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Gene: C1orf198 |
Gene summary for C1ORF198 |
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Gene information | Species | Human | Gene symbol | C1orf198 | Gene ID | 84886 |
Gene name | chromosome 1 open reading frame 198 | |
Gene Alias | C1orf198 | |
Cytomap | 1q42.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H425 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84886 | C1orf198 | cirrhotic1 | Human | Liver | Cirrhotic | 2.93e-02 | -1.75e-02 | 0.0202 |
84886 | C1orf198 | cirrhotic2 | Human | Liver | Cirrhotic | 1.77e-02 | 5.96e-02 | 0.0201 |
84886 | C1orf198 | HCC2 | Human | Liver | HCC | 3.23e-02 | 2.76e+00 | 0.5341 |
84886 | C1orf198 | Pt13.b | Human | Liver | HCC | 1.62e-08 | 7.50e-02 | 0.0251 |
84886 | C1orf198 | S027 | Human | Liver | HCC | 3.80e-09 | 1.04e+00 | 0.2446 |
84886 | C1orf198 | S028 | Human | Liver | HCC | 3.80e-19 | 9.54e-01 | 0.2503 |
84886 | C1orf198 | S029 | Human | Liver | HCC | 4.14e-19 | 9.42e-01 | 0.2581 |
84886 | C1orf198 | C04 | Human | Oral cavity | OSCC | 1.78e-05 | 3.71e-01 | 0.2633 |
84886 | C1orf198 | C21 | Human | Oral cavity | OSCC | 2.94e-16 | 5.15e-01 | 0.2678 |
84886 | C1orf198 | C30 | Human | Oral cavity | OSCC | 6.48e-08 | 5.31e-01 | 0.3055 |
84886 | C1orf198 | C46 | Human | Oral cavity | OSCC | 1.97e-10 | 1.56e-01 | 0.1673 |
84886 | C1orf198 | C57 | Human | Oral cavity | OSCC | 3.19e-05 | 2.25e-01 | 0.1679 |
84886 | C1orf198 | C08 | Human | Oral cavity | OSCC | 4.50e-13 | 3.44e-01 | 0.1919 |
84886 | C1orf198 | C09 | Human | Oral cavity | OSCC | 2.06e-15 | 5.97e-01 | 0.1431 |
84886 | C1orf198 | LP17 | Human | Oral cavity | LP | 1.19e-02 | 2.61e-01 | 0.2349 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1orf198 | SNV | Missense_Mutation | novel | c.250N>C | p.Asp84His | p.D84H | Q9H425 | protein_coding | tolerated(0.43) | benign(0) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
C1orf198 | SNV | Missense_Mutation | novel | c.792A>C | p.Arg264Ser | p.R264S | Q9H425 | protein_coding | tolerated(0.09) | benign(0.085) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
C1orf198 | SNV | Missense_Mutation | rs749135657 | c.596G>A | p.Arg199Gln | p.R199Q | Q9H425 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
C1orf198 | SNV | Missense_Mutation | rs749135657 | c.596N>A | p.Arg199Gln | p.R199Q | Q9H425 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf198 | SNV | Missense_Mutation | novel | c.742N>A | p.Leu248Ile | p.L248I | Q9H425 | protein_coding | tolerated(0.24) | benign(0.024) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1orf198 | SNV | Missense_Mutation | rs375540477 | c.532N>A | p.Ala178Thr | p.A178T | Q9H425 | protein_coding | tolerated(0.11) | benign(0.246) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C1orf198 | SNV | Missense_Mutation | novel | c.358N>C | p.Ser120Pro | p.S120P | Q9H425 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C1orf198 | SNV | Missense_Mutation | rs370439547 | c.862N>T | p.Pro288Ser | p.P288S | Q9H425 | protein_coding | tolerated(0.77) | benign(0.005) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf198 | SNV | Missense_Mutation | novel | c.901N>A | p.Leu301Met | p.L301M | Q9H425 | protein_coding | tolerated(0.16) | possibly_damaging(0.883) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1orf198 | SNV | Missense_Mutation | novel | c.650N>T | p.Ser217Phe | p.S217F | Q9H425 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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