Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CENPB

Gene summary for CENPB

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CENPB

Gene ID

1059

Gene namecentromere protein B
Gene AliasCENPB
Cytomap20p13
Gene Typeprotein-coding
GO ID

GO:0000775

UniProtAcc

P07199


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1059CENPBP52T-EHumanEsophagusESCC4.74e-212.62e-010.1555
1059CENPBP54T-EHumanEsophagusESCC1.96e-096.42e-020.0975
1059CENPBP56T-EHumanEsophagusESCC1.65e-045.91e-010.1613
1059CENPBP57T-EHumanEsophagusESCC3.81e-045.05e-020.0926
1059CENPBP61T-EHumanEsophagusESCC9.21e-087.07e-020.099
1059CENPBP62T-EHumanEsophagusESCC1.74e-152.55e-010.1302
1059CENPBP65T-EHumanEsophagusESCC2.19e-152.10e-010.0978
1059CENPBP74T-EHumanEsophagusESCC1.33e-081.94e-010.1479
1059CENPBP75T-EHumanEsophagusESCC2.08e-161.75e-010.1125
1059CENPBP76T-EHumanEsophagusESCC7.24e-112.16e-010.1207
1059CENPBP79T-EHumanEsophagusESCC5.45e-101.86e-010.1154
1059CENPBP80T-EHumanEsophagusESCC1.57e-113.36e-010.155
1059CENPBP82T-EHumanEsophagusESCC2.33e-064.75e-010.1072
1059CENPBP83T-EHumanEsophagusESCC2.51e-269.29e-010.1738
1059CENPBP84T-EHumanEsophagusESCC3.74e-025.31e-020.0933
1059CENPBP89T-EHumanEsophagusESCC2.84e-053.35e-010.1752
1059CENPBP91T-EHumanEsophagusESCC1.56e-056.01e-010.1828
1059CENPBP104T-EHumanEsophagusESCC3.95e-039.82e-020.0931
1059CENPBP107T-EHumanEsophagusESCC2.12e-132.74e-010.171
1059CENPBP127T-EHumanEsophagusESCC1.00e-03-8.46e-020.0826
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
CENPBPARIStomachHealthyYTHDF3,NBL1,RRM2, etc.2.68e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CENPBSNVMissense_Mutationnovelc.1543N>Ap.Glu515Lysp.E515KP07199protein_codingdeleterious_low_confidence(0.02)benign(0.052)TCGA-E2-A14P-01Breastbreast invasive carcinomaFemale>=65III/IVTargeted Molecular therapytrastuzumabSD
CENPBdeletionFrame_Shift_Delnovelc.814delNp.Gln272ArgfsTer7p.Q272Rfs*7P07199protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
CENPBSNVMissense_Mutationnovelc.1612N>Cp.Glu538Glnp.E538QP07199protein_codingdeleterious_low_confidence(0.02)probably_damaging(0.992)TCGA-VS-A953-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
CENPBSNVMissense_Mutationnovelc.1369N>Tp.Asp457Tyrp.D457YP07199protein_codingtolerated_low_confidence(0.05)benign(0.261)TCGA-ZJ-AAXB-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CENPBdeletionIn_Frame_Delrs754367212c.1242_1256delAGAGGAGGAGGAAGAp.Glu415_Glu419delp.E415_E419delP07199protein_codingTCGA-EK-A3GM-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
CENPBSNVMissense_Mutationnovelc.869N>Ap.Arg290Hisp.R290HP07199protein_codingdeleterious(0)probably_damaging(0.957)TCGA-A6-3809-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
CENPBSNVMissense_Mutationnovelc.311C>Tp.Ala104Valp.A104VP07199protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AA-3947-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
CENPBSNVMissense_Mutationc.1130N>Tp.Pro377Leup.P377LP07199protein_codingdeleterious(0.03)possibly_damaging(0.83)TCGA-AG-3881-01Colorectumrectum adenocarcinomaFemale>=65I/IIUnknownUnknownSD
CENPBSNVMissense_Mutationrs765081320c.1585G>Ap.Asp529Asnp.D529NP07199protein_codingdeleterious_low_confidence(0.01)possibly_damaging(0.57)TCGA-AG-3902-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
CENPBdeletionFrame_Shift_Delrs772292203c.1312delNp.Glu438LysfsTer43p.E438Kfs*43P07199protein_codingTCGA-AZ-6598-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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