Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: C1QBP

Gene summary for C1QBP

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

C1QBP

Gene ID

708

Gene namecomplement C1q binding protein
Gene AliasCOXPD33
Cytomap17p13.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q07021


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
708C1QBPP17T-EHumanEsophagusESCC2.86e-241.56e+000.1278
708C1QBPP19T-EHumanEsophagusESCC1.55e-182.99e+000.1662
708C1QBPP20T-EHumanEsophagusESCC5.28e-712.02e+000.1124
708C1QBPP21T-EHumanEsophagusESCC1.06e-1053.10e+000.1617
708C1QBPP22T-EHumanEsophagusESCC2.83e-1192.61e+000.1236
708C1QBPP23T-EHumanEsophagusESCC4.31e-722.44e+000.108
708C1QBPP24T-EHumanEsophagusESCC2.11e-832.18e+000.1287
708C1QBPP26T-EHumanEsophagusESCC4.17e-851.94e+000.1276
708C1QBPP27T-EHumanEsophagusESCC1.78e-781.88e+000.1055
708C1QBPP28T-EHumanEsophagusESCC8.54e-1092.66e+000.1149
708C1QBPP30T-EHumanEsophagusESCC2.92e-562.98e+000.137
708C1QBPP31T-EHumanEsophagusESCC2.00e-972.38e+000.1251
708C1QBPP32T-EHumanEsophagusESCC5.23e-1152.98e+000.1666
708C1QBPP36T-EHumanEsophagusESCC3.87e-512.19e+000.1187
708C1QBPP37T-EHumanEsophagusESCC1.34e-662.14e+000.1371
708C1QBPP38T-EHumanEsophagusESCC2.68e-271.91e+000.127
708C1QBPP39T-EHumanEsophagusESCC1.07e-561.58e+000.0894
708C1QBPP40T-EHumanEsophagusESCC1.79e-251.24e+000.109
708C1QBPP42T-EHumanEsophagusESCC6.53e-511.94e+000.1175
708C1QBPP44T-EHumanEsophagusESCC1.82e-361.14e+000.1096
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:001081010CervixCCregulation of cell-substrate adhesion69/2311221/187238.57e-145.69e-1169
GO:00315898CervixCCcell-substrate adhesion96/2311363/187231.48e-138.85e-1196
GO:002260410CervixCCregulation of cell morphogenesis84/2311309/187231.00e-124.29e-1084
GO:00016679CervixCCameboidal-type cell migration110/2311475/187232.66e-116.36e-09110
GO:004578510CervixCCpositive regulation of cell adhesion101/2311437/187231.96e-103.08e-08101
GO:00321035CervixCCpositive regulation of response to external stimulus95/2311427/187235.44e-095.03e-0795
GO:004225510CervixCCribosome assembly25/231161/187231.70e-081.27e-0625
GO:00026837CervixCCnegative regulation of immune system process94/2311434/187232.63e-081.87e-0694
GO:00603267CervixCCcell chemotaxis73/2311310/187232.82e-081.96e-0673
GO:00975298CervixCCmyeloid leukocyte migration56/2311220/187237.21e-084.15e-0656
GO:19000249CervixCCregulation of substrate adhesion-dependent cell spreading23/231157/187238.94e-085.04e-0623
GO:004348410CervixCCregulation of RNA splicing42/2311148/187231.25e-076.24e-0642
GO:00305957CervixCCleukocyte chemotaxis57/2311230/187231.48e-077.07e-0657
GO:00027644CervixCCimmune response-regulating signaling pathway97/2311468/187231.49e-077.07e-0697
GO:00716218CervixCCgranulocyte chemotaxis37/2311125/187232.16e-079.56e-0637
GO:00107699CervixCCregulation of cell morphogenesis involved in differentiation31/231196/187232.43e-071.05e-0531
GO:00509007CervixCCleukocyte migration78/2311369/187231.09e-063.80e-0578
GO:00344469CervixCCsubstrate adhesion-dependent cell spreading32/2311108/187231.36e-064.55e-0532
GO:19033119CervixCCregulation of mRNA metabolic process64/2311288/187231.71e-065.64e-0564
GO:003311910CervixCCnegative regulation of RNA splicing13/231125/187231.83e-065.89e-0513
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
C1QBPSNVMissense_Mutationnovelc.529N>Cp.Asp177Hisp.D177HQ07021protein_codingtolerated(0.13)possibly_damaging(0.807)TCGA-HM-A4S6-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinCR
C1QBPSNVMissense_Mutationc.352N>Ap.Ala118Thrp.A118TQ07021protein_codingdeleterious(0.04)possibly_damaging(0.601)TCGA-QG-A5Z2-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
C1QBPSNVMissense_Mutationnovelc.304N>Ap.Leu102Ilep.L102IQ07021protein_codingtolerated(0.22)possibly_damaging(0.562)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
C1QBPSNVMissense_Mutationnovelc.814N>Ap.Leu272Ilep.L272IQ07021protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A5-A2K5-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
C1QBPSNVMissense_Mutationc.245N>Cp.Phe82Serp.F82SQ07021protein_codingdeleterious(0)possibly_damaging(0.764)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
C1QBPSNVMissense_Mutationrs115819590c.643N>Ap.Gly215Serp.G215SQ07021protein_codingtolerated_low_confidence(0.09)benign(0.107)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
C1QBPSNVMissense_Mutationnovelc.751A>Gp.Thr251Alap.T251AQ07021protein_codingtolerated(0.1)possibly_damaging(0.559)TCGA-D1-A175-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapypaclitaxelSD
C1QBPSNVMissense_Mutationnovelc.677N>Cp.Leu226Prop.L226PQ07021protein_codingdeleterious(0)probably_damaging(0.988)TCGA-E6-A1LX-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
C1QBPSNVMissense_Mutationnovelc.296N>Gp.His99Argp.H99RQ07021protein_codingtolerated(0.38)benign(0.055)TCGA-FI-A2D5-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycarboplatinumPD
C1QBPSNVMissense_Mutationc.481N>Ap.Glu161Lysp.E161KQ07021protein_codingdeleterious(0.02)possibly_damaging(0.684)TCGA-18-5595-01Lunglung squamous cell carcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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