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Gene: AP1G2 |
Gene summary for AP1G2 |
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Gene information | Species | Human | Gene symbol | AP1G2 | Gene ID | 8906 |
Gene name | adaptor related protein complex 1 subunit gamma 2 | |
Gene Alias | G2AD | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q86U03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8906 | AP1G2 | P91T-E | Human | Esophagus | ESCC | 1.19e-14 | 1.56e+00 | 0.1828 |
8906 | AP1G2 | P104T-E | Human | Esophagus | ESCC | 7.08e-06 | 4.07e-01 | 0.0931 |
8906 | AP1G2 | P107T-E | Human | Esophagus | ESCC | 2.39e-19 | 3.92e-01 | 0.171 |
8906 | AP1G2 | P126T-E | Human | Esophagus | ESCC | 4.82e-07 | 6.27e-01 | 0.1125 |
8906 | AP1G2 | P127T-E | Human | Esophagus | ESCC | 1.22e-16 | 9.05e-02 | 0.0826 |
8906 | AP1G2 | P128T-E | Human | Esophagus | ESCC | 2.21e-20 | 8.23e-01 | 0.1241 |
8906 | AP1G2 | P130T-E | Human | Esophagus | ESCC | 2.85e-37 | 7.29e-01 | 0.1676 |
8906 | AP1G2 | C04 | Human | Oral cavity | OSCC | 4.09e-22 | 8.63e-01 | 0.2633 |
8906 | AP1G2 | C21 | Human | Oral cavity | OSCC | 4.25e-39 | 9.64e-01 | 0.2678 |
8906 | AP1G2 | C30 | Human | Oral cavity | OSCC | 2.69e-37 | 1.56e+00 | 0.3055 |
8906 | AP1G2 | C38 | Human | Oral cavity | OSCC | 6.83e-03 | 3.75e-01 | 0.172 |
8906 | AP1G2 | C43 | Human | Oral cavity | OSCC | 2.55e-09 | 3.02e-01 | 0.1704 |
8906 | AP1G2 | C46 | Human | Oral cavity | OSCC | 3.64e-16 | 4.17e-01 | 0.1673 |
8906 | AP1G2 | C51 | Human | Oral cavity | OSCC | 1.55e-07 | 3.78e-01 | 0.2674 |
8906 | AP1G2 | C57 | Human | Oral cavity | OSCC | 4.95e-02 | 1.33e-01 | 0.1679 |
8906 | AP1G2 | C06 | Human | Oral cavity | OSCC | 1.34e-03 | 7.37e-01 | 0.2699 |
8906 | AP1G2 | C08 | Human | Oral cavity | OSCC | 3.59e-12 | 3.72e-01 | 0.1919 |
8906 | AP1G2 | C09 | Human | Oral cavity | OSCC | 1.90e-11 | 3.32e-01 | 0.1431 |
8906 | AP1G2 | LN22 | Human | Oral cavity | OSCC | 3.07e-10 | 6.49e-01 | 0.1733 |
8906 | AP1G2 | LN46 | Human | Oral cavity | OSCC | 7.16e-15 | 5.37e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819317 | Esophagus | HGIN | Golgi vesicle transport | 83/2587 | 296/18723 | 8.59e-11 | 8.89e-09 | 83 |
GO:000689210 | Esophagus | HGIN | post-Golgi vesicle-mediated transport | 26/2587 | 104/18723 | 1.63e-03 | 1.81e-02 | 26 |
GO:000703416 | Esophagus | HGIN | vacuolar transport | 35/2587 | 157/18723 | 2.52e-03 | 2.51e-02 | 35 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:000689818 | Esophagus | ESCC | receptor-mediated endocytosis | 142/8552 | 244/18723 | 5.22e-05 | 4.05e-04 | 142 |
GO:00068963 | Esophagus | ESCC | Golgi to vacuole transport | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:000703410 | Oral cavity | OSCC | vacuolar transport | 103/7305 | 157/18723 | 1.25e-11 | 4.44e-10 | 103 |
GO:00068929 | Oral cavity | OSCC | post-Golgi vesicle-mediated transport | 71/7305 | 104/18723 | 1.37e-09 | 3.33e-08 | 71 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:00068962 | Oral cavity | OSCC | Golgi to vacuole transport | 14/7305 | 20/18723 | 4.95e-03 | 1.94e-02 | 14 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:000703415 | Oral cavity | LP | vacuolar transport | 74/4623 | 157/18723 | 7.85e-10 | 3.70e-08 | 74 |
GO:000689214 | Oral cavity | LP | post-Golgi vesicle-mediated transport | 44/4623 | 104/18723 | 5.90e-05 | 8.05e-04 | 44 |
GO:000689817 | Oral cavity | LP | receptor-mediated endocytosis | 87/4623 | 244/18723 | 7.83e-05 | 1.02e-03 | 87 |
