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Gene: CCDC109B |
Gene summary for CCDC109B |
Gene summary. |
Gene information | Species | Human | Gene symbol | CCDC109B | Gene ID | 55013 |
Gene name | mitochondrial calcium uniporter dominant negative subunit beta | |
Gene Alias | CCDC109B | |
Cytomap | 4q25 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NWR8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55013 | CCDC109B | C43 | Human | Oral cavity | OSCC | 9.84e-37 | 7.17e-01 | 0.1704 |
55013 | CCDC109B | C46 | Human | Oral cavity | OSCC | 8.08e-40 | 8.92e-01 | 0.1673 |
55013 | CCDC109B | C51 | Human | Oral cavity | OSCC | 5.97e-39 | 1.45e+00 | 0.2674 |
55013 | CCDC109B | C57 | Human | Oral cavity | OSCC | 1.13e-07 | 3.91e-01 | 0.1679 |
55013 | CCDC109B | C06 | Human | Oral cavity | OSCC | 1.15e-14 | 1.41e+00 | 0.2699 |
55013 | CCDC109B | C07 | Human | Oral cavity | OSCC | 2.20e-08 | 1.07e+00 | 0.2491 |
55013 | CCDC109B | C08 | Human | Oral cavity | OSCC | 6.57e-27 | 7.23e-01 | 0.1919 |
55013 | CCDC109B | LN46 | Human | Oral cavity | OSCC | 8.20e-24 | 9.54e-01 | 0.1666 |
55013 | CCDC109B | LP15 | Human | Oral cavity | LP | 4.08e-03 | 6.36e-01 | 0.2174 |
55013 | CCDC109B | LP17 | Human | Oral cavity | LP | 4.56e-07 | 9.65e-01 | 0.2349 |
55013 | CCDC109B | SYSMH1 | Human | Oral cavity | OSCC | 1.77e-06 | 1.72e-01 | 0.1127 |
55013 | CCDC109B | SYSMH2 | Human | Oral cavity | OSCC | 4.07e-14 | 3.59e-01 | 0.2326 |
55013 | CCDC109B | SYSMH3 | Human | Oral cavity | OSCC | 4.92e-24 | 6.22e-01 | 0.2442 |
55013 | CCDC109B | SYSMH4 | Human | Oral cavity | OSCC | 2.47e-02 | 6.67e-02 | 0.1226 |
55013 | CCDC109B | P1_cSCC | Human | Skin | cSCC | 1.07e-39 | 1.36e+00 | 0.0292 |
55013 | CCDC109B | P2_cSCC | Human | Skin | cSCC | 1.20e-21 | 7.72e-01 | -0.024 |
55013 | CCDC109B | P4_cSCC | Human | Skin | cSCC | 2.14e-61 | 1.48e+00 | -0.00290000000000005 |
55013 | CCDC109B | P10_cSCC | Human | Skin | cSCC | 8.59e-52 | 1.46e+00 | 0.1017 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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