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Gene: ASCL2 |
Gene summary for ASCL2 |
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Gene information | Species | Human | Gene symbol | ASCL2 | Gene ID | 430 |
Gene name | achaete-scute family bHLH transcription factor 2 | |
Gene Alias | ASH2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99929 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
430 | ASCL2 | P74T-E | Human | Esophagus | ESCC | 3.08e-40 | 1.03e+00 | 0.1479 |
430 | ASCL2 | P75T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.42e-01 | 0.1125 |
430 | ASCL2 | P76T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.25e-01 | 0.1207 |
430 | ASCL2 | P79T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.46e-01 | 0.1154 |
430 | ASCL2 | P80T-E | Human | Esophagus | ESCC | 1.75e-18 | 6.47e-01 | 0.155 |
430 | ASCL2 | P82T-E | Human | Esophagus | ESCC | 3.31e-04 | 3.93e-01 | 0.1072 |
430 | ASCL2 | P84T-E | Human | Esophagus | ESCC | 2.92e-04 | 2.57e-01 | 0.0933 |
430 | ASCL2 | P89T-E | Human | Esophagus | ESCC | 4.65e-09 | 4.49e-01 | 0.1752 |
430 | ASCL2 | P91T-E | Human | Esophagus | ESCC | 5.49e-16 | 1.47e+00 | 0.1828 |
430 | ASCL2 | P127T-E | Human | Esophagus | ESCC | 2.48e-08 | 1.88e-01 | 0.0826 |
430 | ASCL2 | P128T-E | Human | Esophagus | ESCC | 1.64e-03 | 2.27e-01 | 0.1241 |
430 | ASCL2 | P130T-E | Human | Esophagus | ESCC | 6.62e-20 | 4.23e-01 | 0.1676 |
430 | ASCL2 | S014 | Human | Liver | HCC | 4.80e-93 | 3.65e+00 | 0.2254 |
430 | ASCL2 | S015 | Human | Liver | HCC | 5.80e-87 | 4.11e+00 | 0.2375 |
430 | ASCL2 | S016 | Human | Liver | HCC | 7.77e-115 | 3.94e+00 | 0.2243 |
430 | ASCL2 | C04 | Human | Oral cavity | OSCC | 8.39e-29 | 1.07e+00 | 0.2633 |
430 | ASCL2 | C21 | Human | Oral cavity | OSCC | 5.52e-20 | 6.83e-01 | 0.2678 |
430 | ASCL2 | C30 | Human | Oral cavity | OSCC | 6.62e-38 | 1.81e+00 | 0.3055 |
430 | ASCL2 | C38 | Human | Oral cavity | OSCC | 1.01e-05 | 7.74e-01 | 0.172 |
430 | ASCL2 | C43 | Human | Oral cavity | OSCC | 1.02e-42 | 8.00e-01 | 0.1704 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:0001890 | Colorectum | AD | placenta development | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0001892 | Colorectum | AD | embryonic placenta development | 33/3918 | 82/18723 | 5.30e-05 | 9.01e-04 | 33 |
GO:0070482 | Colorectum | AD | response to oxygen levels | 99/3918 | 347/18723 | 4.29e-04 | 4.82e-03 | 99 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0001666 | Colorectum | AD | response to hypoxia | 86/3918 | 307/18723 | 1.77e-03 | 1.46e-02 | 86 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0036293 | Colorectum | AD | response to decreased oxygen levels | 88/3918 | 322/18723 | 3.42e-03 | 2.49e-02 | 88 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00018901 | Colorectum | SER | placenta development | 43/2897 | 144/18723 | 9.10e-06 | 3.03e-04 | 43 |
GO:00018921 | Colorectum | SER | embryonic placenta development | 28/2897 | 82/18723 | 2.24e-05 | 6.43e-04 | 28 |
GO:00704821 | Colorectum | SER | response to oxygen levels | 79/2897 | 347/18723 | 1.99e-04 | 3.64e-03 | 79 |
GO:00016661 | Colorectum | SER | response to hypoxia | 69/2897 | 307/18723 | 7.07e-04 | 9.39e-03 | 69 |
GO:00362931 | Colorectum | SER | response to decreased oxygen levels | 71/2897 | 322/18723 | 1.04e-03 | 1.22e-02 | 71 |
GO:00017011 | Colorectum | SER | in utero embryonic development | 77/2897 | 367/18723 | 2.77e-03 | 2.48e-02 | 77 |
GO:00614581 | Colorectum | SER | reproductive system development | 87/2897 | 427/18723 | 3.69e-03 | 3.07e-02 | 87 |
GO:00486081 | Colorectum | SER | reproductive structure development | 85/2897 | 424/18723 | 6.33e-03 | 4.56e-02 | 85 |
GO:00018902 | Colorectum | MSS | placenta development | 51/3467 | 144/18723 | 1.10e-06 | 3.77e-05 | 51 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASCL2 | SNV | Missense_Mutation | novel | c.127N>T | p.Ala43Ser | p.A43S | Q99929 | protein_coding | tolerated(0.97) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASCL2 | SNV | Missense_Mutation | novel | c.298N>G | p.Arg100Gly | p.R100G | Q99929 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-2Y-A9GW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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