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Gene: CD47 |
Gene summary for CD47 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CD47 | Gene ID | 961 |
Gene name | CD47 molecule | |
Gene Alias | IAP | |
Cytomap | 3q13.12 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q08722 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
961 | CD47 | LZE8T | Human | Esophagus | ESCC | 1.83e-05 | 2.28e-02 | 0.067 |
961 | CD47 | LZE20T | Human | Esophagus | ESCC | 4.40e-09 | 4.72e-01 | 0.0662 |
961 | CD47 | LZE24T | Human | Esophagus | ESCC | 1.07e-23 | 1.09e+00 | 0.0596 |
961 | CD47 | LZE6T | Human | Esophagus | ESCC | 1.36e-05 | -2.03e-01 | 0.0845 |
961 | CD47 | P1T-E | Human | Esophagus | ESCC | 4.20e-03 | 7.93e-01 | 0.0875 |
961 | CD47 | P2T-E | Human | Esophagus | ESCC | 1.90e-40 | 1.02e+00 | 0.1177 |
961 | CD47 | P4T-E | Human | Esophagus | ESCC | 1.39e-10 | 4.31e-01 | 0.1323 |
961 | CD47 | P5T-E | Human | Esophagus | ESCC | 1.41e-52 | 1.84e+00 | 0.1327 |
961 | CD47 | P8T-E | Human | Esophagus | ESCC | 8.34e-56 | 1.53e+00 | 0.0889 |
961 | CD47 | P9T-E | Human | Esophagus | ESCC | 3.97e-10 | 6.17e-01 | 0.1131 |
961 | CD47 | P10T-E | Human | Esophagus | ESCC | 4.85e-12 | 2.17e-01 | 0.116 |
961 | CD47 | P11T-E | Human | Esophagus | ESCC | 2.18e-21 | 1.48e+00 | 0.1426 |
961 | CD47 | P12T-E | Human | Esophagus | ESCC | 3.44e-09 | 1.51e-01 | 0.1122 |
961 | CD47 | P15T-E | Human | Esophagus | ESCC | 1.48e-08 | 4.40e-01 | 0.1149 |
961 | CD47 | P16T-E | Human | Esophagus | ESCC | 5.62e-28 | 7.03e-01 | 0.1153 |
961 | CD47 | P17T-E | Human | Esophagus | ESCC | 5.98e-13 | 1.14e+00 | 0.1278 |
961 | CD47 | P19T-E | Human | Esophagus | ESCC | 2.66e-07 | 1.26e+00 | 0.1662 |
961 | CD47 | P20T-E | Human | Esophagus | ESCC | 6.70e-23 | 8.52e-01 | 0.1124 |
961 | CD47 | P21T-E | Human | Esophagus | ESCC | 3.87e-67 | 1.82e+00 | 0.1617 |
961 | CD47 | P22T-E | Human | Esophagus | ESCC | 1.84e-30 | 7.90e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00457859 | Breast | Precancer | positive regulation of cell adhesion | 52/1080 | 437/18723 | 5.74e-07 | 2.49e-05 | 52 |
GO:00507293 | Breast | Precancer | positive regulation of inflammatory response | 23/1080 | 142/18723 | 6.51e-06 | 1.81e-04 | 23 |
GO:0050727 | Breast | Precancer | regulation of inflammatory response | 44/1080 | 386/18723 | 1.26e-05 | 3.22e-04 | 44 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:00508707 | Breast | Precancer | positive regulation of T cell activation | 29/1080 | 216/18723 | 1.94e-05 | 4.58e-04 | 29 |
GO:19029059 | Breast | Precancer | positive regulation of supramolecular fiber organization | 28/1080 | 209/18723 | 2.79e-05 | 6.28e-04 | 28 |
GO:00321034 | Breast | Precancer | positive regulation of response to external stimulus | 46/1080 | 427/18723 | 3.41e-05 | 7.40e-04 | 46 |
GO:19029039 | Breast | Precancer | regulation of supramolecular fiber organization | 42/1080 | 383/18723 | 4.92e-05 | 1.04e-03 | 42 |
GO:19030396 | Breast | Precancer | positive regulation of leukocyte cell-cell adhesion | 30/1080 | 239/18723 | 5.13e-05 | 1.07e-03 | 30 |
GO:00313493 | Breast | Precancer | positive regulation of defense response | 33/1080 | 278/18723 | 6.79e-05 | 1.36e-03 | 33 |
GO:00026856 | Breast | Precancer | regulation of leukocyte migration | 27/1080 | 210/18723 | 7.93e-05 | 1.54e-03 | 27 |
GO:00508637 | Breast | Precancer | regulation of T cell activation | 37/1080 | 329/18723 | 8.04e-05 | 1.56e-03 | 37 |
GO:00224098 | Breast | Precancer | positive regulation of cell-cell adhesion | 33/1080 | 284/18723 | 1.03e-04 | 1.89e-03 | 33 |
GO:00071597 | Breast | Precancer | leukocyte cell-cell adhesion | 40/1080 | 371/18723 | 1.07e-04 | 1.94e-03 | 40 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00514959 | Breast | Precancer | positive regulation of cytoskeleton organization | 28/1080 | 226/18723 | 1.13e-04 | 2.04e-03 | 28 |
