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Gene: C14orf142 |
Gene summary for C14ORF142 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | C14orf142 | Gene ID | 84520 |
| Gene name | GON7 subunit of KEOPS complex | |
| Gene Alias | C14orf142 | |
| Cytomap | 14q32.12 | |
| Gene Type | protein-coding | GO ID | GO:0000408 | UniProtAcc | Q9BXV9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84520 | C14orf142 | C30 | Human | Oral cavity | OSCC | 3.13e-31 | 1.37e+00 | 0.3055 |
| 84520 | C14orf142 | C38 | Human | Oral cavity | OSCC | 1.03e-08 | 8.05e-01 | 0.172 |
| 84520 | C14orf142 | C43 | Human | Oral cavity | OSCC | 1.98e-12 | 3.25e-01 | 0.1704 |
| 84520 | C14orf142 | C46 | Human | Oral cavity | OSCC | 1.28e-06 | 3.15e-01 | 0.1673 |
| 84520 | C14orf142 | C57 | Human | Oral cavity | OSCC | 2.02e-06 | 3.86e-01 | 0.1679 |
| 84520 | C14orf142 | C06 | Human | Oral cavity | OSCC | 8.49e-03 | 7.88e-01 | 0.2699 |
| 84520 | C14orf142 | C08 | Human | Oral cavity | OSCC | 2.92e-21 | 5.22e-01 | 0.1919 |
| 84520 | C14orf142 | C09 | Human | Oral cavity | OSCC | 2.25e-04 | 1.74e-01 | 0.1431 |
| 84520 | C14orf142 | LN22 | Human | Oral cavity | OSCC | 2.84e-09 | 8.04e-01 | 0.1733 |
| 84520 | C14orf142 | LN46 | Human | Oral cavity | OSCC | 1.89e-03 | 2.28e-01 | 0.1666 |
| 84520 | C14orf142 | SYSMH1 | Human | Oral cavity | OSCC | 4.19e-03 | 1.56e-01 | 0.1127 |
| 84520 | C14orf142 | SYSMH2 | Human | Oral cavity | OSCC | 2.19e-07 | 3.15e-01 | 0.2326 |
| 84520 | C14orf142 | SYSMH3 | Human | Oral cavity | OSCC | 4.93e-16 | 4.90e-01 | 0.2442 |
| 84520 | C14orf142 | SYSMH6 | Human | Oral cavity | OSCC | 4.03e-02 | 2.24e-01 | 0.1275 |
| 84520 | C14orf142 | P1_cSCC | Human | Skin | cSCC | 8.80e-17 | 5.15e-01 | 0.0292 |
| 84520 | C14orf142 | P2_cSCC | Human | Skin | cSCC | 7.51e-09 | 3.07e-01 | -0.024 |
| 84520 | C14orf142 | P4_cSCC | Human | Skin | cSCC | 3.25e-06 | 3.37e-01 | -0.00290000000000005 |
| 84520 | C14orf142 | P10_cSCC | Human | Skin | cSCC | 2.28e-16 | 4.71e-01 | 0.1017 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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