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Gene: CAMKMT |
Gene summary for CAMKMT |
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Gene information | Species | Human | Gene symbol | CAMKMT | Gene ID | 79823 |
Gene name | calmodulin-lysine N-methyltransferase | |
Gene Alias | C2orf34 | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q7Z624 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79823 | CAMKMT | P15T-E | Human | Esophagus | ESCC | 2.63e-18 | 2.47e-01 | 0.1149 |
79823 | CAMKMT | P16T-E | Human | Esophagus | ESCC | 6.97e-13 | 1.72e-01 | 0.1153 |
79823 | CAMKMT | P17T-E | Human | Esophagus | ESCC | 1.68e-08 | 2.12e-01 | 0.1278 |
79823 | CAMKMT | P19T-E | Human | Esophagus | ESCC | 1.85e-04 | 2.39e-01 | 0.1662 |
79823 | CAMKMT | P20T-E | Human | Esophagus | ESCC | 1.85e-15 | 2.63e-01 | 0.1124 |
79823 | CAMKMT | P21T-E | Human | Esophagus | ESCC | 1.95e-16 | 1.55e-01 | 0.1617 |
79823 | CAMKMT | P22T-E | Human | Esophagus | ESCC | 3.66e-20 | 2.38e-01 | 0.1236 |
79823 | CAMKMT | P23T-E | Human | Esophagus | ESCC | 9.50e-16 | 2.99e-01 | 0.108 |
79823 | CAMKMT | P24T-E | Human | Esophagus | ESCC | 4.67e-12 | 1.87e-01 | 0.1287 |
79823 | CAMKMT | P26T-E | Human | Esophagus | ESCC | 3.06e-27 | 4.91e-01 | 0.1276 |
79823 | CAMKMT | P27T-E | Human | Esophagus | ESCC | 1.21e-24 | 2.97e-01 | 0.1055 |
79823 | CAMKMT | P28T-E | Human | Esophagus | ESCC | 8.14e-17 | 1.68e-01 | 0.1149 |
79823 | CAMKMT | P30T-E | Human | Esophagus | ESCC | 2.58e-14 | 4.39e-01 | 0.137 |
79823 | CAMKMT | P31T-E | Human | Esophagus | ESCC | 1.28e-13 | 1.56e-01 | 0.1251 |
79823 | CAMKMT | P32T-E | Human | Esophagus | ESCC | 1.32e-14 | 1.70e-01 | 0.1666 |
79823 | CAMKMT | P36T-E | Human | Esophagus | ESCC | 7.19e-15 | 3.27e-01 | 0.1187 |
79823 | CAMKMT | P37T-E | Human | Esophagus | ESCC | 1.80e-08 | 1.73e-01 | 0.1371 |
79823 | CAMKMT | P39T-E | Human | Esophagus | ESCC | 3.15e-09 | 1.44e-01 | 0.0894 |
79823 | CAMKMT | P42T-E | Human | Esophagus | ESCC | 7.60e-07 | 1.58e-01 | 0.1175 |
79823 | CAMKMT | P44T-E | Human | Esophagus | ESCC | 7.13e-03 | 7.37e-02 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00712148 | Cervix | CC | cellular response to abiotic stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:01040048 | Cervix | CC | cellular response to environmental stimulus | 69/2311 | 331/18723 | 7.36e-06 | 1.73e-04 | 69 |
GO:00093149 | Cervix | CC | response to radiation | 86/2311 | 456/18723 | 3.50e-05 | 5.63e-04 | 86 |
GO:00714786 | Cervix | CC | cellular response to radiation | 41/2311 | 186/18723 | 1.41e-04 | 1.71e-03 | 41 |
GO:00180224 | Cervix | CC | peptidyl-lysine methylation | 28/2311 | 131/18723 | 2.43e-03 | 1.71e-02 | 28 |
GO:00064795 | Cervix | CC | protein methylation | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
GO:00082135 | Cervix | CC | protein alkylation | 36/2311 | 181/18723 | 2.46e-03 | 1.71e-02 | 36 |
GO:00094163 | Cervix | CC | response to light stimulus | 54/2311 | 320/18723 | 1.03e-02 | 4.97e-02 | 54 |
GO:00182054 | Cervix | CC | peptidyl-lysine modification | 62/2311 | 376/18723 | 1.04e-02 | 4.97e-02 | 62 |
GO:0006479 | Colorectum | FAP | protein methylation | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0008213 | Colorectum | FAP | protein alkylation | 39/2622 | 181/18723 | 3.60e-03 | 2.58e-02 | 39 |
GO:0071214 | Colorectum | FAP | cellular response to abiotic stimulus | 63/2622 | 331/18723 | 6.38e-03 | 3.99e-02 | 63 |
GO:0104004 | Colorectum | FAP | cellular response to environmental stimulus | 63/2622 | 331/18723 | 6.38e-03 | 3.99e-02 | 63 |
GO:00712149 | Endometrium | AEH | cellular response to abiotic stimulus | 55/2100 | 331/18723 | 1.85e-03 | 1.46e-02 | 55 |
