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Gene: C1RL |
Gene summary for C1RL |
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Gene information | Species | Human | Gene symbol | C1RL | Gene ID | 51279 |
Gene name | complement C1r subcomponent like | |
Gene Alias | C1RL1 | |
Cytomap | 12p13.31 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | Q9NZP8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51279 | C1RL | P130T-E | Human | Esophagus | ESCC | 5.40e-30 | 5.19e-01 | 0.1676 |
51279 | C1RL | NAFLD1 | Human | Liver | NAFLD | 1.95e-07 | 6.48e-01 | -0.04 |
51279 | C1RL | S43 | Human | Liver | Cirrhotic | 1.79e-09 | 8.93e-02 | -0.0187 |
51279 | C1RL | HCC1_Meng | Human | Liver | HCC | 1.93e-26 | -1.69e-01 | 0.0246 |
51279 | C1RL | HCC2_Meng | Human | Liver | HCC | 1.99e-13 | -5.57e-02 | 0.0107 |
51279 | C1RL | HCC1 | Human | Liver | HCC | 3.18e-05 | 2.45e+00 | 0.5336 |
51279 | C1RL | HCC2 | Human | Liver | HCC | 1.46e-05 | 1.58e+00 | 0.5341 |
51279 | C1RL | HCC5 | Human | Liver | HCC | 4.91e-06 | 1.68e+00 | 0.4932 |
51279 | C1RL | Pt13.a | Human | Liver | HCC | 3.59e-07 | -2.32e-01 | 0.021 |
51279 | C1RL | Pt13.c | Human | Liver | HCC | 2.69e-02 | -2.43e-01 | 0.0076 |
51279 | C1RL | Pt14.d | Human | Liver | HCC | 4.16e-03 | -1.68e-01 | 0.0143 |
51279 | C1RL | S027 | Human | Liver | HCC | 5.67e-06 | 8.68e-01 | 0.2446 |
51279 | C1RL | S028 | Human | Liver | HCC | 1.83e-18 | 8.95e-01 | 0.2503 |
51279 | C1RL | S029 | Human | Liver | HCC | 3.63e-14 | 9.71e-01 | 0.2581 |
51279 | C1RL | C04 | Human | Oral cavity | OSCC | 6.80e-06 | 3.11e-01 | 0.2633 |
51279 | C1RL | C21 | Human | Oral cavity | OSCC | 2.05e-10 | 3.84e-01 | 0.2678 |
51279 | C1RL | C30 | Human | Oral cavity | OSCC | 1.21e-17 | 7.29e-01 | 0.3055 |
51279 | C1RL | C38 | Human | Oral cavity | OSCC | 3.70e-03 | 3.84e-01 | 0.172 |
51279 | C1RL | C43 | Human | Oral cavity | OSCC | 8.30e-04 | 7.20e-02 | 0.1704 |
51279 | C1RL | C46 | Human | Oral cavity | OSCC | 6.88e-04 | 1.67e-01 | 0.1673 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:0031638 | Liver | NAFLD | zymogen activation | 16/1882 | 60/18723 | 2.08e-04 | 3.60e-03 | 16 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:00316381 | Liver | Cirrhotic | zymogen activation | 31/4634 | 60/18723 | 6.48e-06 | 1.02e-04 | 31 |
GO:00164853 | Liver | Cirrhotic | protein processing | 85/4634 | 225/18723 | 9.01e-06 | 1.32e-04 | 85 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
GO:00316382 | Liver | HCC | zymogen activation | 38/7958 | 60/18723 | 9.06e-04 | 5.33e-03 | 38 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00164856 | Oral cavity | OSCC | protein processing | 121/7305 | 225/18723 | 4.56e-06 | 5.23e-05 | 121 |
GO:005160432 | Oral cavity | NEOLP | protein maturation | 50/2005 | 294/18723 | 6.46e-04 | 5.47e-03 | 50 |
GO:001648521 | Oral cavity | NEOLP | protein processing | 39/2005 | 225/18723 | 1.68e-03 | 1.17e-02 | 39 |
GO:000225313 | Oral cavity | NEOLP | activation of immune response | 55/2005 | 375/18723 | 9.87e-03 | 4.62e-02 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1RL | SNV | Missense_Mutation | novel | c.1286N>G | p.His429Arg | p.H429R | Q9NZP8 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1RL | SNV | Missense_Mutation | novel | c.681G>T | p.Gln227His | p.Q227H | Q9NZP8 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-D8-A1X5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
C1RL | SNV | Missense_Mutation | c.1090N>A | p.Glu364Lys | p.E364K | Q9NZP8 | protein_coding | tolerated(0.09) | possibly_damaging(0.752) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C1RL | SNV | Missense_Mutation | novel | c.121N>C | p.Ser41Pro | p.S41P | Q9NZP8 | protein_coding | deleterious(0.02) | probably_damaging(0.984) | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
C1RL | SNV | Missense_Mutation | novel | c.836T>G | p.Leu279Arg | p.L279R | Q9NZP8 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-OL-A6VQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1RL | SNV | Missense_Mutation | rs771340998 | c.1277N>T | p.Thr426Met | p.T426M | Q9NZP8 | protein_coding | tolerated(0.44) | benign(0.044) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C1RL | SNV | Missense_Mutation | novel | c.661G>A | p.Asp221Asn | p.D221N | Q9NZP8 | protein_coding | tolerated(0.35) | benign(0.001) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C1RL | SNV | Missense_Mutation | rs758559770 | c.1141N>C | p.Glu381Gln | p.E381Q | Q9NZP8 | protein_coding | tolerated(0.11) | benign(0.117) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
C1RL | SNV | Missense_Mutation | c.739N>T | p.Gly247Cys | p.G247C | Q9NZP8 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-CM-5860-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | SD | |
C1RL | SNV | Missense_Mutation | rs753114917 | c.1319N>G | p.Tyr440Cys | p.Y440C | Q9NZP8 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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