GO:00224079 | Breast | Precancer | regulation of cell-cell adhesion | 45/1080 | 448/18723 | 2.12e-04 | 3.30e-03 | 45 |
GO:19030377 | Breast | Precancer | regulation of leukocyte cell-cell adhesion | 36/1080 | 336/18723 | 2.61e-04 | 3.84e-03 | 36 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045124 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa0451211 | Cervix | HSIL_HPV | ECM-receptor interaction | 12/459 | 89/8465 | 2.95e-03 | 1.88e-02 | 1.52e-02 | 12 |
hsa045125 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
hsa0451212 | Prostate | BPH | ECM-receptor interaction | 28/1718 | 89/8465 | 8.33e-03 | 2.64e-02 | 1.64e-02 | 28 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | DCIS |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | DCIS |
THBS3 | CD47 | THBS3_CD47 | THBS | Breast | DCIS |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | IDC |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | IDC |
COMP | CD47 | COMP_CD47 | THBS | Breast | IDC |
THBS1 | CD47 | THBS1_CD47 | THBS | Breast | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Precancer |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | ADJ |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | CC |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | CC |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Healthy |
THBS1 | CD47 | THBS1_CD47 | THBS | Cervix | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Cervix | Precancer |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD47 | SNV | Missense_Mutation | c.352N>C | p.Glu118Gln | p.E118Q | Q08722 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CD47 | SNV | Missense_Mutation | c.640N>C | p.Val214Leu | p.V214L | Q08722 | protein_coding | deleterious(0) | possibly_damaging(0.813) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
CD47 | SNV | Missense_Mutation | novel | c.922N>A | p.Glu308Lys | p.E308K | Q08722 | protein_coding | deleterious(0.03) | probably_damaging(0.991) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
CD47 | SNV | Missense_Mutation | novel | c.459N>G | p.Ile153Met | p.I153M | Q08722 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | c.643A>T | p.Thr215Ser | p.T215S | Q08722 | protein_coding | deleterious(0) | benign(0.296) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CD47 | SNV | Missense_Mutation | c.942N>C | p.Lys314Asn | p.K314N | Q08722 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.996) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD47 | SNV | Missense_Mutation | novel | c.71N>C | p.Lys24Thr | p.K24T | Q08722 | protein_coding | tolerated(0.59) | benign(0.021) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CD47 | SNV | Missense_Mutation | c.478T>C | p.Phe160Leu | p.F160L | Q08722 | protein_coding | tolerated(0.64) | benign(0.272) | TCGA-CL-4957-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
CD47 | SNV | Missense_Mutation | novel | c.692N>T | p.Ala231Val | p.A231V | Q08722 | protein_coding | tolerated(0.71) | benign(0.185) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CD47 | SNV | Missense_Mutation | rs754405285 | c.785N>T | p.Ala262Val | p.A262V | Q08722 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ABT-510 | ABT-510 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | ALX148 | ALX-148 | ||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | TTI-621 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | CC-90002 | |||
961 | CD47 | DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | Hu5F9-G4 | MAGROLIMAB |
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