![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ADRBK1 |
Gene summary for ADRBK1 |
![]() |
Gene information | Species | Human | Gene symbol | ADRBK1 | Gene ID | 156 |
Gene name | G protein-coupled receptor kinase 2 | |
Gene Alias | ADRBK1 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0002026 | UniProtAcc | A0A0S2Z392 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
156 | ADRBK1 | C38 | Human | Oral cavity | OSCC | 8.96e-03 | 4.48e-01 | 0.172 |
156 | ADRBK1 | C46 | Human | Oral cavity | OSCC | 1.52e-08 | 1.74e-01 | 0.1673 |
156 | ADRBK1 | C51 | Human | Oral cavity | OSCC | 5.16e-36 | 1.53e+00 | 0.2674 |
156 | ADRBK1 | C57 | Human | Oral cavity | OSCC | 4.49e-13 | 3.24e-01 | 0.1679 |
156 | ADRBK1 | C08 | Human | Oral cavity | OSCC | 6.39e-09 | 2.48e-01 | 0.1919 |
156 | ADRBK1 | C09 | Human | Oral cavity | OSCC | 5.95e-04 | 1.10e-01 | 0.1431 |
156 | ADRBK1 | LN22 | Human | Oral cavity | OSCC | 3.59e-04 | 6.48e-01 | 0.1733 |
156 | ADRBK1 | SYSMH1 | Human | Oral cavity | OSCC | 6.64e-17 | 4.54e-01 | 0.1127 |
156 | ADRBK1 | SYSMH2 | Human | Oral cavity | OSCC | 1.86e-20 | 5.42e-01 | 0.2326 |
156 | ADRBK1 | SYSMH3 | Human | Oral cavity | OSCC | 7.91e-27 | 5.97e-01 | 0.2442 |
156 | ADRBK1 | SYSMH5 | Human | Oral cavity | OSCC | 7.12e-16 | 3.55e-01 | 0.0647 |
156 | ADRBK1 | SYSMH6 | Human | Oral cavity | OSCC | 1.52e-04 | 1.57e-01 | 0.1275 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |