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Gene: CKAP4 |
Gene summary for CKAP4 |
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Gene information | Species | Human | Gene symbol | CKAP4 | Gene ID | 10970 |
Gene name | cytoskeleton associated protein 4 | |
Gene Alias | CLIMP-63 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000323 | UniProtAcc | A0A024RBH2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10970 | CKAP4 | P1T-E | Human | Esophagus | ESCC | 8.25e-10 | 1.30e+00 | 0.0875 |
10970 | CKAP4 | P2T-E | Human | Esophagus | ESCC | 3.08e-114 | 2.95e+00 | 0.1177 |
10970 | CKAP4 | P4T-E | Human | Esophagus | ESCC | 6.94e-39 | 1.19e+00 | 0.1323 |
10970 | CKAP4 | P5T-E | Human | Esophagus | ESCC | 3.69e-04 | 2.89e-01 | 0.1327 |
10970 | CKAP4 | P8T-E | Human | Esophagus | ESCC | 1.63e-20 | 4.95e-01 | 0.0889 |
10970 | CKAP4 | P9T-E | Human | Esophagus | ESCC | 4.03e-12 | 4.00e-01 | 0.1131 |
10970 | CKAP4 | P10T-E | Human | Esophagus | ESCC | 1.45e-18 | 4.07e-01 | 0.116 |
10970 | CKAP4 | P11T-E | Human | Esophagus | ESCC | 1.94e-20 | 1.80e+00 | 0.1426 |
10970 | CKAP4 | P12T-E | Human | Esophagus | ESCC | 9.68e-29 | 8.44e-01 | 0.1122 |
10970 | CKAP4 | P15T-E | Human | Esophagus | ESCC | 9.44e-21 | 9.06e-01 | 0.1149 |
10970 | CKAP4 | P16T-E | Human | Esophagus | ESCC | 1.21e-63 | 1.57e+00 | 0.1153 |
10970 | CKAP4 | P17T-E | Human | Esophagus | ESCC | 5.63e-08 | 7.28e-01 | 0.1278 |
10970 | CKAP4 | P19T-E | Human | Esophagus | ESCC | 3.35e-10 | 1.31e+00 | 0.1662 |
10970 | CKAP4 | P20T-E | Human | Esophagus | ESCC | 2.21e-19 | 5.86e-01 | 0.1124 |
10970 | CKAP4 | P21T-E | Human | Esophagus | ESCC | 1.94e-56 | 1.75e+00 | 0.1617 |
10970 | CKAP4 | P22T-E | Human | Esophagus | ESCC | 1.42e-18 | 5.46e-01 | 0.1236 |
10970 | CKAP4 | P23T-E | Human | Esophagus | ESCC | 4.13e-25 | 1.14e+00 | 0.108 |
10970 | CKAP4 | P24T-E | Human | Esophagus | ESCC | 2.38e-17 | 8.48e-01 | 0.1287 |
10970 | CKAP4 | P26T-E | Human | Esophagus | ESCC | 2.12e-47 | 1.51e+00 | 0.1276 |
10970 | CKAP4 | P27T-E | Human | Esophagus | ESCC | 5.42e-23 | 9.34e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041416 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa041417 | Colorectum | MSI-H | Protein processing in endoplasmic reticulum | 46/797 | 174/8465 | 4.53e-11 | 9.78e-10 | 8.19e-10 | 46 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414139 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04141114 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CKAP4 | SNV | Missense_Mutation | c.1105N>C | p.Glu369Gln | p.E369Q | Q07065 | protein_coding | tolerated(0.1) | benign(0.269) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CKAP4 | SNV | Missense_Mutation | novel | c.1489C>A | p.Pro497Thr | p.P497T | Q07065 | protein_coding | deleterious(0.01) | possibly_damaging(0.862) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CKAP4 | SNV | Missense_Mutation | c.824N>T | p.Ser275Phe | p.S275F | Q07065 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CKAP4 | SNV | Missense_Mutation | c.719G>A | p.Arg240Gln | p.R240Q | Q07065 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CKAP4 | SNV | Missense_Mutation | rs141394460 | c.1094N>A | p.Arg365His | p.R365H | Q07065 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CKAP4 | SNV | Missense_Mutation | rs376479872 | c.604N>A | p.Glu202Lys | p.E202K | Q07065 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CKAP4 | SNV | Missense_Mutation | c.1251N>T | p.Glu417Asp | p.E417D | Q07065 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CKAP4 | SNV | Missense_Mutation | rs769777070 | c.979N>A | p.Glu327Lys | p.E327K | Q07065 | protein_coding | deleterious(0.01) | possibly_damaging(0.794) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CKAP4 | SNV | Missense_Mutation | novel | c.1052N>G | p.Ala351Gly | p.A351G | Q07065 | protein_coding | deleterious(0.02) | benign(0.124) | TCGA-AG-A036-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
CKAP4 | SNV | Missense_Mutation | rs771014402 | c.1450N>A | p.Gly484Ser | p.G484S | Q07065 | protein_coding | tolerated(0.81) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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