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Gene: ATP13A3 |
Gene summary for ATP13A3 |
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Gene information | Species | Human | Gene symbol | ATP13A3 | Gene ID | 79572 |
Gene name | ATPase 13A3 | |
Gene Alias | AFURS1 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H7F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79572 | ATP13A3 | P75T-E | Human | Esophagus | ESCC | 3.14e-10 | 6.28e-02 | 0.1125 |
79572 | ATP13A3 | P76T-E | Human | Esophagus | ESCC | 8.89e-17 | 5.96e-02 | 0.1207 |
79572 | ATP13A3 | P79T-E | Human | Esophagus | ESCC | 1.46e-14 | 3.00e-01 | 0.1154 |
79572 | ATP13A3 | P80T-E | Human | Esophagus | ESCC | 3.55e-24 | 8.34e-01 | 0.155 |
79572 | ATP13A3 | P82T-E | Human | Esophagus | ESCC | 5.09e-04 | 2.66e-01 | 0.1072 |
79572 | ATP13A3 | P83T-E | Human | Esophagus | ESCC | 5.43e-26 | 1.15e+00 | 0.1738 |
79572 | ATP13A3 | P91T-E | Human | Esophagus | ESCC | 1.72e-06 | 6.51e-01 | 0.1828 |
79572 | ATP13A3 | P104T-E | Human | Esophagus | ESCC | 1.12e-02 | -1.49e-02 | 0.0931 |
79572 | ATP13A3 | P107T-E | Human | Esophagus | ESCC | 5.38e-11 | 3.71e-01 | 0.171 |
79572 | ATP13A3 | P127T-E | Human | Esophagus | ESCC | 3.49e-12 | 1.21e-01 | 0.0826 |
79572 | ATP13A3 | P128T-E | Human | Esophagus | ESCC | 4.78e-11 | 6.78e-01 | 0.1241 |
79572 | ATP13A3 | P130T-E | Human | Esophagus | ESCC | 6.82e-26 | 5.88e-01 | 0.1676 |
79572 | ATP13A3 | NAFLD1 | Human | Liver | NAFLD | 6.17e-10 | 9.72e-01 | -0.04 |
79572 | ATP13A3 | S41 | Human | Liver | Cirrhotic | 4.52e-08 | 7.47e-01 | -0.0343 |
79572 | ATP13A3 | S42 | Human | Liver | HCC | 2.55e-02 | 2.59e-01 | -0.0103 |
79572 | ATP13A3 | S43 | Human | Liver | Cirrhotic | 7.00e-09 | 2.41e-01 | -0.0187 |
79572 | ATP13A3 | HCC1_Meng | Human | Liver | HCC | 6.79e-80 | 6.38e-02 | 0.0246 |
79572 | ATP13A3 | HCC2_Meng | Human | Liver | HCC | 2.04e-32 | 7.54e-02 | 0.0107 |
79572 | ATP13A3 | HCC1 | Human | Liver | HCC | 2.16e-08 | 4.11e+00 | 0.5336 |
79572 | ATP13A3 | HCC2 | Human | Liver | HCC | 6.92e-28 | 4.42e+00 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00725032 | Oral cavity | EOLP | cellular divalent inorganic cation homeostasis | 75/2218 | 486/18723 | 9.77e-03 | 4.42e-02 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ATP13A3 | SNV | Missense_Mutation | novel | c.2949G>A | p.Met983Ile | p.M983I | Q9H7F0 | protein_coding | deleterious(0.03) | benign(0.04) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.3428N>A | p.Arg1143His | p.R1143H | Q9H7F0 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.3065N>A | p.Ser1022Tyr | p.S1022Y | Q9H7F0 | protein_coding | deleterious(0) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.601C>T | p.Pro201Ser | p.P201S | Q9H7F0 | protein_coding | tolerated(0.07) | benign(0.18) | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
ATP13A3 | SNV | Missense_Mutation | rs773074163 | c.1960G>A | p.Ala654Thr | p.A654T | Q9H7F0 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ATP13A3 | SNV | Missense_Mutation | novel | c.3343T>C | p.Tyr1115His | p.Y1115H | Q9H7F0 | protein_coding | deleterious(0.05) | benign(0.289) | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
ATP13A3 | SNV | Missense_Mutation | rs773710020 | c.3572N>T | p.Ala1191Val | p.A1191V | Q9H7F0 | protein_coding | tolerated(0.13) | possibly_damaging(0.709) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ATP13A3 | SNV | Missense_Mutation | c.1262N>T | p.Ala421Val | p.A421V | Q9H7F0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ATP13A3 | SNV | Missense_Mutation | novel | c.3329C>T | p.Ser1110Phe | p.S1110F | Q9H7F0 | protein_coding | tolerated(0.71) | possibly_damaging(0.498) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
ATP13A3 | SNV | Missense_Mutation | c.2573G>A | p.Arg858His | p.R858H | Q9H7F0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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