Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ACTR6

Gene summary for ACTR6

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ACTR6

Gene ID

64431

Gene nameactin related protein 6
Gene AliasARP6
Cytomap12q23.1
Gene Typeprotein-coding
GO ID

GO:0006325

UniProtAcc

Q9GZN1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
64431ACTR6P127T-EHumanEsophagusESCC4.69e-171.58e-010.0826
64431ACTR6P128T-EHumanEsophagusESCC4.03e-361.16e+000.1241
64431ACTR6P130T-EHumanEsophagusESCC9.65e-478.44e-010.1676
64431ACTR6HCC1_MengHumanLiverHCC3.48e-803.96e-010.0246
64431ACTR6HCC2_MengHumanLiverHCC5.86e-186.06e-020.0107
64431ACTR6HCC2HumanLiverHCC5.82e-173.93e+000.5341
64431ACTR6S014HumanLiverHCC1.76e-095.24e-010.2254
64431ACTR6S015HumanLiverHCC3.40e-054.41e-010.2375
64431ACTR6S016HumanLiverHCC4.39e-145.75e-010.2243
64431ACTR6S028HumanLiverHCC2.01e-043.22e-010.2503
64431ACTR6S029HumanLiverHCC5.11e-033.72e-010.2581
64431ACTR6C04HumanOral cavityOSCC1.48e-096.38e-010.2633
64431ACTR6C21HumanOral cavityOSCC2.58e-278.75e-010.2678
64431ACTR6C30HumanOral cavityOSCC1.48e-127.17e-010.3055
64431ACTR6C38HumanOral cavityOSCC7.72e-035.72e-010.172
64431ACTR6C43HumanOral cavityOSCC5.01e-315.75e-010.1704
64431ACTR6C46HumanOral cavityOSCC2.65e-215.00e-010.1673
64431ACTR6C57HumanOral cavityOSCC2.57e-042.17e-010.1679
64431ACTR6C08HumanOral cavityOSCC1.68e-153.74e-010.1919
64431ACTR6LN22HumanOral cavityOSCC3.22e-078.45e-010.1733
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000632517EsophagusESCCchromatin organization240/8552409/187236.52e-081.14e-06240
GO:0043486EsophagusESCChistone exchange16/855222/187239.46e-033.28e-0216
GO:000632511LiverHCCchromatin organization206/7958409/187237.23e-044.41e-03206
GO:000632510Oral cavityOSCCchromatin organization190/7305409/187231.17e-035.97e-03190
GO:000632519SkincSCCchromatin organization147/4864409/187234.41e-066.52e-05147
GO:000633812SkincSCCchromatin remodeling94/4864255/187237.58e-057.26e-0494
GO:00718241SkincSCCprotein-DNA complex subunit organization87/4864241/187233.09e-042.47e-0387
GO:00434861SkincSCChistone exchange12/486422/187234.04e-032.15e-0212
GO:000632520ThyroidPTCchromatin organization183/5968409/187232.55e-085.70e-07183
GO:00063385ThyroidPTCchromatin remodeling106/5968255/187236.56e-044.13e-03106
GO:0006325110ThyroidATCchromatin organization189/6293409/187236.40e-081.13e-06189
GO:000633813ThyroidATCchromatin remodeling109/6293255/187231.38e-037.15e-03109
GO:00718242ThyroidATCprotein-DNA complex subunit organization103/6293241/187231.84e-039.03e-03103
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ACTR6SNVMissense_Mutationc.610N>Gp.Gln204Glup.Q204EQ9GZN1protein_codingtolerated(0.15)probably_damaging(0.998)TCGA-A2-A0YK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
ACTR6SNVMissense_Mutationrs375164278c.995N>Ap.Arg332Glnp.R332QQ9GZN1protein_codingdeleterious(0)probably_damaging(0.994)TCGA-OL-A66P-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanCR
ACTR6deletionIn_Frame_Delc.21_59delTAATGGAGCTTACAACGCCAAAATCGGTTACAGCCATGAp.Asp7_His19delp.D7_H19delQ9GZN1protein_codingTCGA-BH-A0BZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinCR
ACTR6SNVMissense_Mutationrs747971263c.91N>Tp.Arg31Trpp.R31WQ9GZN1protein_codingdeleterious(0)probably_damaging(0.985)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ACTR6SNVMissense_Mutationc.1136G>Ap.Arg379Lysp.R379KQ9GZN1protein_codingtolerated(0.47)benign(0.063)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ACTR6SNVMissense_Mutationc.122N>Ap.Thr41Asnp.T41NQ9GZN1protein_codingdeleterious(0)possibly_damaging(0.686)TCGA-LP-A4AW-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ACTR6SNVMissense_Mutationnovelc.1162N>Gp.Ser388Glyp.S388GQ9GZN1protein_codingtolerated(0.18)benign(0.038)TCGA-A6-6653-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
ACTR6SNVMissense_Mutationc.704N>Gp.Asp235Glyp.D235GQ9GZN1protein_codingdeleterious(0)probably_damaging(0.961)TCGA-AD-6895-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
ACTR6SNVMissense_Mutationrs745981618c.1013N>Ap.Arg338Glnp.R338QQ9GZN1protein_codingdeleterious(0)probably_damaging(1)TCGA-AD-6899-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownSD
ACTR6SNVMissense_Mutationrs756214514c.514N>Tp.Arg172Trpp.R172WQ9GZN1protein_codingdeleterious(0)probably_damaging(1)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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