![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: C14orf2 |
Gene summary for C14ORF2 |
![]() |
Gene information | Species | Human | Gene symbol | C14orf2 | Gene ID | 9556 |
Gene name | ATP synthase membrane subunit j | |
Gene Alias | 6.8PL | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R6N3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9556 | C14orf2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.73e-12 | 2.59e-01 | 0.3005 |
9556 | C14orf2 | AEH-subject1 | Human | Endometrium | AEH | 9.52e-100 | -1.11e+00 | -0.3059 |
9556 | C14orf2 | AEH-subject2 | Human | Endometrium | AEH | 1.51e-79 | -1.11e+00 | -0.2525 |
9556 | C14orf2 | AEH-subject3 | Human | Endometrium | AEH | 2.61e-98 | -1.11e+00 | -0.2576 |
9556 | C14orf2 | AEH-subject4 | Human | Endometrium | AEH | 5.57e-64 | -1.11e+00 | -0.2657 |
9556 | C14orf2 | AEH-subject5 | Human | Endometrium | AEH | 2.61e-98 | -1.11e+00 | -0.2953 |
9556 | C14orf2 | EEC-subject1 | Human | Endometrium | EEC | 6.81e-97 | -1.11e+00 | -0.2682 |
9556 | C14orf2 | EEC-subject2 | Human | Endometrium | EEC | 3.32e-101 | -1.11e+00 | -0.2607 |
9556 | C14orf2 | EEC-subject3 | Human | Endometrium | EEC | 1.79e-100 | -1.11e+00 | -0.2525 |
9556 | C14orf2 | EEC-subject4 | Human | Endometrium | EEC | 3.32e-101 | -1.11e+00 | -0.2571 |
9556 | C14orf2 | EEC-subject5 | Human | Endometrium | EEC | 9.52e-100 | -1.11e+00 | -0.249 |
9556 | C14orf2 | GSM5276934 | Human | Endometrium | EEC | 1.98e-103 | -1.11e+00 | -0.0913 |
9556 | C14orf2 | GSM5276935 | Human | Endometrium | EEC | 9.52e-100 | -1.11e+00 | -0.123 |
9556 | C14orf2 | GSM5276937 | Human | Endometrium | EEC | 1.71e-75 | -1.11e+00 | -0.0897 |
9556 | C14orf2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.63e-67 | -1.11e+00 | -0.1869 |
9556 | C14orf2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 8.57e-61 | -1.11e+00 | -0.1875 |
9556 | C14orf2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.66e-69 | -1.11e+00 | -0.1883 |
9556 | C14orf2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 5.01e-99 | -1.11e+00 | -0.1934 |
9556 | C14orf2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 6.12e-105 | -1.11e+00 | -0.1917 |
9556 | C14orf2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 6.24e-86 | -1.11e+00 | -0.1916 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf2 | SNV | Missense_Mutation | rs749080256 | c.154N>A | p.Val52Ile | p.V52I | P56378 | protein_coding | tolerated(0.38) | benign(0.107) | TCGA-NH-A6GB-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
C14orf2 | SNV | Missense_Mutation | c.182N>T | p.Arg61Ile | p.R61I | P56378 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf2 | SNV | Missense_Mutation | c.42N>G | p.Phe14Leu | p.F14L | P56378 | protein_coding | tolerated_low_confidence(0.73) | benign(0) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
C14orf2 | SNV | Missense_Mutation | novel | c.136G>T | p.Gly46Trp | p.G46W | P56378 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22S-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C14orf2 | SNV | Missense_Mutation | novel | c.101N>C | p.Tyr34Ser | p.Y34S | P56378 | protein_coding | tolerated(0.08) | possibly_damaging(0.747) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C14orf2 | SNV | Missense_Mutation | novel | c.83N>G | p.Ile28Ser | p.I28S | P56378 | protein_coding | tolerated(0.25) | benign(0.373) | TCGA-55-8205-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |