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Gene: C4orf48 |
Gene summary for C4ORF48 |
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Gene information | Species | Human | Gene symbol | C4orf48 | Gene ID | 401115 |
Gene name | chromosome 4 open reading frame 48 | |
Gene Alias | CHR4_55 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401115 | C4orf48 | LZE24T | Human | Esophagus | ESCC | 2.47e-16 | 5.61e-01 | 0.0596 |
401115 | C4orf48 | LZE21T | Human | Esophagus | ESCC | 1.33e-04 | 3.41e-01 | 0.0655 |
401115 | C4orf48 | P2T-E | Human | Esophagus | ESCC | 2.43e-11 | 2.74e-01 | 0.1177 |
401115 | C4orf48 | P4T-E | Human | Esophagus | ESCC | 2.28e-03 | 4.30e-01 | 0.1323 |
401115 | C4orf48 | P5T-E | Human | Esophagus | ESCC | 1.22e-18 | 5.36e-01 | 0.1327 |
401115 | C4orf48 | P8T-E | Human | Esophagus | ESCC | 2.77e-56 | 1.44e+00 | 0.0889 |
401115 | C4orf48 | P9T-E | Human | Esophagus | ESCC | 6.02e-31 | 1.01e+00 | 0.1131 |
401115 | C4orf48 | P10T-E | Human | Esophagus | ESCC | 4.79e-21 | 4.88e-01 | 0.116 |
401115 | C4orf48 | P11T-E | Human | Esophagus | ESCC | 2.85e-12 | 8.86e-01 | 0.1426 |
401115 | C4orf48 | P12T-E | Human | Esophagus | ESCC | 1.56e-23 | 5.02e-01 | 0.1122 |
401115 | C4orf48 | P15T-E | Human | Esophagus | ESCC | 7.42e-15 | 4.16e-01 | 0.1149 |
401115 | C4orf48 | P16T-E | Human | Esophagus | ESCC | 2.50e-53 | 1.12e+00 | 0.1153 |
401115 | C4orf48 | P19T-E | Human | Esophagus | ESCC | 3.56e-04 | 5.35e-01 | 0.1662 |
401115 | C4orf48 | P21T-E | Human | Esophagus | ESCC | 9.15e-35 | 8.30e-01 | 0.1617 |
401115 | C4orf48 | P22T-E | Human | Esophagus | ESCC | 1.23e-74 | 1.34e+00 | 0.1236 |
401115 | C4orf48 | P24T-E | Human | Esophagus | ESCC | 1.16e-29 | 7.37e-01 | 0.1287 |
401115 | C4orf48 | P26T-E | Human | Esophagus | ESCC | 4.05e-08 | 2.78e-01 | 0.1276 |
401115 | C4orf48 | P27T-E | Human | Esophagus | ESCC | 3.78e-23 | 5.34e-01 | 0.1055 |
401115 | C4orf48 | P28T-E | Human | Esophagus | ESCC | 2.01e-52 | 9.61e-01 | 0.1149 |
401115 | C4orf48 | P30T-E | Human | Esophagus | ESCC | 3.91e-20 | 1.01e+00 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4orf48 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | Q5BLP8 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
C4orf48 | deletion | Frame_Shift_Del | novel | c.351delN | p.Arg118ValfsTer20 | p.R118Vfs*20 | Q5BLP8 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
C4orf48 | SNV | Missense_Mutation | c.350N>A | p.Arg117His | p.R117H | Q5BLP8 | protein_coding | deleterious(0) | possibly_damaging(0.872) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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