver | HCC | 3.41e-08 | 4.35e-01 | 0.2375 |
9382 | COG1 | S016 | Human | Liver | HCC | 2.30e-07 | 3.10e-01 | 0.2243 |
9382 | COG1 | S027 | Human | Liver | HCC | 2.85e-03 | 4.67e-01 | 0.2446 |
9382 | COG1 | S028 | Human | Liver | HCC | 4.86e-12 | 5.04e-01 | 0.2503 |
9382 | COG1 | S029 | Human | Liver | HCC | 1.42e-16 | 7.02e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:0006891 | Liver | HCC | intra-Golgi vesicle-mediated transport | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COG1 | SNV | Missense_Mutation | c.2110N>A | p.Asp704Asn | p.D704N | Q8WTW3 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-A7-A0CD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
COG1 | SNV | Missense_Mutation | novel | c.488N>A | p.Ser163Asn | p.S163N | Q8WTW3 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
COG1 | SNV | Missense_Mutation | c.2446C>A | p.Leu816Ile | p.L816I | Q8WTW3 | protein_coding | tolerated(0.18) | benign(0.245) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
COG1 | SNV | Missense_Mutation | novel | c.1949N>T | p.Arg650Ile | p.R650I | Q8WTW3 | protein_coding | deleterious(0) | benign(0.193) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COG1 | SNV | Missense_Mutation | novel | c.1525N>C | p.Ala509Pro | p.A509P | Q8WTW3 | protein_coding | deleterious(0.03) | possibly_damaging(0.669) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COG1 | SNV | Missense_Mutation | c.997N>T | p.Pro333Ser | p.P333S | Q8WTW3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COG1 | SNV | Missense_Mutation | rs766953526 | c.1718N>G | p.Gln573Arg | p.Q573R | Q8WTW3 | protein_coding | tolerated(0.32) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COG1 | SNV | Missense_Mutation | c.574N>G | p.His192Asp | p.H192D | Q8WTW3 | protein_coding | deleterious(0.03) | benign(0.048) | TCGA-C8-A1HK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COG1 | SNV | Missense_Mutation | novel | c.2837A>G | p.Asp946Gly | p.D946G | Q8WTW3 | protein_coding | deleterious(0.01) | benign(0.34) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
COG1 | SNV | Missense_Mutation | novel | c.2057N>A | p.Ser686Asn | p.S686N | Q8WTW3 | protein_coding | deleterious(0) | possibly_damaging(0.632) | TCGA-XX-A899-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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