GO:00068961 | Oral cavity | LP | Golgi to vacuole transport | 12/4623 | 20/18723 | 8.24e-04 | 7.23e-03 | 12 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000703419 | Skin | cSCC | vacuolar transport | 74/4864 | 157/18723 | 8.60e-09 | 2.72e-07 | 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517029 | Esophagus | HGIN | Human immunodeficiency virus 1 infection | 51/1383 | 212/8465 | 2.16e-03 | 1.90e-02 | 1.51e-02 | 51 |
hsa041426 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa05170112 | Esophagus | HGIN | Human immunodeficiency virus 1 infection | 51/1383 | 212/8465 | 2.16e-03 | 1.90e-02 | 1.51e-02 | 51 |
hsa0414213 | Esophagus | HGIN | Lysosome | 33/1383 | 132/8465 | 6.65e-03 | 4.37e-02 | 3.47e-02 | 33 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa05170210 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0517038 | Esophagus | ESCC | Human immunodeficiency virus 1 infection | 147/4205 | 212/8465 | 3.37e-09 | 3.53e-08 | 1.81e-08 | 147 |
hsa0517027 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa05170111 | Oral cavity | OSCC | Human immunodeficiency virus 1 infection | 133/3704 | 212/8465 | 1.42e-08 | 1.40e-07 | 7.12e-08 | 133 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414221 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0517028 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
hsa0414231 | Oral cavity | LP | Lysosome | 67/2418 | 132/8465 | 5.13e-08 | 7.77e-07 | 5.01e-07 | 67 |
hsa0517037 | Oral cavity | LP | Human immunodeficiency virus 1 infection | 92/2418 | 212/8465 | 2.18e-06 | 2.20e-05 | 1.42e-05 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AP1G2 | SNV | Missense_Mutation | c.361G>A | p.Gly121Ser | p.G121S | O75843 | protein_coding | tolerated(0.19) | possibly_damaging(0.889) | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
AP1G2 | SNV | Missense_Mutation | novel | c.1976N>A | p.Cys659Tyr | p.C659Y | O75843 | protein_coding | tolerated(0.13) | benign(0.191) | TCGA-A2-A0ES-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
AP1G2 | SNV | Missense_Mutation | novel | c.381N>C | p.Leu127Phe | p.L127F | O75843 | protein_coding | tolerated(0.12) | probably_damaging(0.962) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
AP1G2 | SNV | Missense_Mutation | rs138395869 | c.610N>A | p.Glu204Lys | p.E204K | O75843 | protein_coding | deleterious(0.05) | benign(0.062) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AP1G2 | SNV | Missense_Mutation | c.495G>A | p.Met165Ile | p.M165I | O75843 | protein_coding | tolerated(1) | benign(0.007) | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
AP1G2 | SNV | Missense_Mutation | c.2348N>T | p.Ser783Leu | p.S783L | O75843 | protein_coding | tolerated(0.35) | benign(0.058) | TCGA-E9-A1R6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
AP1G2 | SNV | Missense_Mutation | c.1163N>A | p.Ala388Asp | p.A388D | O75843 | protein_coding | tolerated(0.2) | benign(0.005) | TCGA-EW-A1PH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
AP1G2 | insertion | Frame_Shift_Ins | rs749982998 | c.1345_1346insG | p.Ala449GlyfsTer49 | p.A449Gfs*49 | O75843 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
AP1G2 | insertion | In_Frame_Ins | novel | c.994_995insGCCCAGCCCTCCCTACCC | p.Ser332delinsCysProAlaLeuProThrPro | p.S332delinsCPALPTP | O75843 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
AP1G2 | deletion | Frame_Shift_Del | novel | c.1241delN | p.Pro414GlnfsTer7 | p.P414Qfs*7 | O75843 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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