![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C15orf40 |
Gene summary for C15ORF40 |
![]() |
Gene information | Species | Human | Gene symbol | C15orf40 | Gene ID | 123207 |
Gene name | chromosome 15 open reading frame 40 | |
Gene Alias | C15orf40 | |
Cytomap | 15q25.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8WUR7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123207 | C15orf40 | P91T-E | Human | Esophagus | ESCC | 7.97e-20 | 1.56e+00 | 0.1828 |
123207 | C15orf40 | P104T-E | Human | Esophagus | ESCC | 2.33e-04 | 4.83e-01 | 0.0931 |
123207 | C15orf40 | P107T-E | Human | Esophagus | ESCC | 1.05e-53 | 1.20e+00 | 0.171 |
123207 | C15orf40 | P126T-E | Human | Esophagus | ESCC | 1.09e-10 | 8.02e-01 | 0.1125 |
123207 | C15orf40 | P127T-E | Human | Esophagus | ESCC | 1.24e-28 | 4.96e-01 | 0.0826 |
123207 | C15orf40 | P128T-E | Human | Esophagus | ESCC | 4.03e-49 | 1.28e+00 | 0.1241 |
123207 | C15orf40 | P130T-E | Human | Esophagus | ESCC | 1.28e-69 | 1.40e+00 | 0.1676 |
123207 | C15orf40 | S43 | Human | Liver | Cirrhotic | 3.67e-04 | -1.12e-01 | -0.0187 |
123207 | C15orf40 | HCC1_Meng | Human | Liver | HCC | 2.14e-69 | 9.44e-02 | 0.0246 |
123207 | C15orf40 | HCC2_Meng | Human | Liver | HCC | 6.90e-26 | 1.11e-01 | 0.0107 |
123207 | C15orf40 | cirrhotic1 | Human | Liver | Cirrhotic | 8.81e-04 | 9.34e-02 | 0.0202 |
123207 | C15orf40 | cirrhotic3 | Human | Liver | Cirrhotic | 1.77e-02 | 2.24e-02 | 0.0215 |
123207 | C15orf40 | HCC2 | Human | Liver | HCC | 2.76e-13 | 2.69e+00 | 0.5341 |
123207 | C15orf40 | Pt13.b | Human | Liver | HCC | 3.08e-19 | 1.26e-01 | 0.0251 |
123207 | C15orf40 | S014 | Human | Liver | HCC | 6.41e-23 | 9.37e-01 | 0.2254 |
123207 | C15orf40 | S015 | Human | Liver | HCC | 8.15e-21 | 9.83e-01 | 0.2375 |
123207 | C15orf40 | S016 | Human | Liver | HCC | 2.18e-27 | 9.42e-01 | 0.2243 |
123207 | C15orf40 | S027 | Human | Liver | HCC | 1.04e-03 | 5.21e-01 | 0.2446 |
123207 | C15orf40 | S028 | Human | Liver | HCC | 7.63e-25 | 1.01e+00 | 0.2503 |
123207 | C15orf40 | S029 | Human | Liver | HCC | 1.77e-18 | 1.14e+00 | 0.2581 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C15orf40 | SNV | Missense_Mutation | c.345G>C | p.Lys115Asn | p.K115N | Q8WUR7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C15orf40 | SNV | Missense_Mutation | novel | c.126N>A | p.Ser42Arg | p.S42R | Q8WUR7 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
C15orf40 | SNV | Missense_Mutation | c.345N>T | p.Lys115Asn | p.K115N | Q8WUR7 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C15orf40 | deletion | Frame_Shift_Del | novel | c.62delN | p.Ala21ValfsTer32 | p.A21Vfs*32 | Q8WUR7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
C15orf40 | insertion | Frame_Shift_Ins | novel | c.276_277insG | p.Pro93AlafsTer8 | p.P93Afs*8 | Q8WUR7 | protein_coding | TCGA-AX-A062-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C15orf40 | insertion | Nonsense_Mutation | novel | c.275_276insGCTGGGATTAGAGGTATG | p.Ala92_Pro93insLeuGlyLeuGluValTer | p.A92_P93insLGLEV* | Q8WUR7 | protein_coding | TCGA-AX-A062-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
C15orf40 | SNV | Missense_Mutation | c.172N>A | p.Asp58Asn | p.D58N | Q8WUR7 | protein_coding | tolerated(0.06) | benign(0.155) | TCGA-33-6737-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | PD | |
C15orf40 | SNV | Missense_Mutation | novel | c.342N>T | p.Arg114Ser | p.R114S | Q8WUR7 | protein_coding | deleterious(0.04) | possibly_damaging(0.623) | TCGA-85-8350-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C15orf40 | SNV | Missense_Mutation | novel | c.310T>C | p.Cys104Arg | p.C104R | Q8WUR7 | protein_coding | deleterious(0) | possibly_damaging(0.831) | TCGA-ZG-A9LZ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |