Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CLDN1

Gene summary for CLDN1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CLDN1

Gene ID

9076

Gene nameclaudin 1
Gene AliasCLD1
Cytomap3q28
Gene Typeprotein-coding
GO ID

GO:0001885

UniProtAcc

A5JSJ9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9076CLDN1P80T-EHumanEsophagusESCC9.55e-694.11e+000.155
9076CLDN1P82T-EHumanEsophagusESCC2.69e-182.40e+000.1072
9076CLDN1P83T-EHumanEsophagusESCC3.86e-522.94e+000.1738
9076CLDN1P84T-EHumanEsophagusESCC5.80e-048.32e-010.0933
9076CLDN1P89T-EHumanEsophagusESCC8.54e-121.11e+000.1752
9076CLDN1P107T-EHumanEsophagusESCC3.63e-431.72e+000.171
9076CLDN1P126T-EHumanEsophagusESCC3.63e-031.58e+000.1125
9076CLDN1P127T-EHumanEsophagusESCC3.42e-541.74e+000.0826
9076CLDN1P128T-EHumanEsophagusESCC1.49e-502.19e+000.1241
9076CLDN1P130T-EHumanEsophagusESCC9.14e-1243.74e+000.1676
9076CLDN1S42HumanLiverHCC2.19e-03-3.91e-01-0.0103
9076CLDN1S43HumanLiverCirrhotic1.05e-371.22e-01-0.0187
9076CLDN1S44HumanLiverHCC5.59e-03-8.48e-01-0.0083
9076CLDN1HCC1_MengHumanLiverHCC4.76e-502.77e-010.0246
9076CLDN1HCC2_MengHumanLiverHCC7.72e-37-4.54e-010.0107
9076CLDN1cirrhotic1HumanLiverCirrhotic4.84e-15-1.76e-010.0202
9076CLDN1cirrhotic2HumanLiverCirrhotic3.39e-16-2.38e-020.0201
9076CLDN1cirrhotic3HumanLiverCirrhotic2.76e-03-5.43e-020.0215
9076CLDN1p6HumanLiverCyst2.40e-07-8.48e-01-0.0218
9076CLDN1HCC1HumanLiverHCC3.05e-043.86e+000.5336
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001603210CervixCCviral process109/2311415/187235.40e-156.46e-12109
GO:004206010CervixCCwound healing109/2311422/187231.84e-141.57e-11109
GO:001905810CervixCCviral life cycle87/2311317/187232.20e-131.20e-1087
GO:00435884CervixCCskin development71/2311263/187238.04e-111.46e-0871
GO:005212610CervixCCmovement in host environment52/2311175/187237.03e-108.76e-0852
GO:004440910CervixCCentry into host47/2311151/187238.45e-101.03e-0747
GO:005170110CervixCCbiological process involved in interaction with host57/2311203/187231.18e-091.41e-0757
GO:00506737CervixCCepithelial cell proliferation98/2311437/187232.01e-092.15e-0798
GO:004671810CervixCCviral entry into host cell44/2311144/187235.47e-095.03e-0744
GO:004440310CervixCCbiological process involved in symbiotic interaction71/2311290/187237.94e-096.98e-0771
GO:00452169CervixCCcell-cell junction organization53/2311200/187233.83e-082.53e-0653
GO:00506787CervixCCregulation of epithelial cell proliferation83/2311381/187231.31e-076.42e-0683
GO:00075689CervixCCaging75/2311339/187232.75e-071.13e-0575
GO:00343298CervixCCcell junction assembly88/2311420/187233.42e-071.38e-0588
GO:00022379CervixCCresponse to molecule of bacterial origin78/2311363/187235.55e-072.06e-0578
GO:004854510CervixCCresponse to steroid hormone74/2311339/187235.71e-072.09e-0574
GO:19030349CervixCCregulation of response to wounding44/2311167/187236.33e-072.31e-0544
GO:00324969CervixCCresponse to lipopolysaccharide74/2311343/187239.15e-073.25e-0574
GO:00070439CervixCCcell-cell junction assembly39/2311146/187231.86e-065.94e-0539
GO:005087810CervixCCregulation of body fluid levels78/2311379/187233.20e-068.77e-0578
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513020CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa0453020CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa0467020CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa045147CervixCCCell adhesion molecules36/1267157/84654.94e-031.67e-029.86e-0336
