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Gene: ANKS1A |
Gene summary for ANKS1A |
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Gene information | Species | Human | Gene symbol | ANKS1A | Gene ID | 23294 |
Gene name | ankyrin repeat and sterile alpha motif domain containing 1A | |
Gene Alias | ANKS1 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q05CP0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23294 | ANKS1A | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.18e-13 | 4.71e-01 | -0.013 |
23294 | ANKS1A | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.02e-10 | 4.24e-01 | -0.0121 |
23294 | ANKS1A | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.44e-03 | 4.62e-01 | -0.0876 |
23294 | ANKS1A | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 4.40e-03 | 4.42e-01 | -0.0822 |
23294 | ANKS1A | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 8.99e-03 | 4.80e-01 | -0.0809 |
23294 | ANKS1A | HTA12-15-2 | Human | Pancreas | PDAC | 1.30e-02 | 3.94e-01 | 0.2315 |
23294 | ANKS1A | HTA12-25-1 | Human | Pancreas | PDAC | 1.98e-05 | 5.85e-01 | 0.313 |
23294 | ANKS1A | HTA12-26-1 | Human | Pancreas | PDAC | 1.30e-07 | 5.71e-01 | 0.3728 |
23294 | ANKS1A | HTA12-29-1 | Human | Pancreas | PDAC | 4.68e-27 | 6.63e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069292 | Cervix | CC | substrate-dependent cell migration | 9/2311 | 23/18723 | 1.05e-03 | 8.76e-03 | 9 |
GO:00480131 | Cervix | CC | ephrin receptor signaling pathway | 14/2311 | 51/18723 | 2.78e-03 | 1.87e-02 | 14 |
GO:0048013 | Colorectum | MSS | ephrin receptor signaling pathway | 17/3467 | 51/18723 | 8.28e-03 | 4.99e-02 | 17 |
GO:0021700 | Colorectum | FAP | developmental maturation | 57/2622 | 280/18723 | 2.08e-03 | 1.72e-02 | 57 |
GO:00217001 | Colorectum | CRC | developmental maturation | 47/2078 | 280/18723 | 2.52e-03 | 2.38e-02 | 47 |
GO:0006929 | Lung | IAC | substrate-dependent cell migration | 8/2061 | 23/18723 | 2.28e-03 | 2.22e-02 | 8 |
GO:00069291 | Lung | AIS | substrate-dependent cell migration | 9/1849 | 23/18723 | 1.98e-04 | 4.07e-03 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKS1A | SNV | Missense_Mutation | rs140739340 | c.2270G>A | p.Arg757His | p.R757H | Q92625 | protein_coding | deleterious(0.03) | possibly_damaging(0.742) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKS1A | SNV | Missense_Mutation | rs769495288 | c.814G>C | p.Asp272His | p.D272H | Q92625 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ANKS1A | SNV | Missense_Mutation | c.2912N>G | p.Ser971Cys | p.S971C | Q92625 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
ANKS1A | SNV | Missense_Mutation | c.470C>T | p.Ala157Val | p.A157V | Q92625 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-D8-A73W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
ANKS1A | insertion | Nonsense_Mutation | novel | c.528_529insTTCCTTCATGGCACACAGGGCATTGCCAGTGTTTAAG | p.Met177PhefsTer12 | p.M177Ffs*12 | Q92625 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ANKS1A | deletion | In_Frame_Del | rs773416236 | c.2119_2124delNNNNNN | p.Ser707_Ile708del | p.S707_I708del | Q92625 | protein_coding | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ANKS1A | deletion | Frame_Shift_Del | novel | c.1050delN | p.Phe351LeufsTer46 | p.F351Lfs*46 | Q92625 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ANKS1A | SNV | Missense_Mutation | c.992N>G | p.Ser331Cys | p.S331C | Q92625 | protein_coding | deleterious(0) | benign(0.319) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
ANKS1A | SNV | Missense_Mutation | c.1901C>T | p.Ser634Leu | p.S634L | Q92625 | protein_coding | tolerated(0.43) | probably_damaging(0.977) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ANKS1A | SNV | Missense_Mutation | c.2209G>A | p.Asp737Asn | p.D737N | Q92625 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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