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Gene: BTN2A1 |
Gene summary for BTN2A1 |
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Gene information | Species | Human | Gene symbol | BTN2A1 | Gene ID | 11120 |
Gene name | butyrophilin subfamily 2 member A1 | |
Gene Alias | BK14H9.1 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q7KYR7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11120 | BTN2A1 | P126T-E | Human | Esophagus | ESCC | 7.78e-05 | 3.83e-01 | 0.1125 |
11120 | BTN2A1 | P127T-E | Human | Esophagus | ESCC | 2.77e-10 | 1.99e-01 | 0.0826 |
11120 | BTN2A1 | P128T-E | Human | Esophagus | ESCC | 1.19e-19 | 5.61e-01 | 0.1241 |
11120 | BTN2A1 | P130T-E | Human | Esophagus | ESCC | 4.30e-25 | 4.38e-01 | 0.1676 |
11120 | BTN2A1 | C04 | Human | Oral cavity | OSCC | 7.00e-04 | 3.95e-01 | 0.2633 |
11120 | BTN2A1 | C21 | Human | Oral cavity | OSCC | 4.97e-13 | 5.04e-01 | 0.2678 |
11120 | BTN2A1 | C30 | Human | Oral cavity | OSCC | 4.23e-09 | 4.31e-01 | 0.3055 |
11120 | BTN2A1 | C46 | Human | Oral cavity | OSCC | 6.57e-09 | 2.72e-01 | 0.1673 |
11120 | BTN2A1 | C51 | Human | Oral cavity | OSCC | 1.60e-10 | 5.29e-01 | 0.2674 |
11120 | BTN2A1 | C57 | Human | Oral cavity | OSCC | 9.38e-04 | 1.73e-01 | 0.1679 |
11120 | BTN2A1 | SYSMH2 | Human | Oral cavity | OSCC | 2.97e-05 | 2.61e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00508528 | Esophagus | ESCC | T cell receptor signaling pathway | 73/8552 | 123/18723 | 1.54e-03 | 7.24e-03 | 73 |
GO:00508527 | Oral cavity | OSCC | T cell receptor signaling pathway | 68/7305 | 123/18723 | 1.80e-04 | 1.22e-03 | 68 |
GO:00027646 | Oral cavity | OSCC | immune response-regulating signaling pathway | 212/7305 | 468/18723 | 2.93e-03 | 1.27e-02 | 212 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BTN2A1 | SNV | Missense_Mutation | c.955N>G | p.Arg319Gly | p.R319G | Q7KYR7 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
BTN2A1 | SNV | Missense_Mutation | c.500C>G | p.Ser167Cys | p.S167C | Q7KYR7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
BTN2A1 | SNV | Missense_Mutation | rs201996542 | c.1354G>A | p.Val452Ile | p.V452I | Q7KYR7 | protein_coding | tolerated(0.84) | benign(0.029) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BTN2A1 | insertion | Frame_Shift_Ins | novel | c.168_169insA | p.Asn58LysfsTer3 | p.N58Kfs*3 | Q7KYR7 | protein_coding | TCGA-A2-A0SV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Other, specify in notesBisphosphonate therapy | zometa | PD | ||
BTN2A1 | insertion | Nonsense_Mutation | novel | c.599_600insATAGTAGCATATTTGATATATTGGTTCTGTGTCATTGATGGA | p.Leu200_Phe201insTer | p.L200_F201ins* | Q7KYR7 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BTN2A1 | insertion | In_Frame_Ins | novel | c.1232_1233insACCCTATGGTTTACATCCCAGGATCCTTTATCTTTT | p.Gly411_Glu412insProTyrGlyLeuHisProArgIleLeuTyrLeuLeu | p.G411_E412insPYGLHPRILYLL | Q7KYR7 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
BTN2A1 | SNV | Missense_Mutation | novel | c.1178N>C | p.Glu393Ala | p.E393A | Q7KYR7 | protein_coding | tolerated(0.14) | benign(0.111) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
BTN2A1 | SNV | Missense_Mutation | c.455N>T | p.Ser152Leu | p.S152L | Q7KYR7 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
BTN2A1 | SNV | Missense_Mutation | novel | c.869N>C | p.Arg290Thr | p.R290T | Q7KYR7 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BTN2A1 | SNV | Missense_Mutation | c.149N>T | p.Arg50Leu | p.R50L | Q7KYR7 | protein_coding | tolerated(0.18) | benign(0.28) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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