hsa05130110CervixCCPathogenic Escherichia coli infection63/1267197/84659.28e-102.00e-081.19e-0863
hsa04530110CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa04670110CervixCCLeukocyte transendothelial migration36/1267114/84655.22e-064.83e-052.86e-0536
hsa0451412CervixCCCell adhesion molecules36/1267157/84654.94e-031.67e-029.86e-0336
hsa0513044CervixN_HPVPathogenic Escherichia coli infection25/349197/84654.71e-078.00e-066.25e-0625
hsa0451441CervixN_HPVCell adhesion molecules18/349157/84657.71e-058.06e-046.30e-0418
hsa0453025CervixN_HPVTight junction16/349169/84651.60e-031.01e-027.92e-0316
hsa0467045CervixN_HPVLeukocyte transendothelial migration12/349114/84652.50e-031.45e-021.13e-0212
hsa0513054CervixN_HPVPathogenic Escherichia coli infection25/349197/84654.71e-078.00e-066.25e-0625
hsa0451451CervixN_HPVCell adhesion molecules18/349157/84657.71e-058.06e-046.30e-0418
hsa0453035CervixN_HPVTight junction16/349169/84651.60e-031.01e-027.92e-0316
hsa0467055CervixN_HPVLeukocyte transendothelial migration12/349114/84652.50e-031.45e-021.13e-0212
hsa0513039EsophagusHGINPathogenic Escherichia coli infection54/1383197/84654.91e-056.15e-044.89e-0454
hsa0453039EsophagusHGINTight junction40/1383169/84658.18e-034.71e-023.74e-0240
hsa05130115EsophagusHGINPathogenic Escherichia coli infection54/1383197/84654.91e-056.15e-044.89e-0454
hsa04530115EsophagusHGINTight junction40/1383169/84658.18e-034.71e-023.74e-0240
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CLDN1SNVMissense_Mutationc.450N>Ap.Asp150Glup.D150EO95832protein_codingdeleterious(0.02)benign(0.403)TCGA-AC-A3YI-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanCR
CLDN1SNVMissense_Mutationnovelc.97N>Cp.Tyr33Hisp.Y33HO95832protein_codingdeleterious(0)possibly_damaging(0.722)TCGA-XX-A899-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanCR
CLDN1insertionIn_Frame_Insnovelc.228_229insAAAAAGTTATTTAACp.Thr76_Leu77insLysLysLeuPheAsnp.T76_L77insKKLFNO95832protein_codingTCGA-A8-A09G-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
CLDN1deletionFrame_Shift_Delnovelc.485delNp.Gly162ValfsTer73p.G162Vfs*73O95832protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
CLDN1SNVMissense_Mutationnovelc.391N>Gp.Leu131Valp.L131VO95832protein_codingtolerated(0.24)possibly_damaging(0.759)TCGA-MA-AA41-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CLDN1deletionFrame_Shift_Delc.194_195delNNp.Lys65SerfsTer3p.K65Sfs*3O95832protein_codingTCGA-G4-6309-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyxelodaPD
CLDN1SNVMissense_Mutationrs147881276c.631G>Ap.Val211Metp.V211MO95832protein_codingdeleterious(0.05)probably_damaging(0.992)TCGA-A5-A0VP-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
CLDN1SNVMissense_Mutationnovelc.221N>Tp.Ser74Ilep.S74IO95832protein_codingdeleterious(0.01)possibly_damaging(0.449)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
CLDN1SNVMissense_Mutationrs772600198c.331N>Ap.Asp111Asnp.D111NO95832protein_codingtolerated(0.35)benign(0.279)TCGA-AX-A1C5-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnspecificCarboplatinSD
CLDN1SNVMissense_Mutationrs754012333c.253N>Ap.Val85Metp.V85MO95832protein_codingdeleterious(0)probably_damaging(0.973)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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