GO:01040049 | Endometrium | AEH | cellular response to environmental stimulus | 55/2100 | 331/18723 | 1.85e-03 | 1.46e-02 | 55 |
GO:000931410 | Endometrium | AEH | response to radiation | 70/2100 | 456/18723 | 3.99e-03 | 2.68e-02 | 70 |
GO:007121414 | Endometrium | EEC | cellular response to abiotic stimulus | 58/2168 | 331/18723 | 8.25e-04 | 7.64e-03 | 58 |
GO:010400414 | Endometrium | EEC | cellular response to environmental stimulus | 58/2168 | 331/18723 | 8.25e-04 | 7.64e-03 | 58 |
GO:000931413 | Endometrium | EEC | response to radiation | 71/2168 | 456/18723 | 5.69e-03 | 3.42e-02 | 71 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa003102 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa003103 | Colorectum | MSS | Lysine degradation | 24/1875 | 63/8465 | 2.94e-03 | 1.39e-02 | 8.50e-03 | 24 |
hsa003104 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa003105 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa003106 | Colorectum | CRC | Lysine degradation | 18/1091 | 63/8465 | 7.21e-04 | 6.34e-03 | 4.30e-03 | 18 |
hsa003107 | Colorectum | CRC | Lysine degradation | 18/1091 | 63/8465 | 7.21e-04 | 6.34e-03 | 4.30e-03 | 18 |
hsa0031010 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa0031013 | Esophagus | ESCC | Lysine degradation | 41/4205 | 63/8465 | 9.63e-03 | 2.27e-02 | 1.16e-02 | 41 |
hsa003109 | Lung | IAC | Lysine degradation | 17/1053 | 63/8465 | 1.35e-03 | 8.63e-03 | 5.73e-03 | 17 |
hsa0031012 | Lung | IAC | Lysine degradation | 17/1053 | 63/8465 | 1.35e-03 | 8.63e-03 | 5.73e-03 | 17 |
hsa0031022 | Lung | AIS | Lysine degradation | 16/961 | 63/8465 | 1.41e-03 | 9.49e-03 | 6.07e-03 | 16 |
hsa0031032 | Lung | AIS | Lysine degradation | 16/961 | 63/8465 | 1.41e-03 | 9.49e-03 | 6.07e-03 | 16 |
hsa0031042 | Lung | MIAC | Lysine degradation | 10/507 | 63/8465 | 3.93e-03 | 3.18e-02 | 2.30e-02 | 10 |
hsa0031052 | Lung | MIAC | Lysine degradation | 10/507 | 63/8465 | 3.93e-03 | 3.18e-02 | 2.30e-02 | 10 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAMKMT | SNV | Missense_Mutation | c.215N>T | p.Ser72Leu | p.S72L | Q7Z624 | protein_coding | deleterious(0.01) | benign(0.335) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CAMKMT | SNV | Missense_Mutation | c.770C>T | p.Ala257Val | p.A257V | Q7Z624 | protein_coding | tolerated(0.13) | probably_damaging(0.999) | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
CAMKMT | SNV | Missense_Mutation | c.509N>T | p.Asp170Val | p.D170V | Q7Z624 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
CAMKMT | SNV | Missense_Mutation | c.215C>T | p.Ser72Leu | p.S72L | Q7Z624 | protein_coding | deleterious(0.01) | benign(0.335) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
CAMKMT | SNV | Missense_Mutation | c.472A>G | p.Thr158Ala | p.T158A | Q7Z624 | protein_coding | deleterious(0) | benign(0.027) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CAMKMT | SNV | Missense_Mutation | c.721N>T | p.Ala241Ser | p.A241S | Q7Z624 | protein_coding | tolerated(0.13) | possibly_damaging(0.67) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
CAMKMT | SNV | Missense_Mutation | c.719N>A | p.Arg240Lys | p.R240K | Q7Z624 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CAMKMT | SNV | Missense_Mutation | rs201075899 | c.787N>T | p.Arg263Cys | p.R263C | Q7Z624 | protein_coding | tolerated(0.21) | possibly_damaging(0.761) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CAMKMT | SNV | Missense_Mutation | rs759924384 | c.173G>A | p.Arg58Gln | p.R58Q | Q7Z624 | protein_coding | tolerated(0.62) | benign(0.013) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CAMKMT | deletion | Frame_Shift_Del | novel | c.300delN | p.Ser100ArgfsTer4 | p.S100Rfs*4 | Q7Z624 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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