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Gene: AHCTF1 |
Gene summary for AHCTF1 |
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Gene information | Species | Human | Gene symbol | AHCTF1 | Gene ID | 25909 |
Gene name | AT-hook containing transcription factor 1 | |
Gene Alias | ELYS | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0000910 | UniProtAcc | Q8WYP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25909 | AHCTF1 | P107T-E | Human | Esophagus | ESCC | 5.34e-29 | 7.95e-01 | 0.171 |
25909 | AHCTF1 | P126T-E | Human | Esophagus | ESCC | 1.80e-04 | 5.01e-01 | 0.1125 |
25909 | AHCTF1 | P127T-E | Human | Esophagus | ESCC | 6.59e-18 | 2.45e-01 | 0.0826 |
25909 | AHCTF1 | P128T-E | Human | Esophagus | ESCC | 1.05e-12 | 6.42e-01 | 0.1241 |
25909 | AHCTF1 | P130T-E | Human | Esophagus | ESCC | 1.46e-51 | 1.12e+00 | 0.1676 |
25909 | AHCTF1 | HCC1_Meng | Human | Liver | HCC | 4.27e-59 | 7.90e-02 | 0.0246 |
25909 | AHCTF1 | HCC2_Meng | Human | Liver | HCC | 1.16e-10 | -8.47e-04 | 0.0107 |
25909 | AHCTF1 | HCC1 | Human | Liver | HCC | 3.38e-04 | 3.33e+00 | 0.5336 |
25909 | AHCTF1 | HCC2 | Human | Liver | HCC | 3.81e-14 | 3.90e+00 | 0.5341 |
25909 | AHCTF1 | S014 | Human | Liver | HCC | 4.89e-09 | 6.61e-01 | 0.2254 |
25909 | AHCTF1 | S015 | Human | Liver | HCC | 3.47e-05 | 4.73e-01 | 0.2375 |
25909 | AHCTF1 | S016 | Human | Liver | HCC | 1.49e-08 | 5.62e-01 | 0.2243 |
25909 | AHCTF1 | S027 | Human | Liver | HCC | 4.37e-08 | 8.48e-01 | 0.2446 |
25909 | AHCTF1 | S028 | Human | Liver | HCC | 2.89e-17 | 8.92e-01 | 0.2503 |
25909 | AHCTF1 | S029 | Human | Liver | HCC | 1.62e-12 | 7.91e-01 | 0.2581 |
25909 | AHCTF1 | C04 | Human | Oral cavity | OSCC | 1.43e-08 | 5.10e-01 | 0.2633 |
25909 | AHCTF1 | C21 | Human | Oral cavity | OSCC | 1.61e-12 | 5.44e-01 | 0.2678 |
25909 | AHCTF1 | C30 | Human | Oral cavity | OSCC | 2.59e-04 | 3.95e-01 | 0.3055 |
25909 | AHCTF1 | C08 | Human | Oral cavity | OSCC | 8.48e-03 | 8.50e-02 | 0.1919 |
25909 | AHCTF1 | EOLP-1 | Human | Oral cavity | EOLP | 1.78e-08 | 2.37e-01 | -0.0202 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00513021 | Cervix | CC | regulation of cell division | 39/2311 | 177/18723 | 2.05e-04 | 2.33e-03 | 39 |
GO:00469312 | Cervix | CC | pore complex assembly | 9/2311 | 20/18723 | 3.06e-04 | 3.27e-03 | 9 |
GO:00009107 | Cervix | CC | cytokinesis | 37/2311 | 173/18723 | 5.40e-04 | 5.23e-03 | 37 |
GO:0032465 | Cervix | CC | regulation of cytokinesis | 22/2311 | 92/18723 | 1.55e-03 | 1.20e-02 | 22 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:00069991 | Cervix | CC | nuclear pore organization | 6/2311 | 14/18723 | 4.36e-03 | 2.67e-02 | 6 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:000699713 | Esophagus | ESCC | nucleus organization | 96/8552 | 133/18723 | 4.66e-10 | 1.21e-08 | 96 |
GO:000091016 | Esophagus | ESCC | cytokinesis | 115/8552 | 173/18723 | 2.48e-08 | 4.68e-07 | 115 |
GO:00069994 | Esophagus | ESCC | nuclear pore organization | 14/8552 | 14/18723 | 1.71e-05 | 1.52e-04 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa030134 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
hsa030135 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AHCTF1 | SNV | Missense_Mutation | c.6776N>C | p.Arg2259Thr | p.R2259T | Q8WYP5 | protein_coding | deleterious(0.01) | possibly_damaging(0.637) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
AHCTF1 | SNV | Missense_Mutation | c.1327G>C | p.Glu443Gln | p.E443Q | Q8WYP5 | protein_coding | deleterious(0) | benign(0.253) | TCGA-A2-A0CX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
AHCTF1 | SNV | Missense_Mutation | c.962A>T | p.Lys321Met | p.K321M | Q8WYP5 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
AHCTF1 | SNV | Missense_Mutation | novel | c.6223G>C | p.Glu2075Gln | p.E2075Q | Q8WYP5 | protein_coding | deleterious(0.03) | probably_damaging(0.959) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AHCTF1 | SNV | Missense_Mutation | c.3646C>G | p.Leu1216Val | p.L1216V | Q8WYP5 | protein_coding | tolerated(0.13) | benign(0.272) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AHCTF1 | SNV | Missense_Mutation | novel | c.6104C>T | p.Ala2035Val | p.A2035V | Q8WYP5 | protein_coding | tolerated(0.24) | benign(0.041) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AHCTF1 | SNV | Missense_Mutation | novel | c.455A>T | p.Gln152Leu | p.Q152L | Q8WYP5 | protein_coding | deleterious(0.01) | possibly_damaging(0.84) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
AHCTF1 | SNV | Missense_Mutation | novel | c.476G>A | p.Arg159Gln | p.R159Q | Q8WYP5 | protein_coding | deleterious(0.01) | possibly_damaging(0.766) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AHCTF1 | SNV | Missense_Mutation | c.1190N>C | p.Asn397Thr | p.N397T | Q8WYP5 | protein_coding | deleterious(0.05) | benign(0.047) | TCGA-AR-A1AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | SD | |
AHCTF1 | SNV | Missense_Mutation | c.4000C>G | p.Pro1334Ala | p.P1334A | Q8WYP5 | protein_coding | deleterious(0.01) | possibly_damaging(0.602) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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