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Gene: CCDC137 |
Gene summary for CCDC137 |
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Gene information | Species | Human | Gene symbol | CCDC137 | Gene ID | 339230 |
Gene name | coiled-coil domain containing 137 | |
Gene Alias | RaRF | |
Cytomap | 17q25.3 | |
Gene Type | protein-coding | GO ID | GO:0001650 | UniProtAcc | Q6PK04 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339230 | CCDC137 | P107T-E | Human | Esophagus | ESCC | 2.40e-52 | 1.15e+00 | 0.171 |
339230 | CCDC137 | P127T-E | Human | Esophagus | ESCC | 1.02e-16 | 2.82e-01 | 0.0826 |
339230 | CCDC137 | P128T-E | Human | Esophagus | ESCC | 2.19e-27 | 9.00e-01 | 0.1241 |
339230 | CCDC137 | P130T-E | Human | Esophagus | ESCC | 2.64e-38 | 7.78e-01 | 0.1676 |
339230 | CCDC137 | HCC1_Meng | Human | Liver | HCC | 9.19e-65 | 1.44e-01 | 0.0246 |
339230 | CCDC137 | HCC2_Meng | Human | Liver | HCC | 1.36e-07 | 3.44e-02 | 0.0107 |
339230 | CCDC137 | HCC2 | Human | Liver | HCC | 1.25e-19 | 3.59e+00 | 0.5341 |
339230 | CCDC137 | Pt13.b | Human | Liver | HCC | 2.13e-10 | 1.02e-01 | 0.0251 |
339230 | CCDC137 | Pt14.a | Human | Liver | HCC | 1.06e-05 | 3.10e-01 | 0.0169 |
339230 | CCDC137 | Pt14.b | Human | Liver | HCC | 6.14e-07 | 2.27e-01 | 0.018 |
339230 | CCDC137 | S014 | Human | Liver | HCC | 3.99e-15 | 5.60e-01 | 0.2254 |
339230 | CCDC137 | S015 | Human | Liver | HCC | 1.76e-23 | 8.92e-01 | 0.2375 |
339230 | CCDC137 | S016 | Human | Liver | HCC | 2.37e-34 | 7.92e-01 | 0.2243 |
339230 | CCDC137 | S027 | Human | Liver | HCC | 1.09e-04 | 6.35e-01 | 0.2446 |
339230 | CCDC137 | S028 | Human | Liver | HCC | 1.66e-22 | 7.63e-01 | 0.2503 |
339230 | CCDC137 | S029 | Human | Liver | HCC | 2.22e-12 | 5.22e-01 | 0.2581 |
339230 | CCDC137 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 5.03e-22 | 7.38e-01 | -0.0166 |
339230 | CCDC137 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.03e-27 | 7.72e-01 | -0.0132 |
339230 | CCDC137 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.76e-40 | 9.40e-01 | -0.013 |
339230 | CCDC137 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.03e-32 | 8.76e-01 | -0.0121 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCDC137 | SNV | Missense_Mutation | rs375426067 | c.791N>T | p.Ala264Val | p.A264V | Q6PK04 | protein_coding | tolerated(0.27) | benign(0.001) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC137 | SNV | Missense_Mutation | c.186G>C | p.Glu62Asp | p.E62D | Q6PK04 | protein_coding | deleterious(0.03) | probably_damaging(0.96) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CCDC137 | SNV | Missense_Mutation | c.784N>C | p.Tyr262His | p.Y262H | Q6PK04 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CCDC137 | insertion | Frame_Shift_Ins | novel | c.229_230insGCAGCATCGCCCGCGGACGGGATCCGGCAACCCC | p.Met77SerfsTer18 | p.M77Sfs*18 | Q6PK04 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
CCDC137 | SNV | Missense_Mutation | rs371084134 | c.685N>T | p.Arg229Trp | p.R229W | Q6PK04 | protein_coding | deleterious(0) | possibly_damaging(0.859) | TCGA-AY-5543-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | oxaliplatin | SD |
CCDC137 | SNV | Missense_Mutation | novel | c.178N>A | p.Glu60Lys | p.E60K | Q6PK04 | protein_coding | deleterious(0.01) | benign(0.193) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCDC137 | SNV | Missense_Mutation | novel | c.338N>C | p.Lys113Thr | p.K113T | Q6PK04 | protein_coding | deleterious(0.01) | possibly_damaging(0.663) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CCDC137 | SNV | Missense_Mutation | novel | c.235N>G | p.Asn79Asp | p.N79D | Q6PK04 | protein_coding | tolerated(0.2) | benign(0.033) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCDC137 | SNV | Missense_Mutation | novel | c.242T>G | p.Ile81Ser | p.I81S | Q6PK04 | protein_coding | tolerated(0.76) | benign(0.058) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCDC137 | SNV | Missense_Mutation | novel | c.141G>T | p.Glu47Asp | p.E47D | Q6PK04 | protein_coding | tolerated(0.07) | benign(0.011) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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